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Showing 1 to 9 of 9 for “"Inositol 1,4,5-Trisphosphate Receptors"”.
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Control of Cardiac Hypertrophic Signaling by Inositol 1,4,5-Trisphosphate Receptors
… metabolism, gene expression, and cell death. The inositol 1,4,5-trisphosphate receptor (IP3R) is a calcium channel expressed in cardiac tissue. There are three IP3R isoforms encoded by separate genes. In the heart, the IP3R-2 isoform is reported to being most predominant with regards to expression …
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Dual regulation of inositol 1,4,5-trisphosphate receptors by inositol 1,4,5-trisphosphate and phosphatidylinositol 4,5-bisphosphate
… of a vast array of cellular processes. Inositol 1,4,5-trisphosphate receptors (IP<sub>3</sub>Rs) are key signal integrators, which transform extracellular stimuli into intracellular Ca<sup>2+</sup> signals. Only immobilised IP<sub>3</sub>Rs, licensed by association with KRas-induced …
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High-resolution optical analyses of inositol 1,4,5-trisphosphate receptors and the Ca²⁺ puffs they evoke
… Many intracellular Ca²⁺ signals are initiated by inositol 1,4,5-trisphosphate receptors (IP₃Rs) which respond to IP₃ produced when cell-surface receptors stimulate phospholipase C. IP₃Rs are regulated by both IP₃ and Ca²⁺, a property which allows Ca²⁺-induced Ca²⁺ release (CICR) between …
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Ratio-PCR to determine relative levels of expression of inositol 1,4,5-Trisphosphate receptors in rat tissues
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Camkii-Mediated Phosphorylation of the Inositol 1,4,5-Trisphosphate Receptor at Serine-150 Results in Decreased Channel Activity
… intracellular stores is via the activation of inositol 1,4,5-trisphosphate receptors (InsP3Rs) by the second messenger, inositol 1,4,5-trisphosphate (InsP3). InsP3 is produced when certain factors bind to G protein-coupled receptors on the plasma membrane, causing activation of phospholipase C …
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The Role of Calcium Signalling in Autophagy
… that prevented Ca<sup>2+</sup> release from inositol 1,4,5-trisphosphate receptors, inhibition of mitochondrial respiration, and knockdown of the mitochondrial Ca<sup>2+</sup> uniporter. The triggering of autophagy under these conditions was due to reduced cellular ATP levels. These data …
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Interactions between IP3 receptor and Kras-induced actin-interacting protein
Inositol 1,4,5-trisphosphate receptors (IP3R) function as intracellular channels, facilitating the release of Ca2+ from the endoplasmic reticulum (ER) upon IP3 binding. Before responding to IP3 in intact cells, IP3R must undergo a process called 'licensing,' involving the association with …
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High-resolution optical analyses of IP3-evoked Ca2+ signals
… many cellular responses. Most cells express inositol 1,4,5-trisphosphate receptors (IP3R) that mediate Ca2+ release from the endoplasmic reticulum (ER) when they bind IP3 produced after activation of cell-surface receptors. Vertebrate genomes encode three closely related subtypes of IP3R …
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Contributions of type 2 IP3 receptors to intercellular adhesions and invasion of glioblastoma cells
… messenger. Ca2+ signals are often initiated by inositol 1,4,5-trisphosphate receptors (IP3Rs), which mediate Ca2+ release from the endoplasmic reticulum. Mammals express three IP3R subtypes (IP3R1-3). I show that in glioblastoma cell lines, IP3R2 is the least abundant subtype (<5% of all IP3Rs), …