Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Integrase Inhibitors"”.
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Design and synthesis of HIV-1 integrase inhibitors
In recent years, HIV-1 integrase (IN) has emerged as an attractive target for the treatment of human immunodeficiency virus type 1 (HIV-1), the causative pathogen of acquired immuno-deficiency syndrome (AIDS). Several classes of IN inhibitors are known but many of these compounds are toxic, do not …
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Impact of integrase inhibitors on gut and oral microbiome
La infección por el virus de la inmunodeficiencia humana (VIH) es considerada actualmente como una enfermedad crónica gracias al uso del tratamiento antirretroviral (TAR). Sin embargo, a pesar del TAR, estos pacientes pueden presentar un estado de inmunoactivación e inflamación crónica, así como un …
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Synthesis and Computational Studies on Hiv-1 Integrase Inhibitors
HIV-1 integrase (IN) is essential for viral replication and offers a promising target for the development of anti-retroviral drugs. Two decades of extensive research has lead to the recent approval of raltegravir as the first IN inhibitor. Advancement of drug candidate elvitegravir, which is …
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Biochemical Investigation of the Intracellular Trafficking of Non-Viral and Hybrid Gene Therapy Vectors
… to MLV. (Similar experiments attempted with integrase inhibitors did not yield useful results.) Improvement of hybrid vectors probably depends on expediting the escape of VLP from the endolysosomal network and the VLP lipid bilayer. This might be accomplished by developing polymers with …
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Antiretroviral Regimen and Pregnancy Outcomes of Women Living with HIV in a US Cohort
… pregnant and on ART is of paramount importance. Integrase inhibitors (INSTIs) are of particular interest as newer data suggests that these can lead to more rapid viral load reduction. This was a retrospective study of women who are pregnant and living with HIV who received prenatal care at the …
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MODELING AND MODULATING MYELOID CELL-MEDIATED NEUROINFLAMMATION FOLLOWING HUMAN IMMUNODEFICIENCY VIRUS-1 INFECTION
… to HIV-infected myeloid cell supernatants and integrase inhibitors, contrasting reports in primary models. Further investigation determined i3 neurons were resistant to N-methyl-D-aspartate (NMDA) receptor-mediated toxicity. Using microelectrode arrays and RNA-seq, we recorded altered …
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The pharmacologenetics of lopinavir in a cohort of black African HIV/AIDS patients
… and non-nucleoside reverse transcriptase inhibitors (NRTIs/NNRTIs); fusion/entry inhibitors; integrase inhibitors; and protease inhibitors (PIs). In South Africa PIs, specifically lopinavir (LPV) boosted with another PI, ritonavir (RTV) are used in second-line ARV regimens along with a …
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Biochemical, Structural, And Drug Design Studies Of Multi-Drug Resistant Hiv-1 Therapeutic Targets
… to multi-drug resistance to HIV-1 protease and integrase inhibitors. </p> <p>Proper proteolytic processing of the HIV-1 Gag/Pol polyprotein is required for HIV infection and viral replication. This feature has made HIV-1 protease an attractive target for antiretroviral drug design for the …