Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 167 for “"Insulin secretion"”.
-
Small gtp-binding proteins in insulin secretion
… failure which is characterized by defective insulin secretion and resistance to insulin. Understanding the molecular events leading to Glucose-stimulated insulin secretion [GSIS] might serve as therapeutic potential towards diabetes. GSIS involves interplay between small G-proteins and their …
-
Epigallocatechin Gallate in the Regulation of Insulin Secretion
… mass and beta-cell dysfunction lead to impaired insulin secretion, and ultimately worsen glycemic control. Green tea has drawn wide attention due to its possible health-promoting properties, including enhancement of beta-cell function. We assessed the acute and relative long-term effects of …
-
Shared Metabolic Pathways in Fuel-Stimulated Insulin Secretion
<p>Insulin secretion is a fundamental process of pancreatic beta-cells required for the maintenance of glucose homeostasis. Fuel-stimulated insulin secretion occurs in proportion to the rate of metabolism of fuel substrates, yet the signals generated by metabolism of these secretagogues are …
-
Mechanisms of defective insulin secretion in type 2 diabetes
Defective insulin secretion from the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. This thesis uses a combination of gene network analysis and cell-physiological …
-
ADP regulation of insulin secretion and beta-cell apoptosis
… the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of …
-
Lipid metabolism in the pancreatic beta-cell. Implications for insulin secretion.
… metabolism with regard to beta-cell function and insulin secretion. Lipids are known to play a crucial functional role in the pancreatic beta-cell, where they are essential for adequate hormone release, but may also exert a long-term toxic effect, leading to beta-cell dysfunction. Our studies in …
-
Coupling mechanisms of insulin secretion - roles of mitochondrial metabolism and cAMP.
… in the western world. It is characterized by insulin resistance and defects in insulin secretion. Insulin resistance is tightly linked to obesity, and usually precedes the onset of type 2 diabetes. When insulin resistance develops, the pancreatic beta-cells compensate by in¬creasing their …
-
THE ROLE OF PHOSPHODIESTERASE 3B IN CAMP-MEDIATED REGULATION OF INSULIN SECRETION
… by various combinations of ?-cell failure and insulin resistance leading to hyperglycemia and glucose intolerance. In order to maintain glucose tolerance in the insulin resistance state, increased insulin secretion is a requirement and it is because of inadequate islet adaptation that glucose …
-
Pyruvate Cycling Pathways and Glucose-Stimulated Insulin Secretion in Pancreatic Beta Cells
Pancreatic β-cells secrete insulin in response to glucose. Intracellular glucose metabolism drives a cascade of events, including ATP production, calcium influx, and insulin processing, culminating in insulin granule exocytosis. However, insulin secretory mechanisms are incompletely understood. …
-
Effect of hypoxia on insulin secretion and viability of pancreatic islet tissue
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1990.
-
Role of the Vitamin D Receptor in Insulin Secretion and Beta Cell Function
… Vitamin D results in enhanced glucose-stimulated insulin secretion (GSIS). This response is VDR-dependent, as no VitD-mediated change in GSIS is observed in islets obtained from Vdr-null mice. However, VitD causes no changes in gene expression of any of the major islet hormones, nor does it change …
-
Assessment and Treatment of Impaired Insulin- Secretion and Action in Type 2 Diabetes
… characterised by varying degrees of defect in insulin secretion and insulin sensitivity and associated with increased morbidity and mortality. Optimal glycaemic control reduces the progression of diabetic complications. Over time, there is a steady deterioration of glycaemic control that raises …
-
The Role of the Parotid Salivary Glands in the Regulation of Insulin Secretion
… for effects on fasting plasma glucose and insulin or effects on intravenous glucose tolerance in male Sprague-Dawley rats. Basal glucose and insulin were substantially elevated as a result of the stress of translocation in large animals, but were not altered in small animals. A rise in …
-
Criticality control of insulin release: a novel alternative for detailed modelling of insulin secretion
… of the dynamic components of the glucose-insulin system has posed a major challenge in the field of physiological modelling for the past six decades. Early stages in development focused on a descriptive approach where mathematical complexity was usually compromised, causing …
-
Genistein-Induced Potentiation Effect on Glucose-Stimulated Insulin Secretion (GSIS) in INS-1 β-cells
Impaired secretion of insulin as well as insulin resistance is a critical characteristic of type 2 diabetes. Thus, correction of the deficient secretion of insulin as well as improvement of insulin action is an important target for prevention of overt type 2 diabetes. Sulfonylureas have been used …
-
Search for Insulin Secretion Modulators, Novel Functions of WNK Signaling and Intramolecular Signal Transduction in ERK2
In this dissertation, the regulation of insulin secretion from pancreatic beta cells, WNK1 pathway involvement in cell migration, angiogenesis, breast cancer, and other processes, as well as ERK2 intradomain communication are discussed. Each chapter is dedicated to a separate project, but the …
-
Studies on the influence of sex hormones on glucose tolerance and insulin secretion in the rat
… of glucose tolerance and an elevation of plasma insulin levels.This interpretation is substantiated by observations that treatment of ovariectomized females with oestradiol, progesterone and a preparation of gonadotrophins produces similar alterations of glucose metabolism and the circulating …
-
A Study of Glucose Stimulus Insulin Secretion Coupling using Lean and Obese Mouse Islets of Langerhans
Glucose-stimulus insulin secretion coupling has been investigated using isolated islets of Langerhans from lean homozygous (+/+) and genetically obese hyperglycaemic (ob/ob) mice. Streptozotocin inhibition of the insulin response to glucose but not glucagon suggests glucose sensitive sites and …
-
Regulation of Insulin Secretion in Relation to Nitric Oxide, Carbon Monoxide and Acid alpha-Glucoside Hydrolase Activities
The main stimulus for insulin secretion is elevated blood glucose levels. In this thesis the aim was to study less well-known systems involved in the complex regulation of glucose-stimulated insulin release, emphasizing the role of the lysosomal/vacuolar system and the associated glycogenolytic …
Page 1 of 9