Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Integrin-linked kinase"”.
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The role of Integrin-Linked Kinase in regulating glucose and lipid homeostasis in adipose tissue
… obesity contributes to insulin resistance. The integrin receptors transmit changes in the extracellular environment to the cell, causing corresponding intracellular adaptations. Integrin-linked-kinase (ILK), an adaptor protein, is a central hub for intracellular signalling of integrins. Previous …
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Cloning, Phenotypic, and Experimental Analysis of Pat-4: The Caenorhabditis Elegans Homologue of Integrin -Linked Kinase
… and early larval development. Interestingly, ""kinase-dead"" and PH domain-disrupted forms of PAT-4/ILK support initial canal outgrowth. However, these canals frequently fail to fully extend during active canal outgrowth resulting in shortened, misshaped mature canals. These results identify a …
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Integrin-Linked Kinase, ECM Composition, and Substrate Rigidity Regulate Focal Adhesion - Actin Coupling, Modulating Survival, Proliferation and Migration: Towards a Biophysical Cancer Biomarker
… numerous physiological and pathogenic processes. Integrins are thought to be the primary receptors that cells use to transduce biochemical and physical signals from the ECM. Integrin - ligand binding is specific for ECM molecules and is regulated by specific protein-protein interactions that …
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In Vivo Investigation of Protein Interactions in Caenorhabditis Elegans by Forster Resonance Energy Transfer Microscopy
… of PAT-4, the C. elegans homologue of integrin-linked kinase (ILK), were investigated by FRET microscopy in living transgenic animals expressing CFP- and YFP-fusion proteins. Quantitative FRET microscopy in living C. elegans was most complicated by large autofluorescence contributions …
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Extracellular matrix protein receptors in Drosophila melanogaster
… of vertebrate proteins that may interact with integrins, a family of cell surface receptors for extracellular matrix ligands. The three integrin-interacting proteins are referred to by their vertebrate names, and include CD81, a member of the tetraspanin family, ILK, integrin-linked kinase, and …
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Μελέτη του σηματοδοτικού μονοπατιού ILK/p-Akt στο ηπατοκυτταρικό καρκίνωμα του ανθρώπου : συσχέτιση με την έκφραση παραγόντων που εμπλέκονται στην απόπτωση και στον κυτταρικό πολλαπλασιασμό
… στην προαναφερθείσα διαδικασία αποτελεί η ILK (Integrin-Linked Kinase), μία κινάση σερίνης-θρεονίνης που παρεμβάλλεται στα σηματοδοτικά μονοπάτια που ξεκινούν από ιντεγκρίνες, αυξητικούς παράγοντες και συμμετέχει στη ρύθμιση κομβικών για το καρκινικό κύτταρο λειτουργιών όπως έλεγχο του …
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Poly (ADP-ribose) polymerase-1 (PARP-1) induces human trophoblast syncytialization
… of cytotrophoblasts is aided by expression of integrin-linked kinase (ILK), a cytoplasmic adapter protein. Nuclear enzyme Poly ADP-ribose Polymerase-1 (PARP-1) and the transcriptional repressor Snail-1 work with ILK to downregulate epithelial cell-cell adhesion. This process would also be …
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Gammabestrahlung führt zur CD95-abhängiger Invasivität in apoptoseresistenten Glioblastomzellen
… Migration läuft über die Aktivierung der PI3Kinase (PI3K), der Integrin-Linked-Kinase (ILK), der Inhibierung von GSK3 und der Expression der Matrix-Metalloproteinasen (MMPs). Caspasen sind an diesem Signalweg nicht beteiligt. Das direkte Verbindungsglied unterhalb des CD95-Rezeptors konnte …
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Determining Mechanisms by which Pathological Extracellular Matrix induces Ocular Hypertensive Phenotypes in Human Trabecular Meshwork Cells
… (3) To determine whether genipin-induced crosslinked CDM (XCDM) stiffens hTM cells via dysregulating β-catenin and Yes-associated protein (YAP)/Transcriptional co-activator with a PDZ-binding motif (TAZ) signaling pathways, hTM cells were seeded on CDMs/XCDMs for 24h. Where applicable, …
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Molecular Mechanism of Zipper Interacting Protein Kinase
… calcium/calmodulin regulated myosin light chain kinase (MLCK) and smooth muscle myosin phosphatase (SMPP-1M) determine the amount of force generated by smooth muscle. The calcium-independent signaling mediated by myosin phosphatase is regulated by several kinases which include zipper interacting …
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Mechanisms of cell adhesion regulation by herpes simplex virus
… pUL7:pUL51. The IPP complex, which consists of integrin-linked kinase (ILK), PINCH and parvin, was identified as a potential interaction partner for pUL7:pUL51 at focal adhesions. Colocalisation and a direct interaction was confirmed using immunofluorescence microscopy and biochemical approaches …
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Molecular mechanisms of strain-stimulated intestinal epithelial cell differentiation and migration
… of strain or that of EGF. Blocking Src and PI-3-kinase prevented strain induction of Schlafen 3, but Schlafen 3 induction required activation of p38 but not ERK. These results suggest that cyclic strain induces an absorptive phenotype characterized by increased DPPIV activity via Src-, p38-, and …
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ROLE OF PINCH IN ABERRANT TAU PHOSPHORYLATION IN HIV CNS DISEASE
… a non-catalytic scaffolding protein that binds integrin-linked kinase (ILK), and PP1α and mediates Akt and GSK3β kinase activities, all of which when disrupted contribute to aberrant Tau phosphorylation. In Tat transgenic mice, increased expression levels of PINCH, PP1α and hpTau were observed. …