Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Insulinoma"”.
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Receptor tyrosine kinase target validation and combinatorial strategies to circumvent small molecule therapeutic resistance in canine metastatic insulinoma
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Receptor tyrosine kinase target validation and combinatorial strategies to circumvent small molecule therapeutic resistance in canine metastatic insulinoma
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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iPLA2β, ALTERNATIVE SPLICING AND APOPTOSIS OF PANCREATIC ISLETS
… mouse islets, mouse islet cell lines, and in rat insulinoma (INS1) cells. INS-1 insulinoma cells were treated with thapsigargin to induce ER stress, which can eventually lead to apoptosis. Thapsigarin-treated INS-1 cells exhibited an increase in the ratio of BCL-x(s) (pro-apoptotic) to BCL-x(L) …
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Transglutaminase in the life and death of the pancreatic β-cell
… study using in vitro models of rat pancreatic insulinoma β-cells (BRIN-BD11), and ex vivo islet of Langerhans models from human, rat, TG2(-/-) knockout mice and their wild-type counterparts. The importance of ECM-associated TG2 in the maintenance of β-cell survival and function was also …
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Somatostatin inhibits insulin release via SSTR2 in the hamster pancreatic islets
… [beta]-cells that are derived from hamster insulinoma, it was found that a SSTR2 agonist, but not other SSTR agonists, inhibited insulin release. Since SSTR2 is highly expressed in tumor cells, it is possible that the results from HIT-T15 cells may be due to the nature of tumor cells. Thus, …
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Mitochondrial Involvement in Pancreatic Beta Cell Glucolipotoxicity
… mitochondrial energy metabolism in INS-1E insulinoma cells and isolated pancreatic islets, a role of mitochondria in pancreatic β-cell glucolipotoxicity is uncovered. It is reported that prolonged palmitate exposure at high glucose attenuates glucose-stimulated mitochondrial respiration …
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The genetic background of gestational diabetes mellitus
… against glutamic acid decarboxylase 65 (GAD65), insulinoma-associated antigen 2 (IA-2) and insulin in women who had been diagnosed with GDM at least once during 2000-2004. The HLA-DQB1*0602 allele which is considered to be protective for type 1 diabetes had a negative association with GDM even …
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Nature of Large Vesicle Exocytosis in Pancreatic β-cells: Release of ATP and GABA
… of secretory granules. It was found that in rat insulinoma cells these substances were released independently and with different time course: nucleotides - 280 ms and granular peptide marker IAPP - 2.2 s after the membrane depolarization. In 72% of all exocytotic events nucleotide release was not …
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Neuroendocrine neoplasms of the digestive tract: retrospective classification according to the 2019 WHO grading system, and evaluation of the immunohistochemical marker INSM1
… in 2019 by the World Health Organisation (WHO). Insulinoma-associated protein 1 (INSM1) is a transcription factor that is expressed in neuroendocrine cells, and recent studies have shown that it is a sensitive and specific marker for neuroendocrine differentiation. The aims of this study were to …
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Broad Remodeling of the Acetylproteome by SIRT3 Manipulation Fails to Affect Insulin Secretion or β-cell Metabolism in the Absence of Dietary Overnutrition
… complete SIRT3 knockout in the INS-1 832/13 insulinoma cell line. In the context of this SIRT3 knockout cell line, we re-expressed wild-type SIRT3, β-Galactosidase, or one of three enzymatically inactive mutant forms of SIRT3 to generate lines representing a wide range of SIRT3 expression and …
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Shared Metabolic Pathways in Fuel-Stimulated Insulin Secretion
… (OGC).</p><p>OGC was overexpressed in rat insulinoma 832/13 beta-cells and suppressed in both 832/13 cells and islets, and effects on metabolism and insulin secretion were measured. While overexpression of the OGC failed to alter insulin secretion, its siRNA-mediated suppression resulted in …
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Aspects of autoantibody epitopes in type 1 diabetes
… (IAA), glutamic acid decarboxylase 65 (GADA), insulinoma-associated protein 2 (IA-2A) and the most recently identified zinc T8 transporter (ZnT8A). Together or alone, they are important both to predict T1D and to classify diabetes at the time of clinical onset. The single nucleotide …
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Characterisation and pharmacological regulation of GLP-1-mediated glucose homeostasis
… and OXM-augmented GSIS in the rat INS-1 832/3 insulinoma cell line and ex vivo isolated mouse islets, substantiating the potential of compound 249 to be further developed as a novel T2DM treatment. Overall this thesis presents new evidence on the direct involvement of GLP-1R on GLP-1-regulated …
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Endogenous glucagon-cells are necessary for the glucose-responsiveness of the HIT-T15 hamster β-cell line
… release was investigated using the hamster insulinoma cell line, HIT-T15, as a model of the pancreatic β-cell. Glucose-stimulated insulin release from HIT-T15 cells was concentration-dependent over a range of glucose concentrations between 0 and 15 mM, with immunoreactive-insulin release …
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Insulin-secreting tumors of the islets of Langerhans
Thesis (M.D.)—-Boston University
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Toxicity and biotransformation of 1,1,1,3,3-Pentafluoropropane, 3,3,3-Trifluoropropionic acid and 1,1,1,3-Tetrachloropropane
… effect of 3,3,3-trifluoropropionic acid on rat insulinoma-derived INS-1 cells as possible increase in insulin release. Further investigations are necessary to answer in which step of the metabolic pathway 3,3,3-trifluoropropionic acid interferes or finally which specific enzyme is inhibited or …
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Signalling to intracellular Ca2+ channels
… of RyR in pancreatic β-cells. I used INS-1E insulinoma cells, which have been reported to secrete insulin in response to glucose, to characterise the contribution of RyR to Ca$^{2+}$ entry and release. KCl-evoked Ca$^{2+}$ entry in INS-1E cells was mediated by L-type Ca$^{2+}$ channels. Both …