Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Insulin-Like Growth Factor II"”.
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Role of JAK3 in Myogenic Differentiation
… differentiation is regulated by transcription factors, including members of the myogenic regulatory factors (MRFs) family and many signaling pathways. The JAK1 and JAK2 pathways are known to each have different effects on myoblast proliferation and differentiation; however, the role of JAK3 in …
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Molecular aspects of the link between obesity and endometrial cancer.
… the exact role of intracellular signalling factors within adipose tissue, in the development of endometrial cancer, is still unclear. This project aimed to partially address this lack of understanding by carrying out a systematic review / meta-analysis of primary studies related to the role …
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Investigating the Role of DIS3L2 in Perlman Syndrome and Wilms Tumor
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Resveratrol Regulates IGF- II and Cathepsin D in Breast Cancer Cells
… but has been associated with breast cancer cell growth and cell death. RSV binds to estrogen receptors (ER) and functions as a mixed estrogen agonist/antagonist. The mechanism by which RSV regulates breast cancer growth is largely unknown, but it likely targets factors regulated by estrogens. …
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Regulation of the Insulin-like Growth Factor System by Retinoic Acid in Human Osteoblast Cells
… acid (RA) is an important regulator of growth and differentiation in many cell types, including bone. However, its effects on human osteoblast cell growth and differentiation have not been well studied. Therefore, I investigated the effect of RA on proliferation and differentiation of …
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A study on the interactions of synthetic IGF-II analogues with the type 1 IGF and insulin receptors.
Insulin-like growth factor II (IGF-II) is a unique regulatory peptide containing 67 residues and three disulfide bonds. It binds with high affinity to three receptors, the insulin receptor (IR), the type 1 insulin-like growth factor receptor (IGF-1R) and the We 2 insulin-like growth factor receptor …
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Discovery of Peptide and Aptamer Ligands for Targeted Drug Delivery to Hepatic Stellate Cells
… is to identify peptide ligands targeting the insulin like growth factor II receptor (IGFIIR), which is overexpressed in HSCs during liver fibrogenesis. A combinatorial phage display biopanning against IGFIIE protein- and HSC-T6 rat hepatic stellate cells was conducted to identify phage/peptide …
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Microphysiometry Studies of Rapid Binding of Insulin-Like Growth Factor I by Parental and Transfected Mammary Epithelial Cell Lines
… in the U.S. today. Members of the family of insulin-like growth factors (IGFs) are proposed to play a major role in the development and subsequent uncontrolled proliferation of breast cancer cells. Insulin-like growth factor-I (IGF-I) is known to be a potent mitogen for mammary epithelial …