Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 221 for “"Insulin Sensitivity"”.
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Dietary Protein Regulation of Insulin Sensitivity and Glucose Homeostasis
… control by reducing the regulatory role of insulin and peripheral disposal of dietary CHO and upregulating hepatic gluconeogenesis under fasted conditions.
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Effect of Nedd4 Haploinsufficiency on Insulin Sensitivity, Adiposity and Neuronal Behaviors
… Nedd4-deficient mice displayed moderate insulin resistance and mild hyperinsulinemia. These findings are consistent with others’ studies in which depletion of Nedd4 in mouse embryonic fibroblasts (MEFs) led to a decline in insulinlike growth factor I (IGF-1) and insulin signaling.</p> …
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Salivary Biomarkers of Acute Stress and Insulin Sensitivity in Nonhuman Primates
… study were to 1) validate measures of salivary insulin, cortisol and sAA and 2) explore relationships between these measures. Saliva was collected twice daily for two weeks in gorillas (Gorilla g. gorilla), mangabeys (Cercocebus chrysogaster), red ruffed lemurs (Varecia rubra) and mongoose …
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The impact of glucocorticoids upon the insulin sensitivity of skeletal muscle
… obesity, hypertension, proximal myopathy, insulin resistance and in some cases overt type 2 diabetes (T2D). However, the precise molecular mechanisms responsible for these observation have not been defined in detail. We have shown that GCs reduce the insulin sensitivity of skeletal muscle …
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The Effects of Macronutrient and Micronutrient Diet Manipulation on Human Insulin Sensitivity
Insulin resistance leading to diabetes is currently at pandemic levels. The associated costs to society and burden on health providers are incalculable. Aside from type 2 diabetes and cardiovascular disease, it is now clear that insulin resistance (and resultant hyperinsulinism) is implicit with …
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Role of Ceramidase in Regulating Hepatic Lipid Metabolism and Whole Body Insulin Sensitivity
… was shown to be associated with both hepatic insulin resistance and NAFLD. We recently demonstrated that the adipose-derived secretory factor adiponectin promotes an increase in ceramide catabolism, which is dependent on adiponectin receptors 1 and 2. The associated ceramidase activity …
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The role of brown adipose tissue on substrate metabolism and insulin sensitivity in humans
… energy homeostasis, glucose and lipids kinetics, insulin sensitivity, and thermoregulation in humans. To this end, we studied men with (BAT+) or without (BAT-) detectable BAT under prolonged mild cold and thermoneutral conditions using infusion of stable isotopic tracers, …
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Measuring insulin sensitivity and the effect of alternative dietary interventions and exercise on metabolic control
… tolerance test can be a reliable tool to measure insulin sensitivity following adequate dietary and exercise control. Acute and chronic cinnamon ingestion was shown to improve insulin sensitivity. Feeding frequency was found to alter insulin and ghrelin responses and relationships following …
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How to Activate your Lazy Fat: Exercise induced mechanisms to improve insulin sensitivity in obese humans
Contains fulltext : 326574.pdf (Publisher’s version ) (Open Access)
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Influence of Vitamin D Receptor Gene Polymorphisms on Changes in Insulin Sensitivity with Aerobic Exercise Training
… of the vitamin D receptor gene on changes in insulin sensitivity with aerobic exercise training in men and women at increased risk for type 2 diabetes mellitus (T2DM). Subjects were genotyped and underwent oral glucose tolerance tests before and after six months of training. Due to …
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Angiotensin II receptor blockade and insulin sensitivity in overweight and obese adults with elevated blood pressure
… risk of developing hypertension. Whole-body insulin sensitivity is reduced in obesity, resulting in insulin resistance and increased risk of type 2 diabetes. One possible mechanism contributing to insulin resistance in obesity hypertension is renin-angiotensin system (RAS) overactivation. The …
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The Effect of Post-Exercise Caffeine and Chlorogenic Acid Supplementation on Blood Glucose Disposal and Insulin Sensitivity
… beans that alter blood glucose disposal and insulin sensitivity. Caffeine has been shown to decrease glucose disposal and insulin sensitivity when taken 60 minutes prior to an oral glucose tolerance test in humans, whereas chlorogenic acid has been shown to increase glucose disposal and …
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Systemic Insulin Sensitivity and Skeletal Muscle Akt Signaling in Rats Artificially Selected for Low and High Aerobic Capacity
… capacity is associated with reduced systemic insulin sensitivity via skeletal muscle insulin signaling. After 34 generations of selective breeding, high aerobic capacity (HCR) rats exhibited an 8-fold increase in running distance vs low aerobic capacity (LCR) rats (n=14 per group). LCR rats …
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The Effect of a Probiotic Supplement on Insulin Sensitivity and Skeletal Muscle Substrate Oxidation during High Fat Feeding
… gain and body fat accretion while improving insulin sensitivity in animal models. Objective: Our objective was to determine the effects of the probiotic VSL#3 on body weightand composition, skeletal muscle substrate oxidation, and insulin sensitivity and during 4 weeks of high-fat, …
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Understanding adipokine secretion and adipocyte-macrophage cellular interactions, in search for the molecular basis of insulin sensitivity and resistance
… and leptin are two adipokines that control insulin sensitivity and energy balance. In spite of their importance, there are still questions about their secretion. I hypothesized that leptin and adiponectin follow different secretory routes. I found adiponectin localized in Golgi and the trans …
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The role of metabolic rate and substrate utilization in the maintenance of body weight, body composition and insulin sensitivity
… fitness (CRF), metabolic flexibility and insulin sensitivity also contribute towards reducing obesity-associated risk factors. While energy restriction alone results in significant weight loss, exercise-only interventions provide small amounts of weight loss and prevent weight gain, while …
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The Relationship Between Vitamin D Status of Adult Women and Diet, Sun Exposure, Skin Reflectance, Body Composition, and Insulin Sensitivity
… vitamin D from sun exposure. Fasting serum insulin levels were significantly, positively correlated with BMI (r = 0.83, p < 0.0001), and sun exposure index (Body Surface Area x Minutes of Direct Sunlight) was significantly, positively correlated with serum 25(OH)D levels (fall weekend SEI: r …
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The effect of an exercise intervention on insulin sensitivity, insulin secretion and insulin clearance in black obese South African women
… Black African populations present with low insulin sensitivity (SI) and hyperinsulinemia, the latter due to high insulin secretion and reduced clearance. In addition, they exhibit lower levels of central and ectopic fat, compared to their white counterparts, contradicting the known …
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Influence of physical fitness on gut microbiota profile and its relationship with insulin sensitivity in patients with type 2 diabetes mellitus
… por hiperglucemia y resistencia a la insulina y afecta a millones de personas en todo el mundo. Recientemente se ha descubierto que la T2DM se relaciona con la microbiota intestinal, siendo la disbiosis de la microbiota un factor de riesgo para desarrollar resistencia a la insulina. …
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