Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Integrin signaling"”.
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Integrin-Mediated Mechanotransduction Controls Activation of Yap and Invasive Growth of Breast Cancer
… with the aggressiveness of breast cancer. Integrin-mediated adhesion and signaling are crucial for mammary tumorigenesis and tumor progression, in which focal adhesion kinase (FAK) - Src family kinases (SFKs) serves as a hub to relay the mechanical cues from the ECM. We have investigated …
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Development of a Model System for Culturing Neonatal Rat Ventricular Myocytes in vitro to Monitor Integrin Activation in Response to Altered Contractile Force
… by the contractile apparatus and sensed by integrins is central to understanding the pathogenesis of HCM. Integrins are likely the mechanotransducers in cardiomyocytes, converting mechanical stress into chemical signals that stimulate cardiac hypertrophy. Outside-in integrin signaling has …
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Effects of somatic cell nuclear transfer on transcripts related to IGF signaling, EGF signaling and cell adhesion during the peri-implantation period in cattle
… that insulin-like growth factor (IGF) signaling, epidermal growth factor (EGF) signaling, and cell adhesion are perturbed in bovine SCNT pregnancies during the peri-implantation period. To test this hypothesis, we analyzed transcriptomes of endometrial tissue and extra-embryonic tissue …
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Aminoflavone Inhibits α6-integrin and Growth of Tamoxifen Resistant Breast Cancer
… to resistance and adhesion protein α6-integrin is a putative TIC biomarker. Investigational agent Aminoflavone (AF) demonstrates efficacy against breast cancer cells irrespective of ER status. Interestingly, we found tamoxifen resistant (TamR) cells and tumors exhibited elevated …
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Cartilage mechanobiology and transcriptional effects of combined mechanical compression and IGF-1 stimulation on bovine cartilage explants
… have focused on mechano-regulation of upstream signaling and responses at the level of gene transcription, protein translation and post-translational modifications. Intracellular pathways including those involving integrin signaling, mitogen activated protein kinases (MAPKs), and release of …
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Glycosaminoglycan regulation of cell function
… and the ability of HSGAGs to support FGF signaling was investigated. Cell surface HSGAGs can define the responsiveness of a given cell to FGF1 and FGF2 through multiple receptor isoforms. Stromal cell derived HSGAGs were also identified as critical regulators of tumor cell growth and …
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Roles of PKR in High Grade Serous Ovarian Cancer
… matrix-related pathways, with convergence on integrin signaling, cytoskeletal organization, and matrix remodeling factors across models. Notably, the majority of shared deregulated proteins were adhesion-associated, underscoring a central role for PKR in regulating metastatic mechanics rather …
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BRIDGING TRANSCRIPTION AND SIGNALING TO STUDY C-MYC FUNCTION AND REGULATION IN CANCER CELLS
… growth and matrix signals (received by EGFR and integrins, respectively) and intracellular signaling pathways (MAPK, Rho/ROCK, and PI3K/Akt) that regulate MYC. The modeling results revealed that MYC regulation is primarily driven by EGFR in normal cells, whereas both EGFR and integrin signaling …
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Signaling of integrin lower leg and transmembrane domains
Integrin conformational changes mediate integrin activation and signaling triggered by intracellular molecules or extracellular ligands. Even though it has been shown that TM and/or cytoplasmic α and β domains associate in the resting state and separation of these domains is required for integrin …
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Analysis of gene expression alterations in premalignant progression from normal mammary epithelium to ductal carcinoma in situ by multiple orthogonal tools
… dysregulation of various pathways such as IGF-1 signaling, integrin signaling and fatty acid biosynthesis. To further enrich the expression data and identify low abundance transcripts we employed next generation sequencing (RNA-Seq) using Illumina Genome Analyzer GAIIx. Analysis of the sequencing …
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Structural-based Investigation of FAK and P130Cas in Focal Adhesion
… Src substrate localized in FAs that functions in integrin signaling to promote cell motility, invasion, proliferation and survival. The Src homology 3 (SH3) domain of p130Cas can directly interact with Focal Adhesion Kinase (FAK), which is a non-receptor tyrosine kinase that prominently locates in …
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Modulation of touch sensitivity in Caenorhabditis elegans
… and mosaic analysis to discover two convergent signaling pathways, the integrin/focal adhesion signaling and insulin signaling, that modulate anterior touch sensitivity. Additional genes and pathways are also needed for optimal touch sensitivity in the TRNs, including the RAS/MAPK pathway, …
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Cell-Cell Junction Signaling Regulating DNA Double-Strand Break Repair In Breast Cells
… the cell cycle. Previous data show that ECM signaling regulates HR, as well as the kinetics of ionizing radiation (IR) induced complex formation at break sites, or foci kinetics. Both human breast epithelial cell lines and primary mouse mammary epithelial cells were used to show that the ECM …