Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Insulin-like growth factor I receptor (IGF-IR)"”.
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Effect of the Insulin-like Growth Factor (IGF) Axis on the Transport Properties of Endothelial and Epithelial Cells In Vitro
… provide evidence that autocrine production of IGF-I modulates tight junction permeability and (2) demonstrate the ability of IGFBPs to regulate IGF-I delivery across cell layers. To meet the first objective, parental and IGF-I secreting bovine mammary epithelial cells were tested for cell layer …
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The role of receptor tyrosine kinase signalling in HER-2-positive cells and trastuzumab (Herceptin) resistance in breast cancer
… breast cancer. Signalling through alternative receptor tyrosine kinases, such as insulin-like growth factor I receptor (IGF-IR), has been implicated in resistance to Tmab. The main aim of this study was to investigate mechanisms of resistance and in particular the role of IGF-IR in resistance …
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Isolation and functional analysis of differentially expressed genes in human prostate cancer
… können. Aus der Literatur ist bekannt, dass der Insulin-like growth factor I receptor (IGF-IR) eine wichtige Rolle in der zellulären Homöostase von Prostatakarzinomen spielt. Daher wurde die antisense-RNA-Strategie genutzt, um die endogene IGF-IR Genexpression in menschlichen Prostatakarzinom …
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Obesity and Aggressive Prostate Cancer: Bias and Biology
Obesity is suspected to be a risk factor for aggressive PC due to its associations with altered circulating levels of metabolic and sex steroid hormones involved in prostate development as well as oncogenesis. However, the current observational evidence linking obesity to aggressive PC is …
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Intrauterine Wachstumsretardierung (IUGR) mit ARED-Flow in der Dopplersonographie der Arteria umbilicalis : molekulargenetische Analyse der Gene IGF-I und IGF-IR
… a possible role of mutations of the genes IGF-I (Insulin-like Growth Factor-I) and IGF-IR (Insulin-like Growth Factor-I Receptor) in the pathogenesis of intrauterine growth retardation/ restriction (IUGR) with ARED (Absent or Reversed EndDiastolic)-flow in the Doppler ultrasonography of the …