Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Integrative Genomics"”.
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Uncovering functional mechanisms in cancer through integrative genomics
The genome has been called the blueprint of life for it encodes a complete set of genetic instructions that specify the precise design and timing of functional molecules (such as RNAs and proteins) responsible for carrying out all cellular processes. In recent years, the human genome, comprised of …
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Integrative Genomics Reveals a Role for GNA13 in Lymphomagenesis
<p>Lymphomas comprise a diverse group of malignancies derived from immune cells. High throughput sequencing has recently emerged as a powerful and versatile method for analysis of the cancer genome and transcriptome. As these data continue to emerge, the crucial work lies in sorting through the …
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Insights into Neuroblastoma Initiation and Disease Progression Through integrative Genomics and Epigenomics
In this dissertation, we use integrative genomics to shed new insights into the molecular lesions and mechanisms that drive neuroblastoma. In Part 1, we use imputation and epigenetic profiling in order to identify the causal germline SNP that drives differential susceptibility to neuroblastoma at …
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INTEGRATIVE GENOMICS UNVEILS TRANSCRIPTION FACTOR ROLES IN CELLULAR FATEAND SPATIALLY RESOLVED TRIPLE-NEGATIVE BREAST CANCER IMMUNITY CAPACITY
In this thesis, we explore integrative genomics through advanced sequencing to understand biological systems and processes, focusing on two main projects. The first investigates transcription factors (TFs) in cellular differentiation, addressing the inefficiency in current cellular conversion …
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Causal inference in integrative genomics: exploring de novo mutations and unravelling causal mechanisms via gene regulatory networks in developmental process
Integrative genomics has revolutionised our understanding of complex biological processes by synergistically combining data from various omics technologies, including genomics, transcriptomics, and epigenomics. In this study, we first focused on integrating genomics and transcriptomics data to …
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Leveraging Systems Immunology To Understand The Molecular Underpinnings Of Chimeric Antigen Receptor T-Cell Therapy
… exciting technological advances in the field of genomics and systems biology, including approaches to capture and analyze RNA expression, protein expression, and chromatin accessibility at a single-cell resolution. In this dissertation, I investigate the molecular basis of CAR T-cell therapy …
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Establishment of the epigenetic landscape in mammalian embryonic stem cells
… a mystery. The goal of this thesis was to use an integrative genomics approach to elucidate the role of cis elements in the establishment of repressive chromatin domains. To this effect, we determined the genetic basis for localization of Polycomb repressive complexes (PRCs) in mammalian embryonic …
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Mixture Model Approaches to Integrative Analysis of Multi-Omics Data and Spatially Correlated Genomic Data
<p>Integrative genomic data analysis is a powerful tool to study the complex biological processes behind a disease. Statistical methods can model the interrelationships of the involved gene activities through jointly analyzing multiple types of genomic data from different platforms (vertical …
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AN IMPROVED GENOMIC SURVEILLANCE APPROACH TO DISSECT THE SARS-COV-2 PANDEMIC
Genomic surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only approach to rapidly monitor and tackle emerging variants of concern (VOC) of the COVID-19 pandemic. Such scrutiny is crucial to limit the spread of VOC that might escape the immune protection conferred …