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Showing 1 to 13 of 13 for “"Inositol 1"”.
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Molecular characterization of XvlNO1, a myo-inositol 1-phosphate synthase gene from Xerophyta viscosa
Myo-inositol I-phosphate synthase (INO 1) catalyses the conversion of glucose-6-phosphate to myo-inositol I-phosphate, which is subsequently dephosphorylated to myo-inositol. Myo-inositol is a precursor for a number of important metabolites that include membrane components, storage molecules, …
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Isolation and Characterization of Soybean Genes Involved in Phytic Acid Metabolism: Phytase and 1-L-myo-Inositol-1-Phosphate Synthase
The objective of this research was to isolate and characterize soybean genes involved in phytic acid metabolism for use in genetic engineering strategies to improve phosphorus utilization. A soybean phytase from germinated cotyledons was purified 28,000-fold to apparent homogeneity and was …
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Biosensor-based strategies for improving pathway production in Escherichia coli
… to be limited by the two downstream enzymes myo-inositol-1-phosphate synthase (MIPS) and myo-inositol oxygenase (MIOX). This work develops and deploys a biosensor that recognizes a pathway intermediate in order to overcome both limitations. A biosensor for myo-inositol (MI) was developed using …
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Study of the Dynamics of Retaining GT-B Fold Glycosyltransferases Using Hydrogen Deuterium Exchange Mass Spectrometry
… GT-B fold. In the presence of acceptor substrate inositol-1-phosphate (I1P), decreaseddynamics occur in CgMshA's N-terminal domain (NTD) and linker regions. Conversely, withdonor substrate uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), dynamics decrease inboth domain halves. Identical …
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Molecular Characterization of Inositol Monophosphatase Like Enzymes in Arabidopsis thaliana
myo-Inositol synthesis and catabolism are crucial in many multicellular eukaryotes for production of phosphatidylinositol and inositol phosphate signaling molecules. myo-inositol monophosphatase (IMP) is a major enzyme required for the synthesis of myo-inositol and breakdown of inositol …
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Role of ryanodine receptors in neuronal calcium signalling and growth control
… 95 (PCB), ryanodine, caffeine, and that of the inositol-1 ,4 ,5-trisphosphate receptor (IP<sub>3</sub>R), bradykinin, effectively couple to the activation of Ca<sup>2+</sup> influx in these cells. The Ca<sup>2+</sup> influx signal due to these agonists can be inhibited by SOC blockers such as …
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Camkii-Mediated Phosphorylation of the Inositol 1,4,5-Trisphosphate Receptor at Serine-150 Results in Decreased Channel Activity
… intracellular stores is via the activation of inositol 1,4,5-trisphosphate receptors (InsP3Rs) by the second messenger, inositol 1,4,5-trisphosphate (InsP3). InsP3 is produced when certain factors bind to G protein-coupled receptors on the plasma membrane, causing activation of phospholipase C …
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The role of Ryanodine receptors in neuronal calcium signaling
… removal of Ca<sup>2+</sup> from the cells.</p><p>Inositol-1, 4, 5-trisphosphate receptors (IP<sub>3</sub>Rs) and ryandine receptors (RyRs) are the most studied Ca<sup>2+</sup> release channels located on the internal stores. Previous studies have shown ryanodine receptors (RyRs) play a key role in …
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Pharmacological regulators of T cell calcium stores
… aaptamine were cytotoxic at higher doses. The inositol 1 ,4,5 -trisphosphate receptor (IP<sub>3</sub>R) pathway was also found to be critically linked to T cell growth control. We observed that the IP3R modulator, 2- aminoethoxydiphenyl borate (2-APB) induced antigen-like Ca<sup>2+</sup> spike …
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Application of hydrogen deuterium exchange mass spectrometry in protein-ligand and protein-protein interactions
… (UDP-GlcNAc) and 1-L-myo-inositol-1-phosphate (I1P) can bind to CgMshA independently, but the I1P binding is not productive since it binds to an uncorrect site. Moreover, the I1P binding can lead to dynamic changes of CgMshA, while only UDP-GlcNAc can induce the major …
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An Analysis of the Role of Bacillus oleronius Proteins in the Pathogenesis of Ocular Rosacea
… resulted in neutrophil activation along the inositol 1, 4, 5-triphosphate (IP3) pathway with calcium (Ca2+) release, cytoskeletal rearrangement and conversion to filamentous (F)-actin, and increased chemotaxis. The effect of B. oleronius proteins on the secretion of monocyte-specific and …
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The transduction of light signals controlling floral induction in Pharbitis nil
… decided to investigate whether the phosphatidylinositol cycle, which, via the key signalling component, l(l,4,5)P3, releases calcium from intracellular stores in animal cells, is involved in the transduction of light signals physiologically active in floral induction. In physiological studies, …
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Induced Degradation of G-Protein-Coupled Receptors Through Proteolysis Targeting Chimeras
… we used a secondary messenger d-myo-inositol-1-phosphate (IP1) accumulation assay to measure the changes in activation of the Gaq signaling pathway with the addition of the HaloPROTAC3. We observed through these assays that the protein abundance and the signaling of each GPCR …