Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Inositol Phosphate"”.
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Structural and biochemical studies of plant inositol phosphate kinases
Among inositol phosphates, inositol hexakisphosphate constitutes the main form of phosphorus storage in seeds and beans. However, the pathway(s) of inositol hexakisphosphatesynthesis, particularly in plants, remain incomplete. To further our understanding of these pathways, five inositol phosphate …
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Connections Between Inositol Phosphate Signaling and Energy Responses in Plants
… for survival. One mechanism for this is the inositol phosphate (InsP) signaling pathway. This work focuses on the role of InsP signaling in maintaining energy homeostasis in the plant. InsP signaling is connected to energy sensing in plants via a protein complex containing both the inositol …
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Regulating Inositol Biosynthesis in Plants: Myo-Inositol Phosphate Synthase and Myo-Inositol Monophosphatase
Inositol is important for normal growth and development in plants. The regulation of the inositol biosynthetic enzymes, <I>myo</I>-inositol phosphate synthase (MIPS) and <I>myo</I>-inositol monophosphatase (IMP) was investigated. The specific aims of this research were (1) to develop a tool to …
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The role of the chicken gonadotropin-releasing hormone receptor C-terminal tail in expression and coupling
… and gonadotropin-releasing hormone-induced inositol phosphate production. The loss of gonadotropin-releasing hormone binding by the cS320STOP-truncated mutant suggests that this receptor is possibly not expressed on the cell membrane, which might be due to improper receptor folding by …
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Biochemical Characterization of Arabidopsis Enzymes Involved in Inositol Pyrophosphate Biosynthesis
… cues. One such signaling pathway is called inositol phosphate signaling. This research dissertation focuses on the inositol phosphate signaling pathway in plants, with emphasis on elucidating how a new class of signaling molecules collectively referred to inositol pyrophosphates are …
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The effect of cis-5,8,11,14,17-eicosapentaenoic acid upon the contractile mechanisms linked to calcium influx and the mobilisation of intracellular calcium in aortic smooth muscle
… To resolve this it was shown that EPA increased inositol phosphate formation which, it is suggested, caused the release of calcium from an inositol phosphate-dependent internal binding site, possibly that of an intracellular membrane or superficial sarcoplasmic reticulum, producing the transient …
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Molecular Characterization of Inositol Monophosphatase Like Enzymes in Arabidopsis thaliana
myo-Inositol synthesis and catabolism are crucial in many multicellular eukaryotes for production of phosphatidylinositol and inositol phosphate signaling molecules. myo-inositol monophosphatase (IMP) is a major enzyme required for the synthesis of myo-inositol and breakdown of inositol …
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Identification and Characterization of Late Pathway Enzymes in Phytic Acid Biosynthesis in Glycine max
Phytic acid, also known as myo-inositol hexakisphosphate or Ins(1,2,3,4,5,6)P6, is the major storage form of phosphorus in plant seeds. Phytic acid is poorly digested by non-ruminant animals such as swine and poultry, and it chelates mineral cations including calcium, iron, zinc, and potassium, …
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Molecular and Genetic Analysis of the Role of Ku in Silencing and Telomere Function in Saccharomyces Cerevisiae
… Ku senescence at 37°C identified a role for inositol phosphate signaling in telomere length regulation.
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Pathway and protein engineering for improved glucaric acid production in Escherichia coli
… our lab in 2009. Two of the pathway enzymes, myo-inositol phosphate synthase (MIPS) and myoinositol oxygenase (MIOX), appear to control flux. This work addressed several limitations of these reactions. One approach was the relief of reactive oxygen species (ROS) to improve MIOX performance. MIOX …
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Localisation and function of phosphoinositide-specific phospholipase C in Sacchromyces cerevisiae
… PtdIns(4,5)P\(_2\) to generate two messengers, inositol (1,4,5) trisphosphate [Ins(1,4,5)P\(_3\)] and diacylglycerol (DAG). Ins(1,4,5)P\(_3\) is an important second messenger in animal cells. It releases calcium from intracellular stores by opening Ins(1,4,5)P\(_3\) receptors (InsP\(_3\)Rs) and …
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The structure and function of the human ghrelin receptor
… of constitutive activity, signalling through the inositol phosphate pathway in the absence of bound agonist. TMs III and VI have been reported to be central to the activation of Family A GPCRs, with interactions between the two helices stabilising the ground state. During activation conformational …
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The role of Ca²⁺ and cAMP in GnRH-stimulated LH release
… level of intracellular Ca²⁺ mobilization, or (3) inositol phosphate metabolism. However, forskolin was able to synergistically interact with secretagogues that increase the cytosolic Ca²⁺ concentration and activators of protein kinase C. This suggested that forskolin was interacting with GnRH at a …
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The Role of Arabidopsis thaliana P80 in Inositol Signaling
The myo-inositol signaling pathway in plants allows them to sense external environmental stimuli and respond to them. This signaling pathway depends on the dynamic levels of the second messenger, inositol(1,4,5)trisphosphate, which in turn is regulated by inositol polyphosphate 5-phosphatases …
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Gonadotropin releasing hormone in agnathans
… Lamprey GnRH-II was also shown to activate the inositol phosphate signaling system in COS-7 cells transiently transfected with the lamprey GnRH receptor. These studies provide evidence for a novel lamprey GnRH that has a role as a third hypothalamic GnRH. The newly discovered lamprey GnRH-II …
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HIV needs the small molecule IP6 to build its capsid
… shows that coordination of the small molecule inositol hexakisphosphate (IP6), which can bind to both the immature (via residues K158 and K227) and mature (R18 and K25) CA lattice is crucial. The data herein demonstrate the importance of these charged rings for viral replication and infection. …
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Molecular Characterization and Loss-of-Function Analysis of an Arabidopsis thaliana Gene Encoding a Phospholipid-Specific Inositol Polyphosphate 5-Phosphatase
The phosphatidylinositol signaling pathway utilizes inositol-containing second messengers to mediate signaling events. The enzymes that metabolize phosphoinositides can in some cases serve to terminate the signaling actions of phosphoinositides. The inositol polyphosphate 5-phosphatases (5PTases) …
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The Genetic Basis of Phytate, Oligosaccharide Content, and Emergence in Soybean
… to be due to a SNP mutation in its myo-inositol phosphate synthase (MIPS) gene located on LG B1. The third objective was to use the recombinant inbred population derived from CX1834 x V99-5089 to observe the combinations of all three mutations to see how the different alleles impact …
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Elucidating the function of inositol pyrophosphate signaling pathways in Arabidopsis thaliana
Phosphate (Pi) is an essential nutrient for plants, required for plant growth and seed viability. When Pi is limited, plants undergo dynamic morphological and metabolic changes to leverage available Pi, known as the Phosphate Starvation Response (PSR). The inositol phosphate (InsP) signaling …
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