Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Insulin-like growth factor 2 (IGF2)"”.
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Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma
… microarray studies were conducted. Hepatocyte growth factor (HGF), interleukin 1 beta (IL1Β), and insulin-like growth factor 2 (IGF2) were elucidated as genes that were significantly expressed in GD12 placenta. These genes are similar in that they are all connected to the Jak-Stat signaling …
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Molecular Regulation of Maternal Hepatic Adaptations to Pregnancy
… (Ascl1), a basic helix-loop-helix transcription factor essential for neuronal development, is highly activated in maternal hepatocytes during the second half of gestation in mice. Our aim is to investigate whether and how Ascl1 plays a pregnancy-dependent role. We deleted the Ascl1 gene in the …
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Comparison of the molecular phenotypes of pigs carrying different IGF2 alleles at four developmental time points
A single nucleotide polymorphism in insulin-like growth factor 2 (IGF2 intron3-G3072A) is associated with greater muscle mass and decreased subcutaneous fat deposition in pigs carrying a paternal copy of the A allele (Apat). While many studies have focused on the differences in between the gross …
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Characteristics of decidual macrophages and Hofbauer cells in placentas of HIV positive women on antiretroviral therapy
… plasticity of these cells. Human Coagulation Factor XIIIa1 (FXIIIa1) and Insulin-like growth factor 2 (IGF2) were identified as potential novel markers of HCs and decidual macrophages respectively, however, further validation is required. There is a paucity of data on the characteristics of …
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The role of the Igf2/H19 locus in regulating murine placental endocrine capacity
… produces an abundance of hormones and signalling factors that adapt maternal metabolism to support fetal growth. In mice, these functions are performed in two distinct placental regions, the transport labyrinth zone (Lz) and the endocrine junctional zone (Jz). Insulin like growth factor 2 (Igf2) …
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The Role of Mouse Placental Endocrine Function on Offspring Metabolic Health
… only by transporting nutrients to support fetal growth, but also by secreting hormones, which alter the maternal metabolism. Disturbances in placental endocrine function may lead to adverse fetal outcomes and pregnancy complications, such as gestational diabetes mellitus (GDM). The Developmental …
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Regulation of skeletal muscle growth and gene expression by insulin-like growth factors and myostatin
Insulin-like growth factor 2 (IGF2) is a maternally imprinted growth factor that is thought to primarily promote prenatal skeletal muscle growth. A SNP within intron 3 of IGF2 identified as IGF2-intron3-G3072A has a considerable impact on lean yield as a result of increased postnatal IGF2 …
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Creation and characterization of mice with a mutation disrupting binding of a transcriptional repressor of insulin-like growth factor 2
Insulin-like growth factor-2 (IGF2) is a key regulator of myogenesis as it promotes differentiation of myoblasts during embryonic and fetal development. A single nucleotide polymorphism (SNP) identified in pigs in intron 3 of IGF2 disrupts a binding site for the transcriptional repressor ZBED6 …
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The impact of mouse placental endocrine function on fetal resource allocation and adult offspring health
… for secreting hormones that induce maternal insulin resistance and transports the nutrients available to support fetal growth and metabolic demand. Disturbances in placental endocrine function may lead to pregnancy complications such as gestational diabetes mellitus (GDM) and intrauterine …
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The role of Igf2 methylation and histone ubiquitination in age-related memory decline
… of adults over the age of 70 and is a major risk factor for developing dementia and Alzheimer's disease (AD). The hippocampus is one of the major brain regions associated with memory formation, and is one of the first regions impacted in dementia and AD. Although research indicates that molecular …
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IGF2R: A NEW PLAYER IN THE INSULIN LIKE GROWTHFACTOR 2 (IGF2) PATHWAY SUSTAINING ADRENOCORTICAL TUMOURS CELL GROWTH
… preclinical studies. Of particular interest, the insulin-like growth factor 2 (IGF2), overexpressed in the majority of ACC, is a growth factor responsible for the autocrine proliferative loop that sustains ACC growth. In the IGF2 system, two well addressed tyrosine-kinase receptors, IGF1R and IR, …
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Regulation of skeletal myogenesis by the mTOR signaling network
… to form multinucleated myofibers. Post-natal growth, repair, and maintenance of skeletal muscle are dependent on muscle satellite cells, which in response to stimuli differentiate and fuse to form new myofibers. Developmental or post-natal failure of skeletal myogenesis results in diverse …