Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 249 for “"Insulin-like growth factor"”.
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Investigations of Insulin-Like Growth Factor I Cell Surface Binding: Regulation by Insulin-Like Growth Factor Binding Protein-3 and Heparan Sulfate Proteoglycan
… to gain insight on how cellular activation by a insulin-like growth factor (IGF-I), in the presence of insulin-like growth factor binding protein-3 (IGFBP-3), is influenced by heparan sulfate proteoglycans (HSPG). Initial research will be presented, assumptions and hypotheses that were included …
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Insulin-like growth factor receptor activity in cancer biology & therapy responses
The Insulin-like Growth Factor 1 Receptor (IGF-1R) has an essential function in normal cell growth and in cancer progression. However, anti-IGF-1R therapies have mostly been withdrawn from clinical trials owing to a lack of efficacy and predictive biomarkers. IGF-1R activity and signalling in …
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The Role of Insulin-Like Growth Factor-I in Myeloid Cell Differentiation
… acetate esterase of mature macrophage. Cell growth and cell cycle analysis revealed that IGF-I promoted cells advancing through the cell cycle as well as enhances macrophage differentiation. Western blot analysis demonstrated that IGF-I-induced proliferating cells express high cyclin E and …
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Novel recombinant protein constructs for improved insulin-like growth factor-1 delivery
… were designed to improve the delivery of insulin-like growth factor-1 (IGF-1). The IGF-1 sequence was subcloned into a HisMax plasmid and expressed at low levels by transient transfection in 293 cells. Site-specific mutagenesis was used to insert all four construct sequences into the IGF-1 …
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Insulin-like Growth Factor Binding Proteins in the Plasma of Growing Horses
Insulin-like growth factor binding proteins (IGFBP) are modulators of insulin-like growth factor I (IGF-I), which functions as a regulator of cartilage and bone development. Rapid growth and high starch diets have been associated with increased circulating concentrations of IGF-I, which lead to …
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Nutritional Regulation of Serum Insulin-Like Growth Factor-I Concentration in Cattle
… was to understand the mechanisms by which serum insulin-like growth factor-I (IGF-I) is regulated by nutritional intake in cattle. Two studies were conducted to achieve this objective. In the first study, effects of feeding levels on basal and growth hormone (GH)-stimulated serum concentrations …
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Hormonal factors and insulin-like growth factor-1 in North American postmenopausal women
… exposure on breast cancer risk remain unclear. Insulin-like growth factor-1 (IGF-1) levels have been positively associated with breast cancer and are a potential mechanism. Objectives: The objectives of this thesis are: 1) to explore whether the reproductive risk factors and the lifetime …
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The Role of Insulin-Like Growth Factor Binding Protein 3 in Mitochondrial Homeostasis
Pages 15-102 are misnumbered as pages 14-101, pages 103-155 are misnumbered as pages 100-152, and pages 156-192 are misnumbered as pages 151-187.
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Characterization of insulin-like growth factor-I system gene expression in pcd mice
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The differential Role of Insulin-like Growth Factor-1 Isoforms in Skeletal muscle
Insulin-like growth factor-1 (IGF-1) has pleiotropic effects on various tissues during pre- and postnatal development by stimulating proliferation and differentiation, and plays a major role in hypertrophy and tissue remodeling in the fetal, perinatal, and adult organism. In skeletal muscle the …
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Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer
The evolutionarily conserved Insulin-Like Growth Factor 1 (IGF-1) signalling pathway is essential for growth and development and may facilitate cancer progression. While IGF-1 mediates mitochondria protection in some pathologies, whether it is essential for mitochondrial homeostasis in tumour cells …
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Characterization and Regulation of Insulin-Like Growth Factor-Imrna Transcripts in Myeloid Cells
Using reverse transcription and PCR amplification, cDNA fragments corresponding to IGF-I Ea and Eb mRNA transcripts were detected in all murine immune cell types. The identity of these sequences was confirmed by cloning and sequencing. Macrophages had 20 to 40 fold higher levels of IGF-I mRNA than …
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Insulin-like growth factor-1 stimulates glycogen synthesis in the bovine uterine epithelium
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo terms
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Growth Hormone and Nutritional Regulation of Insulin-Like Growth Factor-I Gene Expression
… objectives of this research were to characterize insulin-like growth factor-I (IGF-I) gene expression in cattle, to determine how IGF-I gene expression is affected by nutritional intake and growth hormone (GH) in cattle, and to identify the regulatory DNA region that mediates GH stimulation of …
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The oxidative folding of insulin-like growth factor-I analogues / by Steven John Milner.
This thesis investigates the effect of mutations and an N-terminal extension on the oxidative folding pathway of IGF-I, analyses the structure of the stable mis-folded molecule in terms of its biological interactions, examines the kinetics of the late stages of oxidative folding and finally …
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Cloning and characterization of ovine insulin, insulin-like growth factor-I and -II genes
Genes encoding ovine insulin like growth factor-I (oIGF-D), -II (oIGF-II) and insulin were cloned, sequenced and characterized. The olGF-I gene contains six exons spanning greater than 30 kilobases. Class 1 and class 2 oIGF-I transcripts contained exons 1 and 2 alternatively-spliced to exon 3, …
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Regulation of the Insulin-like Growth Factor System by Retinoic Acid in Human Osteoblast Cells
… acid (RA) is an important regulator of growth and differentiation in many cell types, including bone. However, its effects on human osteoblast cell growth and differentiation have not been well studied. Therefore, I investigated the effect of RA on proliferation and differentiation of …
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Progesterone Regulation of Insulin like-Growth Factor : Binding Protein-5 Gene Transcription in Human Osteoblasts
<p>Insulin-like growth factor binding protein-5 (IGFBP-5) is produced by osteoblasts and potentiates IGF mitogenic actions in osteoblast cultures. Progesterone (PG) increases osteoblast proliferation and increases osteoblast IGFBP-5 expression. Mechanisms underlying PG induction of IGFI3P-5 …
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Functional analysis of insulin-like growth factor binding protein -4 and -6 in transgenic mice
Insulin-like growth factors (IGF-I and IGF-II) are expressed in many cell types and tissues and act in endocrine, autocrine or paracrine manner to regulate cellular proliferation, survival and differentiation. IGF actions are initiated upon binding to the type I IGF receptor (IGF-IR) and are …
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