Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Insulin-mimetic"”.
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Metal(ii) schiff base complexes and the insulin-mimetic Studies on the oxovanadium(iv) complexes
… activities comparable or greater than that of insulin. Four unsymmetrical and five symmetrical Schiff base complexes of oxovanadium(IV) have been tested in vivo for their insulin mimetic activities. An acute oral administration of the four unsymmetrical Schiff base complexes of oxovanadium (IV) …
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Antidiabetic activity of Schkuhria pinnata – Biological screening, PK analysis and mode of action
… freeze dried extract and compound 1 enhanced insulin receptor, GLUT-4, glycogen synthase, pyruvate kinase and pyruvate carboxylase expression, suggestive of an insulin mimetic mode of action, while the butanone/pentane extract enhanced adenosine monophosphate-activated kinase (AMPK) protein …
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Investigation of potential intervention targets to improve insulin action: a therapeutic approach
Impaired insulin action (insulin resistance) is a key factor in the pathogenesis of diabetes mellitus. To investigate therapeutic targets against insulin resistance, this thesis explores the mechanism of action of pharmacological agents and exogenous peptides known or suspected to modify insulin …
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Characterization of insulin-stimulated protein kinase cascade in normal and diabetic rats and the effects of vanadium
… (ERK) → S6 kinase → S6 protein phosphorylation. Insulin also activates such a cascade in cultured cells or isolated tissues, but very few studies have investigated the kinase cascade in an intact animal model. In this study, MAP kinase, S6 kinase, p74 [raf1 superscript] and casein kinase-2 (CK-2) …
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Induction of Anopheles stephensi nitric oxide synthase by Plasmodium-derived factor(s)
… AsNOS-inducing factors signal through the insulin signaling pathway and the NF-kappaB-dependent Toll and Immune deficiency (Imd) signaling pathways. In support of this hypothesis, I have determined that signaling by P. falciparum merozoites and PfGPIs is mediated through A. stephensi …
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DIETARY INTERVENTIONS TARGETING GLUCOSE METABOLISM AND HYPERINSULINEMIA: A NEW TRANSLATIONAL PERSPECTIVE FOR THE MANAGEMENT OF ACUTE INTERMITTENT PORPHYRIA
… AIP mice developed glucose intolerance and hyperinsulinemia during fasting. In this model, hepatic glycogen storages were not exploited to normalize glycemia and alternative mechanisms as ketogenesis were aberrantly activated to face with energy demand. In addition, AIP patients with clinically …