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Showing 1 to 18 of 18 for “"Inositol phosphates"”.
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Synthesis, crystallography and biological activity of myo-inositol phosphates
The antioxidant property of myo-inositol hexakisphosphate is important in the prevention of hydroxyl radical formation which may allow it to act as a 'safe' carrier of iron within the cell. Here, the hypothesis that the recently discovered natural product, myo-inositol 1,2,3-trisphosphate …
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Digestion of inositol phosphates by dairy cows: Method development and application
Successful implementation of dietary P management strategies demand improved understanding of P digestion dynamics in ruminants and this is not possible without a reliable and accurate phytate (Pp) quantification method. The objective of the first study was to develop a robust, accurate, and …
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Localisation and function of phosphoinositide-specific phospholipase C in Sacchromyces cerevisiae
… PtdIns(4,5)P\(_2\) to generate two messengers, inositol (1,4,5) trisphosphate [Ins(1,4,5)P\(_3\)] and diacylglycerol (DAG). Ins(1,4,5)P\(_3\) is an important second messenger in animal cells. It releases calcium from intracellular stores by opening Ins(1,4,5)P\(_3\) receptors (InsP\(_3\)Rs) and …
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Molecular and Pharmacological Studies of Alpha1-AR Subtypes and their Signaling Pathways
… and aie-AR-mediated accumulation of total [JH]-inositol phosphates and compared the results to those of control oligomer and mediaalone treated cells. [JFI]-Prazosin saturation binding experiments indicated that the antisense oligomer reduced cxib-AR density in a time- and …
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Structural and biochemical studies of plant inositol phosphate kinases
Among inositol phosphates, inositol hexakisphosphate constitutes the main form of phosphorus storage in seeds and beans. However, the pathway(s) of inositol hexakisphosphatesynthesis, particularly in plants, remain incomplete. To further our understanding of these pathways, five inositol phosphate …
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Inositol Pyrophosphate Phosphatases as Key Enzymes to Understand and Manipulate Phosphate Sensing in Plants
… group of secondary messenger molecules, inositol pyrophosphates (PP-InsP). PP-InsPs and their precursors, inositol phosphates (InsPs), are important for plant abiotic stress responses, hormone signaling, and other stress responses. While PP-InsPs are critical for plant survival, much …
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Pharmacological and Molecular Characterisation of P2Y Receptors in Endothelial and Epithelial Cells
… this study. The dose dependent accumulation of inositol phosphates and cAMP response to potent P2Y11 agonists and RT-PCR studies confirmed the functional expression of both P2Y2 and P2Y11 receptors in ECV304 cells. Likewise, the dose dependent accumulation of inositol phosphates in response to …
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MYO1C Binds to PiP2 With High Affinity Through a Putative Ph Domain
… higher affinity to Ins(1,4,5)P3 as well as other inositol phosphates which may act as inhibitors to membrane binding in the cell. By sequence and secondary structure analysis, we identified this phosphatidylinositol binding site in the tail to be a putative pleckstrin homology (PH) domain. Point …
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The transduction of light signals controlling floral induction in Pharbitis nil
… decided to investigate whether the phosphatidylinositol cycle, which, via the key signalling component, l(l,4,5)P3, releases calcium from intracellular stores in animal cells, is involved in the transduction of light signals physiologically active in floral induction. In physiological studies, …
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Effects of diet on phosphorus digestion in dairy cattle
… carbohydrate (NFC) content on total P (TP) and inositol phosphates-P (IPs-P) digestion. Samples of feed, duodenal digesta and feces from a previously conducted study were analyzed for TP and IPs-P. In this study, eight lactating Holstein cows were fed diets containing either 60 or 35% forage and …
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Cloning and characterisation of gonadotropin-releasing hormone receptors from species in non-mammalian vertebrate classes : amphibia and osteichthyes
… clone showed a GnRH-dependent stimulation of inositol phosphates. No full-length clone for X/b.1 could be isolated using cDNA from several different tissues. A partially processed transcript was, however, amplified from sympathetic ganglia cDNA. These ganglia showed specific binding to a …
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ROLES OF INOSITOL DIPHOSPHATES IN DNA REPAIR AND EFFECTS OF ASPIRIN ANALOGUES ON OESOPHAGEAL CANCER
Inositol phosphates (IPs) are important signalling molecules with various biological roles in a cell. One such role it is often associated with is DNA repair. The DNA repair process following DNA insult is considered crucial for the genomic integrity and stability. Failure to perform this task will …
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Regulation Of Inositol Biosynthesis And Cellular Consequences Of Inositol Depletion: Implications For The Mechanism Of Action Of Valproate
<p>Inositol is a six-carbon cyclitol that is ubiquitous in biological systems. It is a precursor for the synthesis of numerous biologically important compounds, including inositol phosphates and phosphoinositides that are essential for cell function and viability. Inositol compounds play a role in …