Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Insulin-producing cells"”.
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Differentiation of mouse embryonic stem cells into insulin-producing cells: optimization to enhance the overall differentiation efficiency
Embryonic stem cells have the potential to differentiate into multiple cell types including insulin-producing cells (IPCs), which is becoming one of the promising cell sources for treating type 1 diabetes mellitus. However, in order to achieve functional stem cell-derived cells, it is important to …
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Pure Insulin Nanoparticle Agglomerates for Pulmonary Delivery
Diabetes is a disease characterized by defects in insulin utilization, either through autoimmune destruction of insulin-producing cells (Type I) or insulin resistance (Type II). Treatment includes regular insulin injections, which can be painful and inconvenient, often leading to low patient …
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Identification And Rescue Of Misregulated Insulin Signaling In A Drosophila Model Of Fragile X Syndrome
… we show that select expression of dfmr1 in the insulin-producing cells (IPCs) of the brain is sufficient to restore normal circadian behavior and to rescue the memory deficits in the fragile X mutant fly. Examination of the insulin signaling pathway revealed elevated levels of Drosophila …
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Human Embryonic Stem Cells - Constitutive Gene Expression and Differentiation Towards Definitive Endoderm and Posterior Foregut Endoderm
… Today´s treatments mainly rely on daily insulin injections. This help people to control blood glucose levels but still many patients suffer from the many complications associated with diabetes. Transplantations of islet cells are an alternative treatment that could help patients to become …
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Phenotypic analysis of human stem cells and their differentiation potential towards pancreatic cells
… the immune system specifically destroys the insulin-producing β-cells of the pancreas, resulting in a loss of glycemic control. There is no cure for the disease, and patients have the difficult task of managing their blood glucose levels by daily injection of insulin, and monitoring of …
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Stem cell-based regenerative pharmacology for the treatment of diabetes mellitus
… is aimed at establishing stem and progenitor cells as effective treatment for preventing disease and facilitating organ replacement or repair. Diabetes mellitus (DM) is a group of chronic metabolic disorders characterized by high blood glucose levels. Type 1 DM (T1DM) is a lack of insulin …
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From Bud to Organ: An In Depth Analysis of the Development of the Pancreas.
… Rgs8 and Rgs16, are expressed in endocrine cells during pancreatic development and become quiescent during adulthood. Only under models of islet regeneration and pancreatic stress was a re-activation of Rgs8 and Rgs16 expression in endocrine cells observed. Our results suggest that Rgs16 and …
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Microencapsulated human islets as a therapy for type 1 diabetes
… Allo- and xeno- transplantation of encapsulated insulin producing cells into immunocompetent rats resulted in a dense pericapsular fibrotic overgrowth. Coating heparin on the microcapsules reduced the fibrotic overgrowth in the allo- but not the xeno- graft model. The absence of dense …
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Stem cell differentiation study: Statistical analysis and application to microarray data
… expression patterns and genetic networks. Stem cells have been of much interest over the past few years. Up to now, scientists have recognized many crucial features that distinguish stem cells from other types of cells: first, stem cells are capable of renewing themselves, serving as the …
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Developing peptide-based inhibitors of amylin aggregation as a novel treatment for type 2 diabetes
… are considered to be cytotoxic to pancreatic -cells. Inhibiting the early stages of amylin aggregation could provide a potential therapeutic strategy for the treatment of type 2 diabetes. In this study, overlapping peptides were designed to target the binding region (RLANFLVHSS, residues 11-20) …
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Understanding The Roles of Non-Homologous End Joining and P53 After Dna Damage
… cellular senescence in developing lymphoid cells, which absolutely suppressed tumorigenesis. Interestingly, these mice progressively succumb to severe diabetes. Mechanistic analysis revealed that spontaneous DNA damage accumulated in the pancreatic b-cells, a unique subset of endocrine cells …
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FGF signaling in specification of hESC-derived definitive endoderm
… the prevention of autoimmune destruction of beta cells and restoration of the beta cell mass restored either through regeneration or transplantation of the insulin producing cells. Islet transplantation according to the Edmonton protocol have been the most promising therapeutic option for Diabetes …