Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Insig1"”.
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Regulation of sterol regulatory element binding protein-1 in bovine mammary epithelial cells
… linoleic acid (CLA) on insulin induced gene-1 (Insig1), an endoplasmic reticulum (ER) protein that anchors SREBP1 and prevents proteolytic activation of SREBP1. MacT cells were treated with increasing levels of t10, c12-CLA. High concentration of t10, c12-CLA inhibited Insig1 degradation …
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Molecular and cellular aspects of the SREBP pathway
… identified SREBP1 interaction site(s) on SCAP. INSIG1 has a central role in regulating SREBP processing and in regulating stability of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), a rate limiting enzyme in cholesterol biosynthesis. There are two protein isoforms of human INSIG1 …
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Positionelle Klonierung von Tbc1d1 als Kandidatengen für Adipositas
… Expression: 2310045A20Rik, Tbc1d1, Ppp1cb, Mll5, Insig1, Abhd1 und Alox5ap. Die codierenden Bereiche dieser Gene wurden anschließend auf Sequenzunterschiede zwischen NZO und SJL untersucht. Nur im Gen Tbc1d1, das im Peak-Bereich des Nob1 lokalisiert ist, wurde eine SJL-spezifische Deletion von …
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Hedgehog Signaling Modulates Cholesterol Homeostasis in Chondrocytes and in Osteoarthritis
… were generated. This was achieved by excising Insig1 and Insig2, major negative regulators of cholesterol homeostasis. Over time, mice with chondrocyte-specific cholesterol accumulation exhibited impaired growth of the long bones. With aging or surgically induced joint instability, these mice …
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Regulation of milk fat synthesis by dietary fatty acids
… Potential roles of the TF ChREBP, PPARG, and INSIG1 were also established. A subsequent study aimed to establish whether these mechanisms operated in lactating dairy cows. Compared with un-infused controls and a t10c12 CLA negative control, post-ruminal infusion of butterfat which contains all …
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A systems biology approach to the pathogenesis and progression of Non-Alcoholic Fatty Liver Disease
… approaches. 4. Contribution of MBOAT7 and INSIG1 in NAFLD progression in mice and humans. This chapter provides a proof of concept of how transcriptomic studies can be reverse-translated into mice to study the contribution of the targets I identified in mechanisms of NASH progression. Here …
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Search for molecular and metabolic mechanisms contributing to impaired β-cell function
… activity and histone modifications on the genes Insig1, Lss, Peci, Idi1, Hmgcs1 and Casr were found to be altered in a manner consistent with gene expression. This suggests the involvement of epigenetic regulations. In conclusion, this thesis suggests that the coupling between glycolytic and …
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Effects of weaning age and maternal nutrition on gene expression of longissimus muscle of beef steers
… (CEBPA, ZFP423) and lipogenic (THRSP, SREBF1, INSIG1) activators, and several enzymes (FASN, SCD, ELOVL6, PCK1, DGAT2) that participate in the process of IMF increased gradually to a peak between 96 and 167 days on treatment. Steers in NW did not achieve similar expression levels even by 222 …
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PHYTOCHEMICAL AND SYNTHETIC INVESTIGATIONAL COMPOUNDS AS MODULATORS OF CYTOMETABOLIC AND CYTOSKELETAL DYNAMICS FOR PRE-CLINICAL TARGETING OF PROSTATE CANCER
… with lipid and glucose metabolism (SREBP1/2, INSIG1, FASN, PKM2, PPARα/γ, mTOR, MAF, PDK1, LDLR, and SRB1), induced ER stress by elevating key targets in ER stress signaling (CHOP, ATF4, GRP94, GRP58, GADD 34, and PGC1α), increased glucose uptake and glycolysis due to severe nutrient and …