Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Insulin Intolerance"”.
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Feeding butter with elevated content of trans-10, cis-12 conjugated linoleic acid to obese-prone rats impairs glucose and insulin tolerance
… have shown to contribute to the development of insulin resistance. We created butter from cows with subacute ruminal acidosis (SARA), a condition that decreases the pH of a dairy cow’s rumen and increases CLAt10c12 10-fold making this an enriched naturally occurring source of CLAt10c12. We …
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Evidence for the role of delta-6-desaturase in the development of cardiometabolic disease
… composition observed in heart failure and T2D/insulin resistance are a result of increased metabolism of polyunsaturated fatty acids (PUFAs) through D6D, the rate limiting enzyme in the PUFA metabolism pathway. Pharmacological inhibition of D6D with SC-26196 reversed the aberrant fatty acid …
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Investigating the role of estrogen deprivation and diet-induced insulin resistance on markers of amyloid-β production and degradation in the brain
… Disease (AD). Furthermore, diet-induced insulin resistance has also been shown to increase Aβ; however, whether this process is exacerbated with the loss of estrogen remains unknown. We aimed to investigate the effects of estrogen loss on amyloid production and degradation pathways, as …
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Complex Heterocycles as Mitochondrial Uncouplers
… that SHM20519115 prevented glucose and insulin intolerance in mice. Taken together, our investigations support the utility of mitochondrial uncouplers for the treatment of obesity and other metabolic disorders.