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Showing 1 to 6 of 6 for “"Integrator Complex"”.
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Functional Analysis of Drosophila Integrator Complex In Snrna 3' End Processing
… a poorly characterized, twelve-membered protein complex named Integrator Complex.</p> <p>In the effort to understand Integrator Complex function in the formation of the snRNA 3’ end, we performed a functional RNAi screen in <em>Drosophila</em> S2 cells to identify protein factors required for …
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Structure-Function Analysis of Human Integrator Subunit-4
<p><strong>Structure-function analysis of human Integrator subunit 4</strong></p> <p>Anupama Sataluri</p> <p>Advisor: Eric. J. Wagner, Ph.D.</p> <p>Uridine-rich small nuclear RNAs (U snRNA) are RNA Polymerase-II (RNAPII) transcripts that are ubiquitously expressed and are known to be essential for …
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Regulation of INTS-6 by post-translational modifications: exploring phosphorylation, SUMOylation and their biological relevance in Caenorhabditis elegans
The Integrator complex, initially identified by Baillat et al. in 2005, is an evolutionarily conserved protein complex consisting of at least 15 subunits in Homo sapiens, 14 of which have also been described in Caenorhabditis elegans. Although it was initially thought to play a central role in …
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THE ROLE OF INTEGRATOR SUBUNIT 11 IN PROMOTOR-PROXIMAL ATTENUATION OF PROTEIN CODING GENES
The Integrator complex is a 14-subunit protein complex that interacts with RNA polymerase II (RNAPII) in metazoans during transcription of multiple forms of coding and non-coding RNA. Originally described as being responsible for the 3’ cleavage and termination of uridine-rich small nuclear RNA, …
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Structural and Functional Studies of ASCC1 in DNA and RNA Alkylation Damage Response
… in DNA and RNA molecules. Activating signal co-integrator complex 1 (ASCC1) acts with ASCC-ALKBH3 complex in alkylation damage responses. ASCC1 uniquely combines two evolutionarily ancient domains: nucleotide-binding K-Homology (KH) (associated with splicing, transcriptional regulation, and …
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A Cell Biological Determination of Integrator Subunit Localization
… This area was greatly advanced when 12 of the Integrator complex subunits (IntS) were purified in 2005 through their interaction with the C-terminal domain (CTD) of the large subunit (RpbI) of RNAPII. Subsequently, our lab performed a genome-wide RNAi screen that identified two more members of …