Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 170 for “"Integrins"”.
-
Integrins in muscle disease and repair
… to understand the cross talk between these two integrins and to correlate with previous data suggesting a gain of function phenotype by that existence of integrin α5 at the myotendinious junction (MTJ) in α7KO muscle (Nawrotzki et al.,2003) From our data we know that gene therapy with integrin …
-
The roll of integrins in hematopoiesis
… strategies. This work is focused on the role integrins, the major class of cell-extracellular matrix adhesion molecules, play in mediating these signals to hematopoietic cells at two developmental stages. In the erythroid lineage, I show that expansion of committed erythroid progenitors is …
-
Junction Specificity and Transmembrane Linkages of Integrins
We have also isolated a monoclonal antibody, P4B2, which localizes to multiple adhesion junctions, namely, a subset of focal adhesions, the Z-disc of muscle, and neuromuscular junctions. Immunopurification of the antigen to this antibody from chicken brain tissue yielded a complex of three …
-
Beta 3 integrins : negative regulators of angiogenesis
A method was developed to isolate and purify primary murine endothelial cells from lung tissue (MLEC). The cells generated by this method were characterized by immuno-fluorescence detection and FACS analysis and expressed specific antigens including PECAM-1, ICAM-1, ICAM-2, VCAM-1 and VE-cadherin. …
-
Integrins and SPARC : potential implications for cardiac remodeling
Der enorme Umbau des Herzgewebes, wie man ihn nach Drucküberlastung des Ventrikels oder MyokardInfarkt beobachten kann, gilt als eine der kausalen Ursachen des Herzversagens. Die Veränderungen in der Architektur des Herzens beeinflussen die mechanischen Eigenschaften des Herzmuskels, begründet sind …
-
Funktionelle Charakterisierung der Signaltransduktionskaskade des LFA-1-Integrins
… erst nach einer Konformationsänderung des Integrins erfolgen kann. Eine solche Aktivierung des Integrins wird beispielsweise durch Stimulation der T-Lymphozyten über den T-Zell-Antigenrezeptor induziert, wodurch sich jedoch LFA-1-abhängige Signale mit denen des TCRs überlagern. Daher wurde …
-
Correlation between the expression of integrins and their role in cancer progression. Expression pattern of integrins αvβ3, αvβ5 and α5β1 in clinical and experimental tumour samples
The integrins play a crucial role in cancer cell proliferation, migration, differentiation, survival and angiogenesis. It has been shown that integrin expression is positively correlated to cancer dissemination, this suggests targeting selected integrins as an anti-metastatic strategy. The aim of …
-
Regulation of β2-integrins by signalling pathways and cytoplasmic interacting partners
… investigate signalling pathways that regulate β2-integrins (particularly LFA-1, Lymphocyte Function-associated Antigen 1) in B cells and effector T cells. It was now shown that B cells do not require Protein Kinase C βeta or Protein Kinase D for integrin-mediated cell adhesion but inhibition of …
-
Differential expression of beta 2 integrins in Korean Behcet’s disease patients
Background and objectives: Beta 2 integrins (CD11/CD18) are cell adhesion molecules that play a major role in cell migration to inflammatory sites. They also induce cellular signaling, subsequently leading to cytokine production. On our preliminary strudy, we demonstrated possible alteration in …
-
Cell shape & integrins : determinants of extracellular matrix regulation of growth & survival
Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1997.
-
Integrin Modulating Factor 1 (IMF-1): A lipid that modulates leukocyte integrins
… representative β<sub>1</sub> and β<sub>3</sub> integrins. IMF-1 has a molecular weight of 340 ± 16 daltons by size exclusion chromatography and appears to be distinct from the known lipid products of PMN. The data suggest that PMN control their adhesivity through a novel lipid that may act as an …
-
The Roles of the Collagen Binding Integrins in the Regulation of Endothelial Cell Function
… the binding preferences of collagen binding integrins (α1β1, α2β1, α10β1 and α11β1), and to then assess their role in the regulation of endothelial cell (EC) behaviour using human umbilical vein endothelial cells (HUVECs). First, quantitative real-time polymerase chain reaction (qPCR) was …
-
Monocyte adherence to fibronectin: role of CD11/CD18 integrins and relationship to other monocyte functions
… was substantially mediated by CD11/CD18 integrins, via both RGD-dependent and RGD-independent mechanisms. These data indicate that signals arising from foci of pulmonary inflammation are likely determinants of the accumulation of monocytes in the lungs of patients with chronic …
-
Structural and Biochemical Characterization of the αI-domain, the Ligand Binding Domain, of Integrins αDβ2 and αXβ2
β2-integrins are among the most complex cell surface metallo-receptors known, and upon ligand binding, its ligand-binding domain (αI-domain) undergoes allosteric conformational changes. These “shape-shifting” events of the αI-domain are key to the mechanism of integrin action allowing …
-
Integrin-ligand interactions and cytokine production by monocytic cells
… of the integrin family of membrane receptors. Integrins are heterodimeric transmembrane receptors that participate in bidirectional signalling across membranes and have a critical role in cellular adhesion reactions. CD23 interacts with four integrins, αVβ3 and αVβ5 from the αV integrin family, …
-
INTEGRIN ALPHAVBETA3 AS THERAPEUTIC TARGET AND IMAGING BIOMARKER FOR VASCULAR ENDOTHELIAL CELLS AND CANCER EPITHELIAL CELLS
Integrins are heterodimeric transmembrane proteins belonging to a family of cell adhesion receptors evolutionary old and that play pivotal roles in physiological and pathological processes, such as neo-angiogenesis and cancer spreading. Integrins are composed by an extracellular domain, a single …
-
Integrin-targeted cancer immunotherapy
Integrins are a family of heterodimeric cell surface receptors that are functionally important for cell adhesion, migration and proliferation. Certain integrins, especially those that are known to recognize the arginine-glycine-aspartate (RGD) motif, are heavily overexpressed in many cancers …
Page 1 of 9