Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Insulin-like Growth Factor-I (IGF-I)"”.
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Overexpression of ovine insulin-like growth factor-I (IGF-I) in the mammary glands of transgenic mice
… to its own development by the production of insulin-like growth factor-I (IGF-I). To generate a model for investigation of the effects of enhanced IGF-I synthesis in the mammary gland, six transgenic founder mice were produced by microinjection of a cDNA sequence encoding ovine IGF-I (oIGF-I) …
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Quantification of the Binding of Insulin-like Growth Factor-I (IGF-I) and IGF Binding Protein-3 (IGFBP-3) Using Surface Plasmon Resonance
Insulin-like growth factor-I is a small growth factor known to signal in a variety of mammalian cells through the IGF-I cell surface receptor (IGF-IR). A unique feature of the IGF-I system is the regulation of this binding by soluble IGF binding proteins. Recent studies from our laboratory show …
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Autocrine mechanisms of action of insulin-like growth factor-I (IGF-I) and hormonal regulation of expression of IGF-finding proteins in mammary epithelial cells
… cellular mechanisms that regulate expression of insulin-like growth factor-I (IGF-I) and IGF-binding proteins (IGFBPs) genes in mammary epithelial cells. To test the hypothesis that IGF-I affects growth of bovine mammary epithelial cells through an autocrine and/or paracrine pathway, several cell …
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The effect of insulin-like growth factor-I (IGF-I), and an IGF-I-like factor secreted by human lung fibroblasts, on the growth of human lung carcinoma cells in vitro
The concentration of insulin-like growth factor I (IGF-I) in tissue taken from human non-small cell lung carcinoma (NSCLC) is 1.4- to 7-fold higher than the concentration of IGF-I in the surrounding normal lung tissue and therefore IGF-I may be involved in the growth of NSCLC. In this study it was …
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Molecular Mechanisms of Growth Hormone Induced Muscle Hypertrophy
… the response of different aged rats to a growth hormone secreting tumor, (2) examine the presence and significance of extrahepatic insulin-like growth factor I (IGF-I) and IGF-II mRNA in rats bearing GH$\sb{3}$ tumors, and (3) evaluate the presence of oncogene mRNA in muscles from rats …
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Axotomy and Regeneration of the Rat Facial Nerve: A Histomorphometric Study of the Facial Nucleus, Nerve and Orbicularis Oculi Muscle in an Experimental Model of Facial Paralysis
… and local administration via osmotic pump of insulin-like growth factor-I (IGF-I). Results demonstrated that IGF-I (50 $\mu$g/ml) enhanced recovery of function, its time of onset, as well as the histomorphometric profile of the nerve graft. While results were encouraging, full recovery of …
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Somatolactogenic hormones and interferon-gamma as regulators of neutrophil activation
… the role of two somatolactogenic hormones, growth hormone (GH) and prolactin (PRL), as well as the classic phagocyte activator, interferon-gamma (IFN-$\gamma$), in activating polymorphonulear neutrophils (PMN) from pigs, cows, rats and humans to kill Escherichia coli and secrete superoxide …
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In vitro comparison of equine tendon- and bone marrow-derived cells expanded with FGF-2 prior to culturing with tendon matrix and IGF-I
… performed to determine the effects of fibroblast growth factor-2 (FGF-2) on monolayer expansion of equine tendon- and bone marrow-derived cells prior to culture with autogenous acellular tendon matrix and insulin-like growth factor-I (IGF-I). Progenitor cells were isolated from six young adult …
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Development of a technique for measuring insulin-like growth factor-I in swine:application to the study of the IN VIVO and IN VITRO effects of growth hormone in neonatal pigs
The relationship between porcine growth hormone (pGH) and insulin-like growth factor-I (IGF-I) in swine was investigated. IGF-I levels were measured by radioimmunoassay (RIA) with an antisera specific for human IGF-I after ultrafiltration of acidified samples. Ultrafiltration quantitatively …
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Growth and the Somatotropic Axis in Young Thoroughbreds
… between diet, somatotropic axis, and growth. Growth hormone (GH) and insulin-like growth factor I (IGF-I) are factors in the somatotropic axis, and important to development of growth cartilage in the young animal. The entire study was divided into four main experiments. Characteristics …
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In Vitro Binding and Transport Regulation by Endothelial Cells: Preliminary Studies looking at FIX and IGF-I
… study investigates how the recombinant source of Factor IX (FIX), a blood coagulant protein used in the treatment of Hemophilia B, impacts surface ligand binding (FIX to its specific receptors) to bovine aortic endothelial cells (BAECs). Competitive binding experiments between 125I-FIX and FIX …
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Insulin-like growth factor-I in growing horses and RNA isolation from small articular cartilage samples
… of plasma (PL) and synovial fluid (SF) total insulin-like growth factor-I (IGF-I) concentrations, as well as their association with measurements of skeletal growth in Thoroughbred horses. Horses were randomly assigned to one of two dietary treatment groups and fed diets with either a high or …
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Tissue Engineering the TMJ Condyle using Human Umbilical Cord Mesenchymal Stromal Cells
… mature hyaline cartilage cells, scaffolds, and growth factors were integrated to create TMJ condylar bone and cartilage in vitro to substitute for deteriorated native tissues. hUCMSCs were successfully differentiated along chondrogenic and osteogenic lineages in a 3D biomaterial-based …
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Exploring Chondrocyte Integrin Regulation of Growth Factor IGF-I Expression from a Transient pAAV Vector
Insulin-like Growth Factor I (IGF-I) is a growth factor that stimulates both mitogenic and anabolic responses in articular chondrocytes. While it has been shown that exogenous IGF-I can regulate chondrocyte integrins, little is known regarding regulatory effects of IGF-I produced from a transiently …
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Regional Fat Distribution, Physical Activity and Hormonal Factors in Adults With Type 2 Diabetes
… free testosterone (FT), estradiol and insulin-like growth factor I (IGF-I) were assessed by radioimmunoassay. Sex-hormone binding globulin (SHBG), and androgeneicity index (AI) were calculated from testosterone and FT. Leisure, occupational, household, non-leisure and total physical …
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Effects of Milk Replacer Composition on Measures of Mammary Development in Holstein Heifer Calves
… of mammary parenchyma (PAR) and fat pad (MFP), growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis gene expression, and putative mammary epithelial stem cells. The hypothesis was that diet during the pre-weaning period alters the development, persistence, or activity of populations of …
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Molecular aspects of the link between obesity and endometrial cancer.
… the exact role of intracellular signalling factors within adipose tissue, in the development of endometrial cancer, is still unclear. This project aimed to partially address this lack of understanding by carrying out a systematic review / meta-analysis of primary studies related to the role …
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Hormonal therapies during recovery from neonatal malnutrition in rats
Malnutrition leads growth stunting and low serum insulin-like growth factor-I (IGF-I) concentration in humans and animals. Nutritional repletion alone does not support the full body wt recovery or normalize serum IGF-I concentrations. As growth-promoters and anabolic agents, growth hormone (GH) and …
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Molecular interactions among insulin-like growth factor, its receptor and binding proteins on myeloid cells
… changes could be reversed by implanting the growth hormone (GH) secreting cells, GH$\sb3$. To understand the molecular mechanism by which insulin-like growth factor-I (IGF-I), a mediator of GH's action, acts on cells of immune system, the expression of IGF-I, IGF-I receptor (IGF-IR) and IGF …
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Chronic Shear Stress Effects on Endothelial Cell Response
… for real time strain measurement of the growth fibers used in our culture system, and found that no significant strains were occurring during shear treatment. After characterization of the mechanical environment of the cells, we focused the scope of our research on metabolism of …
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