Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Institute of Immunology"”.
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Characterisation of the role of human Evolutionary Conserved Signalling Intermediate in Toll (ECSIT) in Mitogen Activated Protein Kinase (MAPK) signalling
… There is a striking difference in the role of hECSIT and mECSIT in the activation of inflammatory transcription factors NFκB, ELK-1 and AP-1; with mECSIT augmenting their activation and hECSIT having an inhibitory role. In addition I demonstrate that hECSIT specifically targets the p42/44 …
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Proteomic analysis of TRIF interactome and functional characterisation of novel TRIF interacting proteins
… molecular structures shared by a wide range of pathogens, known as pathogen-associated molecular patterns (PAMPs). TIR domain-containing adaptor inducing IFN-β (TRIF) is an important adaptor protein in TLR3 and TLR4 signalling pathways that mediate proinflammatory cytokine and IFN responses …
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Immune Control of Hepatitis B Virus infection by innate lymphocytes
… people worldwide and despite the availability of a vaccine, it remains the second biggest carcinogen in the world and a serious global health problem. The majority of adult infections are resolved while 90% of neonates fail to clear infection. Persistently-infected individuals harbour a risk of …
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Exploring the molecular basis to the regulatory effects of Cannabinoids on toll-like receptor signalling
… innate immune responses, with dysregulation of TLR pathways associated in both autoimmune and inflammatory diseases. Numerous reports suggest that cannabinoids, known to exhibit general immunosuppressive properties, have potential therapeutic value in the treatment of inflammatory conditions. …
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A Delineation of Mesenchymal Stromal Cell Therapeutic Action in New Models of Acute and Chronic Graft versus Host Disease
The potent immune regulatory capacity of mesenchymal stromal cells (MSC) has been extensively characterised in terms of T cells, natural killer cells and dendritic cells suppression; however the ability of MSC to modulate B cell biology is not fully understood. This immune suppressive ability has …
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The Role of Mesenchymal Stromal Cells in Inflammation and Treatment of Pulmonary Fibrosis
The aim of this body of work was to determine the method of action of mesenchymal stromal cell immunomodulation, and their potential benefits in treating pulmonary fibrosis. This was achieved through a series of in vitro studies and an in vivo model of lung disease, namely, bleomycin induced …
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Defining the Physiological and Molecular Role of Pellino3 in TLR3 Signalling
Innate immunity utilises a series of pathogen associated molecular pattern receptors such as the Toll-like receptors (TLRs) to detect and respond to invading microorganisms. The different TLRs play a pivotal role in the first line of defence by recognising the type of pathogenic threat encountered …
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Investigating the Role of Pellin03 in TNF Signalling
… necrosis factor (TNF) is an important modulator of the innate immune system, responsible for the activation of immune cells as well as the removal of damaged cells. Aberrant TNF signalling can cause a number of pathologic conditions. TNF binding to TNF receptor 1 triggers the activation of …
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Characterisation of the immunomodulatory properties of human natural killer T cells
… natural killer (iNKT) cells are a small subset of innate cells which express an invariant T cell receptor and NK surface molecules and recognize glycolipid antigen presented by CD1. iNKT cells have shown potent anti-tumour properties when stimulated with the iNKT cell agonist …
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Stem Cell and Biological Interventions to treat Allergic Airway Disease
The aim of this work was to investigate immune modulation with a particular focus on airway inflammation and allergic pathogenesis. This was probed in a model of pathogen driven immunomodulation (B. pertussis), and two models of therapeutic intervention namely immunisation (attenuated B. pertussis, …