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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 39 for “"Insulin-like growth factor-1 (IGF)"”.

  1. Investigating the effects of persistent organic pollutants (POPs) on insulin-like growth factor 1 (IGF-1) in grey seals

    McDonald, ZackAbertay University2025

    … resistance to various forms of degradation. Insulin-like growth factor 1 (IGF-1) is a hormone produced by the liver which is important to numerous processes including metabolism, growth and development, disruption to any of these processes could severely impact survival and reproductive …

    abertay Repository record

  2. Novel recombinant protein constructs for improved insulin-like growth factor-1 delivery

    Was, Adam (Adam S.)Massachusetts Institute of Technology2006

    … were designed to improve the delivery of insulin-like growth factor-1 (IGF-1). The IGF-1 sequence was subcloned into a HisMax plasmid and expressed at low levels by transient transfection in 293 cells. Site-specific mutagenesis was used to insert all four construct sequences into the IGF-1 …

    mit Repository record

  3. THE EFFECTS OF AGE, GH AND IGF-1 ON NEUROMUSCULAR RECOVERY FOLLOWING NERVE TRANSECTION

    Apel, Peter J.Wake Forest University2011

    … there is a decrease in circulating levels of growth hormone (GH) and insulin-like-growth factor 1 (IGF-1). The purpose of this research was to examine the effect of age, GH and IGF-1 on neuromuscular recovery after peripheral nerve injury in aged rats. It was found that with aging, there is a …

    wfu Repository record

  4. Predicting Articular Cartilage Constituent Material Properties Following In Vitro Growth Using a Proteoglycan-Collagen Mixture Model

    Stender, Michael2011

    … for native explants and explants cultured in insulin-like growth factor-1 (IGF-1) and transforming growth factor-β1 (TGF-β1). Results indicate that culture in IGF-1 results in a weakening of the COL fibers compared to native explants, and culture in TGF-β1 results in a strengthening of the COL …

    calpoly Repository record

  5. The impact of multiple acute turkesterone doses on indirect hypertrophy and metabolic measures : a preliminary investigation.

    Harris, Dillon R., 1998-Baylor University.2023

    … To investigate whether turkesterone enhances insulin like growth factor 1 (IGF-1) and resting metabolic rate (RMR), eleven apparently healthy males volunteered to participate in the present study with samples collected pre-, 3H post-, and 24H post-ingestion. The aforementioned dependent …

    baylor Repository record

  6. Local regulation of increased milk yield due to early lactation increased milking frequency

    Hardin, Diana KaitlynVirginia Tech2015

    … difference in gene expression of prolactin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 5 (IGFPB5), or chitinase 3-like-1 (CHI3L1) in mammary tissue at d 21 or 60; and no difference in protein expression of STAT5, Akt, or STAT3 in mammary tissue at d 60.

    vt Repository record

  7. Physical training, inflammation and bone integrity in elite female rowers

    Kurgan, NigelBrock University2017

    … year lead to changes in mineral properties and factors that regulate bone (sclerostin (SOST), osteoprotegerin (OPG)), and receptor activator of nuclear factor kappa-B ligand (RANKL)) and energy metabolism (insulin-like growth factor-1 (IGF-1) and leptin), and inflammation (tumor necrosis …

    brock Repository record

  8. Gain And Loss Of Progranulin Have Opposite Effects On Autophagy

    Berlingieri, StefaniaThe Open University2017

    … cysteine-rich, secreted glycoprotein with growth factor-like properties. PGRN is involved in both metabolism and neurodegeneration. It has recently emerged as an important regulatory adipokine of glucose metabolism and insulin sensitivity. Individuals with obesity and type 2 diabetes were …

    the-open-u Repository record

  9. Skeletal Muscle Protein Turnover During Cancer Cachexia In the Apc<sup>min/+</sup> Mouse

    White, James P

    … stages of cachexia muscle protein synthesis and insulin-like growth factor-1 (IGF-1) signaling were suppressed. Late stage cachexia showed a further reduction in protein synthesis associated with a further reduction in IGF-1 and possible inhibition related to 5`-adenosine monophosphate-activated …

    south-carolina Repository record

  10. Genexpression der GH- IGF-1 Kaskade in endokrin aktiven und endokrin inaktiven Hypophysenadenomen

    Hancke, Katharina

    … (GH) substituiert. Da GH über den Insulin-like-growth-factor-1 (IGF-1) eine mitogene Wirkung auf potentiell vorhandenes, postoperatives Tumorrestgewebe entfalten könnte, stellten wir die Frage, ob neben GH und IGF-1 auch der Growth-Hormon-Receptor (GH-R) und der IGF-1-Receptor …

    freiburg-diss Repository record

  11. Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer

    Coleman, MichaelUniversity College Cork2017

    … of pyrimidine nucleotide carrier 1 (PNC1), an Insulin like Growth Factor 1 (IGF- 1)-inducible mitochondrial Uridine-5'-triphosphate (UTP) transporter in cancer. Loss of PNC1 is lethal, while suppression of PNC1 in cancer cells has been demonstrated to induce Epithelial to Mesenchymal Transition …

    cork Repository record

  12. Cartilage response to in vitro models of injury in combination with growth factor and antioxidant treatments

    Wheeler, Cameron, 1978-Massachusetts Institute of Technology2008

    … the processes involved in the onset of OA and factors leading to OA post-traumatic injury, in vitro models have been developed to isolate components of the complex processes occurring in vivo. While in vitro models do not mimic true physiologic conditions in vivo, by isolating the effects of …

    mit Repository record

  13. The Integrative relationship between insulin and insulin-like growth factor 1 induced cardiovascular responses and sympathetic nervous responses

    Duanmu, Zhengbo2015

    Insulin and insulin-like growth factor 1 (IGF-l) share some structure homologies and exert similar metabolic as well as cardiovascular actions. Insulin and IGF-l have been demonstrated to decrease cardiovascular tone and increase blood flows in skeletal muscle. Insulin has also been showed to …

    wayne-thes Repository record

  14. Regulation of satellite cells by extrinsic factors during recovery from exercise in horses

    Brandt, Amanda MaverickVirginia Tech2019

    … nearby muscle after a damaging event. Hepatocyte growth factor (HGF) and insulin-like growth factor-1 (IGF-1) transcript abundance increased after an exhaustive bout of endurance exercise in concert with myogenic regulator factors and preceding increased SC abundance in a previous study. This …

    vt Repository record

  15. Development of a High-Throughput 3D Tumor Model for Bone Sarcomas

    Santoro, MarcoRice University2016

    … shear stress promoted the secretion of insulin-like growth factor-1 (IGF-1) which, in turn, resulted in shear stress-dependent cell sensitivity to the IGF-1 receptor (IGF-1R) blockade, a central player in ES progression. We then leveraged these findings to culture ES cells on 3D-printed …

    rice Repository record

  16. IGF-1 signalling controls mitochondrial morphology and basal mitophagy in cancer

    Murray, JossUniversity College Cork2023

    Insulin-Like Growth Factor 1 (IGF-1) signalling is known to support oncogenic transformation and the promotion of cancer development. A growing body of evidence has outlined the protective effect IGF-1 signalling has on the mitochondria, however this has been relatively underexplored in cancer. …

    cork Repository record

  17. Spatial and Temporal Variation in Growth Rate of Blue Rockfish (Sebastes mystinus) in Nearshore Central California Determined Using a Physiological Biomarker

    Brauer, Ellie M2022

    … for protecting habitats essential to fish growth and reproduction and, ultimately, for achieving sustainable fisheries. Historically, evaluations of habitat quality have relied heavily on linking spatial variation in fish abundance to environmental parameters such as substrate category, …

    calpoly Repository record

  18. In vitro model of injury/cytokine-induced cartilage catabolism modulated by dynamic compression, growth factors, and glucocorticoids

    Li, Yang, Ph. D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2013

    … initiate cartilage degradation. However, risks factors include traumatic joint injury that results in immediate upregulation of inflammatory cytokines within the joint, as well as direct mechanical damage to the cartilage, factors known to contribute to the onset of OA and its progression. The …

    mit Repository record

  19. Hormonal factors and insulin-like growth factor-1 in North American postmenopausal women

    Chan, Carmen2016

    … exposure on breast cancer risk remain unclear. Insulin-like growth factor-1 (IGF-1) levels have been positively associated with breast cancer and are a potential mechanism. Objectives: The objectives of this thesis are: 1) to explore whether the reproductive risk factors and the lifetime …

    queens Repository record

  20. Biodegradable Hydrogel Composites for Growth Factor and Stem Cell Delivery in Osteochondral Tissue Engineering

    Lu, StevenRice University2016

    … thesis seeks to develop hydrogel composites as growth factor and cell delivery vehicles to study the regeneration of osteochondral tissue. First, we investigated the release of growth factors from acellular hydrogel composites containing gelatin microparticles (GMPs) to stimulate the repair of …

    rice Repository record

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