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Showing 1 to 20 of 86 for “"Insulin-like growth factor-1"”.
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Novel recombinant protein constructs for improved insulin-like growth factor-1 delivery
… were designed to improve the delivery of insulin-like growth factor-1 (IGF-1). The IGF-1 sequence was subcloned into a HisMax plasmid and expressed at low levels by transient transfection in 293 cells. Site-specific mutagenesis was used to insert all four construct sequences into the IGF-1 …
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Hormonal factors and insulin-like growth factor-1 in North American postmenopausal women
… exposure on breast cancer risk remain unclear. Insulin-like growth factor-1 (IGF-1) levels have been positively associated with breast cancer and are a potential mechanism. Objectives: The objectives of this thesis are: 1) to explore whether the reproductive risk factors and the lifetime …
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The differential Role of Insulin-like Growth Factor-1 Isoforms in Skeletal muscle
Insulin-like growth factor-1 (IGF-1) has pleiotropic effects on various tissues during pre- and postnatal development by stimulating proliferation and differentiation, and plays a major role in hypertrophy and tissue remodeling in the fetal, perinatal, and adult organism. In skeletal muscle the …
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Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer
The evolutionarily conserved Insulin-Like Growth Factor 1 (IGF-1) signalling pathway is essential for growth and development and may facilitate cancer progression. While IGF-1 mediates mitochondria protection in some pathologies, whether it is essential for mitochondrial homeostasis in tumour cells …
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Insulin-like growth factor-1 stimulates glycogen synthesis in the bovine uterine epithelium
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo terms
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Charakterisierung der Insulinrezeptor- / Insulin-Like-Growth-Factor 1-Rezeptor-Expression beim duktalen Adenokarzinom des Pankreas
… werden, dass das Ausmaß der Expression des Insulinrezeptors (IR) und des Insulin-like Growth Factor-1 Rezeptors (IGF1R) mit klinisch-pathologischen Patientencharakteristika und dem Überleben korreliert und damit möglichweise eine tumorbiologische Relevanz hat. Beim duktalen Adenokarzinom des …
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Die prognostische Relevanz der Insulinrezeptor- und Insulin-like growth factor-1-Rezeptorexpression beim kolorektalen Karzinom
… es, die vaskuläre und epitheliale Expression des Insulinrezeptors (IR) sowie des Insulin-like growth factor 1 Rezeptors (IGF-1R) im kolorektalen Karzinom zu untersuchen und deren Zusammenhang mit klinisch-pathologischen Parametern und dem Überleben zu analysieren. Zusätzlich wurde die Isoform A …
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The Integrative relationship between insulin and insulin-like growth factor 1 induced cardiovascular responses and sympathetic nervous responses
Insulin and insulin-like growth factor 1 (IGF-l) share some structure homologies and exert similar metabolic as well as cardiovascular actions. Insulin and IGF-l have been demonstrated to decrease cardiovascular tone and increase blood flows in skeletal muscle. Insulin has also been showed to …
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Regulation of the Insulin-like Growth Factor 1-Secretory Clusterin Expression Axis in Genomic Instability and Cell Stress
Secretory clusterin (sCLU) is a pro-survival factor that is up-regulated in human tumors and after exposure to cell stress. Understanding the regulation of sCLU expression in cancer, and after exposure to therapeutic agents, could reveal new therapeutic targets for cancer treatment. A DNA damage …
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Insulin-Like Growth Factor-1 Regulation and Subunit Composition of Low-Voltage Activated Calcium Channels in Atrial Myocytes
To test whether the LVA Ca$\sp{2+}$ channel contains $\beta$ subunit, I studied the ability of an AS ON $(\rm\beta\sb{all})$ targeting a common sequence of all four $\beta$ subunits to modulate the LVA Ca$\sp{2+}$ current in atrial myocytes. Our data showed that LVA Ca$\sp{2+}$ channels were …
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Investigating the effects of persistent organic pollutants (POPs) on insulin-like growth factor 1 (IGF-1) in grey seals
… resistance to various forms of degradation. Insulin-like growth factor 1 (IGF-1) is a hormone produced by the liver which is important to numerous processes including metabolism, growth and development, disruption to any of these processes could severely impact survival and reproductive …
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The neural cell adhesion molecule 2 (NCAM2) promotes excitatory synapse formation through increasing insulin and insulin-like growth factor 1 receptor signaling
… and impaired signaling mediated by the insulin receptor and insulin-like growth factor 1 (IGF1) receptors underlies the pathogenesis of intellectual disability. NCAM2 is enriched at excitatory synapses and is involved in synapse maturation and maintenance. The role of NCAM2 in the …
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Transcriptional Regulation of human Plasminogen Activator Inhibitor-1 Gene Expression by Insulin-like Growth Factor-1, Insulin and Upstream Stimulatory Factor-2
… Thrombose und Hypoxie assoziiert sind. Da Insulin-resistente Stadien durch eine Erhöhung des PAI-1 Spiegels charakterisiert sind haben wir die Mechanismen untersucht, welche die IGF-1- und Insulin-abhängige PAI-1- Induktion in HepG2-Zellen vermitteln. Behandlung der HepG2-Zellen mit IGF-1 …
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Post-Transfer Outcomes in Cultured Bovine Embryos Supplemented with Epidermal Growth Factor, Fibroblast Growth Factor 2, and Insulin-Like Growth Factor 1
… gain for production traits. An uterine paracrine factor cocktail containing epidermal growth factor (EGF), fibroblast growth factor 2 (FGF2), and insulin-like growth factor 1 (IGF1) (collectively termed EFI) was recently identified as a means for improving in vitro derived bovine embryo …
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The Insulin-Like Growth Factor-1 (IGF1) System as a Potential Biomarker for Nutritional Status and Growth Rate in Pacific Rockfish (SEBASTES SPP.)
<p>Growth performance in vertebrates is regulated by environmental factors including the quality and quantity of food, which influences growth via endocrine pathways such as the growth hormone (GH) / insulin-like growth factor somatotropic axis. In several teleost fishes, circulating concentrations …
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THE METABOLIC EFFECTS OF DIET-INDUCED OBESITY AND GROWTH HORMONE TREATMENT IN LONG-LIVED MICE WITH ALTERED INSULIN AND INSULIN-LIKE GROWTH FACTOR -1 SIGNALING
… METABOLIC EFFECTS OF DIET-INDUCED OBESITY AND GROWTH HORMONE TREATMENT IN LONG-LIVED MICE WITH ALTERED INSULIN AND INSULIN-LIKE GROWTH FACTOR -1 SIGNALING MAJOR PROFESSOR: Dr. Andrzej Bartke It is well established that high calorie diets providing mostly fat and simple carbohydrates as …
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Association between insulin like growth factor-1 and muscle mass, muscle strength and physical performance based on European Working Group on Sarcopenia in Older People guideline
BACKGROUND: Aging is associated with various changes in body composition, such as a decrease in muscle mass, bone mineral density, and an increase in body fat. We assumed that these changes were accompanied by decrease of IGF-1 level. We aimed to define relationship between IGF-1 level and muscle …
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Jėgos treniruočių įtaka griaučių raumenų ir kraujo uždegiminių rodiklių pokyčiams: sisteminė literatūros apžvalga /
… on increases in brain-derived neurotrophic factor, fibroblast growth factor-21, and insulin-like growth factor-1 levels were found. There was a statistically significant effect of the number of sets on the decrease in interleukin-6 levels. Strength training was found to significantly …
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Dietary protein and bone health: Harmonizing conflicting theories
… calcium absorption, increasing total circulating insulin-like growth factor 1 or by improving lean body mass which in turn increases bone growth. Although the notion of competing positive and negative pathways has been articulated theoretically, statistical mediation models of this “dual pathways” …
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THE EFFECTS OF AGE, GH AND IGF-1 ON NEUROMUSCULAR RECOVERY FOLLOWING NERVE TRANSECTION
… there is a decrease in circulating levels of growth hormone (GH) and insulin-like-growth factor 1 (IGF-1). The purpose of this research was to examine the effect of age, GH and IGF-1 on neuromuscular recovery after peripheral nerve injury in aged rats. It was found that with aging, there is a …
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