Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Insulin-stimulated glucose"”.
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The role of PLC, cPKC, L-type calcium channels and CAMKII in insulin stimulated glucose transport in skeletal muscle
There is no abstract available for this dissertation.
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An in vitro study of the effects of free fatty acids on insulin mediated glucose uptake and metabolism by myocytes and fibroblast derived adipocytes
… tissues involved with post-prandial peripheral glucose disposal in response to insulin. Insulin resistance reduces the ability to clear glucose from the circulation resulting in hyperinsulinemia and hyperglycemia with the development of T2D. High levels of plasma free fatty acids (FFAs), …
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Inhibition of Free fatty acid-Induced Insulin Resistance by Rosemary Extract: Investigation of the Mechanisms Involved
… fatty acids (FFA) are highly associated with insulin resistance and are a major risk factor for the development of type 2 diabetes mellitus. This thesis investigates the effect of rosemary extract and rosemary extract polyphenols carnosic acid (CA), rosmarinic acid (RA) and carnosol (COH) on …
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Characterisation of the role of AMP-activated protein kinase in 3T3-L1 adipocytes
… syndrome. In skeletal muscle AMPK stimulates glucose uptake and fatty acid oxidation, whereas in liver it inhibits fatty acid and cholesterol synthesis. The Rab GTPase activating proteins Akt substrate of 160 kDa (AS160) and tre-2/USP6, BUB2, cdc16 domain family member 1 (TBC1C1) have been …
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Effects of Rosemary Extract and Rosemary Extract Polyphenols on Skeletal Muscle Insulin Resistance
Skeletal muscle, a major target tissue of insulin, accounts for ~80% of postprandial glucose disposal and plays a significant role in the regulation of glucose homeostasis. Insulin increases muscle glucose uptake by increasing the translocation of intracellularly stored GLUT4 glucose transporters …
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The Role of Leucine and Its Metabolite (KIC) in Insulin Signalling and Glucose Transport in L6 Myotubes
… have also been implicated in the development of insulin resistance and type 2 diabetes mellitus (T2DM). This study examines the dose-dependent effect of leucine in the presence or absence of other amino acids on glucose transport in L6 rat myotubes. Here we report that leucine significantly …
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Regulation of Akt ignal transduction by glucose metabolism
… compared to most other tissues. I observed an insulin-dependent induction of aerobic glycolysis in adipocytes through lactate production and hypothesised that this phenomenon is critical for adipocytes to enter the anabolic state. I therefore examined the effect of perturbing PFKFB3 activity on …
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Treating type 2 diabetes through insulin resistance
… by hyperglycaemia and the diverse effects of insulin resistance. Obesity, in particular central obesity, is a strong pre-disposing factor for type 2 diabetes. Skeletal muscle is the main site of insulin-stimulated glucose disposal and appears to be the first organ that becomes insulin …
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Genetic and molecular characterisation of metabolic subphenotypes and their contribution to type 2 diabetes aetiology
… including > 55,000 individuals was conducted for insulin resistance after a glucose challenge (post-challenge insulin resistance) to approximate insulin resistance specifically in the post-prandial state, a key but understudied contributor to T2D onset. This revealed ten novel genetic loci for …
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THE EFFECTS OF OBESITY ON PLASMA LEVELS OF OMENTIN, A DEPOT-SPECIFIC ADIPOCYTOKINE
… and secreted in adipose tissue that increases insulin-stimulated glucose transport. To further elucidate omentin's physiological function, its levels were measured by quantitative western blotting in plasma from 44 healthy nondiabetic volunteers (22 women, 22 men). Participants were organized …
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The role of the mitofusins in adipose tissue
… in disorders of energy balance (i.e. weight) or insulin action. Several groups have identified that biallelic p.Arg707Trp mutations in MFN2 (MFN2R707W) cause a striking leptin-deficient partial lipodystrophy syndrome. It is not known why this mutation affects adipose tissue when other mutations …
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The regulation of ceramide content and insulin resistance in skeletal muscle
Insulin resistance is commonly developed in obesity and is a trait of the beginning stage of type 2 diabetes mellitus (DM). It is highly likely that the high plasma fatty acid levels provoke the condition in the obese and insulin resistant state of type 2 DM. Hence, the purpose of this study was to …
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Role of Lipolysis and Lipogenesis in the Development of Diet-Induced Obesity
… Early effects of moderately high fat feeding on insulin-stimulated glucose uptake and metabolism and body composition were examined in another set of experiments. Results demonstrated that <em>in vivo</em> lipolytic responses were not a causative factor in excess body weight and fat accretion in …
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Proteomic profiling of skeletal muscle tissue from the Goto-Kakizaki rat model of type 2 diabetes.
… features of type 2 diabetes (T2D) are both insulin resistance and impaired beta cell function. Abnormal glucose handling and variable degrees of peripheral insulin resistance characterise T2D. Skeletal muscle is the largest insulin-regulated glucose sink in the body and represents …
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ELUCIDATION ON THE MECHANISM OF CAMKKα AS A PRO-GROWTH KINASE IN MOUSE SKELETAL MUSCLE
… been found to be beneficial on two levels. 1) Glucose uptake is increased in exercising skeletal muscle, which is crucial as skeletal muscle accounts for ~85% of insulin-stimulated glucose uptake and the insulin effect is blunted in type 2 diabetes. 2) Post resistance exercise, muscle protein …
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Regulation of Substrate Metabolism and Renin-Angiotensin System with Dietary and Pharmacological Interventions: Implications for Obesity and Related Disorders
… Therefore, we assessed the effects of the KD on glucose, fat, and ketone metabolism in skeletal muscles. We observed that the KD increased fat oxidation and ketolytic capacity, when compared to the HFS group, in a fiber-type specific manner. However, irrespective of oxidative capacity, the KD …
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Angiotensin II receptor blockade and insulin sensitivity in overweight and obese adults with elevated blood pressure
… risk of developing hypertension. Whole-body insulin sensitivity is reduced in obesity, resulting in insulin resistance and increased risk of type 2 diabetes. One possible mechanism contributing to insulin resistance in obesity hypertension is renin-angiotensin system (RAS) overactivation. The …
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Metabolic Bioactivity of Athrixia phylicoides
BACKGROUND: Insulin resistance is a major risk factor for the development of type 2 diabetes (T2D). It is characterized by insufficient response to secreted insulin in target tissues. In vitro studies demonstrated the ability of an aqueous extract of Athrixia phylicoides to increase glucose uptake …
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Dynamic subcellular proteomics identifies novel regulators of adipocyte insulin action
Insulin acts on adipocytes to control whole-body lipid and glucose metabolism. Following binding to its receptor on adipocytes, insulin activates a signalling cascade that promotes glucose uptake and inhibits lipolysis. These processes rely on changes in protein localisation. For example, insulin …
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Exploring the Importance of PREX Proteins in Glucose Homeostasis and Insulin Signalling
… shown to regulate the thermogenic capacity and insulin-stimulated glucose uptake in adipocytes, whereas PREX2 was reported to mediate glucose tolerance, possibly through its adaptor function as an inhibitor of the tumour suppressor PTEN. The aims of this project were to explore the importance of …
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