Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Insulin analogues"”.
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A cost-utility and budget impact analysis of long-acting insulin analogues, (determir, glargine and degludec) for the treatment of adults with T1DM in South Africa
… condition that is managed with administered insulin. Intermediate- to long-acting insulin represents the basal insulin constituent of the total insulin used in treating T1DM and has received much research and development over the years. In South Africa, intermediate-acting Neutral Protamine …
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Injectable Systems for Long-Lasting Insulin Therapy
… of 2040 causing significant economic burdens. Insulin therapy has been the mainstay of diabetes treatment since its discovery in 1922. However, insulin is an unstable peptide with a half-life of only 4-6 min which poses significant challenge in prolonging duration of action of insulin. …
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Untersuchungen zum Insulinbindungsbereich des Insulin-IGF-I-Rezeptorsystems mittels kovalenter Markierung
… this thesis was to provide information about the insulin binding region und stoichiometry of the insulin and the IGF-I receptor as well as of two chimeric insulin-IGF-I receptors. To achieve this two photoreactive insulin analogues, B29-Azidotetrafluorobenzoyl-biocytinyl-Insulin …
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Optimisation of the Investigation of Antibody-Mediated Dysglycaemia
Two rare and severe disorders of insulin action, namely insulin autoimmune syndrome (IAS) and type B insulin resistance (TB-IR), are caused by pathogenic antibodies against insulin or the insulin receptor, respectively. These may arise in isolation or may complicate management of pre-existing …
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Pre-clinical development of cyclodextrin-based nanoparticles for oral delivery of protein/peptide drugs-in vitro and in vivo evaluation
… including three different drug cargos, two human insulin analogues (insulin glulisine and Lola insulin) and the GLP-1 analogue named as liraglutide. In the first stage of the preclinical development of these formulations, the fabrication process of the three prototypes containing the different …
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Trends in Prices of Insulin Marketed in the US
… of this study were to assess trends in insulin products prices in the period January 1983-July 2019, and to compare the price, acquisition costs and reimbursement amount of insulins available in the US.</p> <p><strong>DATA AND METHODS:</strong> Data of insulin products marketed in the US …
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Investigation into reliability and performance of an implantable closed-loop insulin delivery device
An implantable closed-loop insulin delivery device (INsmart device) containing a glucose responsive gel has been developed within the INsmart research group, over a period of 10 years, to mimic pancreas. In this thesis, the reliability and performance capability of the INsmart device was studied …