Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 159 for “"Integrative Biology"”.
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Exploring genomic medicine using integrative biology
… or on any single measurement modality, using integrative biology allows us to think holistically and horizontally. A disease like diabetes can lead to myocardial infarction, nephropathy, and neuropathy; to study diabetes in genomic medicine would require reasoning from a disease to all its …
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Somatic cell nuclear transfer in zebrafish
… State University. Comparative Medicine and Integrative Biology, 2010
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Immune stress and reproduction : insights into the role of norepinephrine and GABA
… Department of Comparative Medicine and Integrative Biology, 2008
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Disease population genetic simulation framework: towards application in modelling disease risk prediction and heritability rate
It has now been over a decade since the first genome-wide association study (GWAS) was conducted. The field has since experienced monumental strides, as evidenced by over half a million associations submitted in the GWAS catalog today, advancements in sequencing technologies, and the development of …
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Investigation of Akirin Nuclear Localization and the Molecular Interaction between Akirin and Taf4 in Drosophila
<p>Akirin is a highly conserved protein that has been linked to myogenesis, cardiomyogenisis, and innate immunity. This investigation focused on Akirin in two different aspects, developmentally and subcellularly. Developmentally, we focused on further characterization of Akirin’s role in embryonic …
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Delivering Signal-Altering Bacterial Effector Proteins to Mammalian Cells Using Cell-Penetrating Peptide Technology
<p>A major role of the mitogen activated protein kinase (MAPK) pathway in eukaryotes is to activate the bacterial pathogen defense response upon the detection of bacterial products in the environment. This defensive signaling results in the induction of inflammation, the transcription of …
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Comparisons of the socio-behavioral differences between chimpanzees (Pan troglodytes) and bonobos (Pan paniscus), investigating the impact of a naturally occurring polymorphic microsatellite deletion in the 5’ flanking region of arginine vasopressin receptor 1a (AVPR1a) on gene expression and sociality within the Pan genus
<p>Among the great apes, chimpanzees are unique in having a polymorphic deletion of a ~350bp microsatellite containing region (DupB) in the 5’ flanking region of the arginine vasopressin receptor 1a (AVPR1a) gene. This results in three genotypes (DupB+/+, DupB+/- and DupB-/-) of AVPR1a in …
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Interaction of akirin and pannier during embryogenesis of Drosophila melanogaster
<p><em>Akirin</em>, a highly conserved protein found in nearly all eukaryote species, is a transcriptional cofactor that has been known to play a critical role in the muscular development in <em>Drosophila</em>. In this study, we identified and analyzed the genetic interaction of <em>akirin …
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Effects of the Cle Elum Reservoir on the Ephemeroptera (Mayflies) of the Cle Elum River
The purpose of this study was to determine the physical and chemical effects of the Cle Elum Reservoir on the Cle Elum River and to evaluate these effects in respect to the Ephemeroptera of the Cle Elum River. Specific objectives were: (1) To determine the effects of the reservoir on current …
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Novel collective prey evasion response of Pseudomonas aeruginosa PAO1 to soil micropredator Myxococcus xanthus DK1622
<p>The search for alternative therapeutics is on the rise because of the threat of multi-drug resistant bacteria. Looking at the hunting strategy of soil-based bacterial micropredators is one avenue of exploration. Myxobacteria are soil predators with a wide prey range including Gram-negative and …
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Investigating biometrics of Perimyotis subflavus in traditional and nontraditional hibernacula in the Southeastern United States as it relates to susceptibility to white-nose syndrome.
<p><em>Perimyotis subflavus, </em>or tricolored bat, populations have declined significantly since the emergence of white-nose syndrome (WNS) and has been proposed for listing as “endangered” under the United States Endangered Species Act. Traditionally, bats use caves as hibernacula, but as …
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The Developmental and Behavioral Effects of Δ9-Tetrahydrocannabinol on a Spastic Mutant
<p>Hyperekplexia is a neurological disorder affecting infants and can be characterized by excessive startle reactions in response to unexpected stimuli. This disease can be modeled in zebrafish in the bandoneon (beo) mutant, where the <em>glrbb</em>mutation results in glycine receptor (GLYR) loss …
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An Integrative Approach to Evaluating Radiocesium Contamination in Fukushima Prefecture
… to become non-exchangeable. This thesis takes an integrative approach to the restoration of radiocesium-contaminated soil in three parts by 1) evaluating the adsorption behavior and mechanisms of Cs<sup>+</sup> in vermiculite, 2) using plants as bioindicators to elucidate long-term radiation …
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The Role of Sirtuin Inhibitors on the Proteomic Responses of the Mussels Mytilus galloprovincialis and Mytilus trossulus to Menadione Induced Oxidative Stress
<p>Global climate change imposes physiological constraints on marine ecosystems that can alter the distribution of intertidal organisms. In one such instance, the native cold-adapted mussel <em>Mytilus trossulus</em> is being replaced along its southern range by the invasive warm-adapted …
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Fire and periodical cicadas: impacts on soil nutrients and understory plant germination
<p><strong>Purpose </strong></p> <p>A compound disturbance, composed of a prescribed fire and a periodical cicada emergence, occurred in northern Georgia in the summer of 2021. Independently these disturbances have substantial effects on the surrounding ecosystems. This study investigated the …
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Sustainably Generating Value-Added Products Using Food-Grade Fungi & Agricultural Waste
<p>Agriculture represents a significant portion of Georgia’s economy. However, this industry produces a significant amount of material byproduct, such as cotton gin trash, and despite research into re-purposing, the uses available are limited and provide little to negative value for producers. Many …
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The contribution of the pectoral fins, body, and the ribbon fin to turning maneuvers of a gymnotiform swimmer
<p>Turning is an ecologically important maneuver in fishes as it is used in prey detection, predator avoidance, and to navigate complex environments. Fishes with traditional control surfaces primarily use body bending and pectoral fins to turn. However, little is known about how fishes with …
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CBD & Ethanol Disrupt Early Embryonic Development
<p>The heavily conserved neural circuits that govern the vertebrate reward system, receive sensory stimuli and produce appropriate, self-preserving responses that correspond to experience-based learning and are driven by the communication of dopamine. Many of these circuits lie within the …
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Transcriptional Regulation of kal-1 in the Nematode Caenorhabditis elegans
<p>X-linked Kallmann syndrome (KS) is a genetic disease that is caused by loss-of-function mutations in the human <em>kal-1</em> gene. The disorder consists of a loss of sense-of-smell coupled with failure to undergo spontaneous puberty. At the cellular level, KS phenotypes are caused by olfactory …
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Nociception and the Experience of Pain Signaling Due to Nerve Damage
<p>Hyperalgesia is the increased sensitivity to pain which can present itself to many people no matter age or ethnicity. Having the ability to alleviate pain whether it be acute or chronic pain without the use of addictive medication can have the potential to change the course or modern medicine …
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