Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"Insulin trafficking"”.
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The Role of Sox17 in Normal and Pathological Beta Cell
… discovered a novel role for Sox17 in regulating insulin trafficking and secretion in normal and pathological β cells. Loss of Sox17 throughout pancreas development in a wildtype background resulted in mice with prediabetes. These mice had higher proinsulin protein content in the ER of the islet …
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β-cell dysfunction in Huntington's disease
… the functional similarities of neurons and the insulin secreting pancreatic β-cell, pathological mechanisms may be shared by both cell types and account for neuronal as well as endocrine dysfunction. Hence, finding the mechanisms behind β-cell dysfunction in HD could identify potential …