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Showing 1 to 20 of 237 for “"Inositol"”.
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Regulating Inositol Biosynthesis in Plants: Myo-Inositol Phosphate Synthase and Myo-Inositol Monophosphatase
Inositol is important for normal growth and development in plants. The regulation of the inositol biosynthetic enzymes, <I>myo</I>-inositol phosphate synthase (MIPS) and <I>myo</I>-inositol monophosphatase (IMP) was investigated. The specific aims of this research were (1) to develop a tool to …
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Biochemical Studies on Myo-Inositol
Made available in DSpace on 2014-12-05T19:37:02Z (GMT). No. of bitstreams: 1 5900548.pdf: 3497709 bytes, checksum: 6bef2131bd20b0781a92d9936db7fbf0 (MD5) Previous issue date: 1958
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Dual regulation of inositol 1,4,5-trisphosphate receptors by inositol 1,4,5-trisphosphate and phosphatidylinositol 4,5-bisphosphate
… of a vast array of cellular processes. Inositol 1,4,5-trisphosphate receptors (IP<sub>3</sub>Rs) are key signal integrators, which transform extracellular stimuli into intracellular Ca<sup>2+</sup> signals. Only immobilised IP<sub>3</sub>Rs, licensed by association with KRas-induced …
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Regulation Of Inositol Biosynthesis And Cellular Consequences Of Inositol Depletion: Implications For The Mechanism Of Action Of Valproate
<p>Inositol is a six-carbon cyclitol that is ubiquitous in biological systems. It is a precursor for the synthesis of numerous biologically important compounds, including inositol phosphates and phosphoinositides that are essential for cell function and viability. Inositol compounds play a role in …
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X-ray Crystallography of Inositol Dehydrogenase Enzymes
… iolG2. They have been putatively assigned as myo-inositol dehydrogenases by sequence comparison. The enzyme catalyzes the reversible conversion of myo-inositol to scyllo-inosose and the concurrent reduction of NAD+ to NADH. iolG1 was subsequently determined to be a myo-inositol dehydrogenase but …
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Structural and biochemical studies of plant inositol phosphate kinases
Among inositol phosphates, inositol hexakisphosphate constitutes the main form of phosphorus storage in seeds and beans. However, the pathway(s) of inositol hexakisphosphatesynthesis, particularly in plants, remain incomplete. To further our understanding of these pathways, five inositol phosphate …
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Synthesis, crystallography and biological activity of myo-inositol phosphates
The antioxidant property of myo-inositol hexakisphosphate is important in the prevention of hydroxyl radical formation which may allow it to act as a 'safe' carrier of iron within the cell. Here, the hypothesis that the recently discovered natural product, myo-inositol 1,2,3-trisphosphate …
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Towards biosensor-assisted directed evolution of myo-inositol oxygenase
… for this work was the directed evolution of myo-inositol oxygenase (MIOX), the enzyme that catalyzed the penultimate, rate-limiting step in the metabolic production of glucarate from glucose in E. coli. Here, we develop a biosensor that recognizes glucuronate, the direct product of MIOX, and …
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The Role of Arabidopsis thaliana P80 in Inositol Signaling
The myo-inositol signaling pathway in plants allows them to sense external environmental stimuli and respond to them. This signaling pathway depends on the dynamic levels of the second messenger, inositol(1,4,5)trisphosphate, which in turn is regulated by inositol polyphosphate 5-phosphatases …
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Control of Cardiac Hypertrophic Signaling by Inositol 1,4,5-Trisphosphate Receptors
… metabolism, gene expression, and cell death. The inositol 1,4,5-trisphosphate receptor (IP3R) is a calcium channel expressed in cardiac tissue. There are three IP3R isoforms encoded by separate genes. In the heart, the IP3R-2 isoform is reported to being most predominant with regards to expression …
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Molecular Characterization of Inositol Monophosphatase Like Enzymes in Arabidopsis thaliana
myo-Inositol synthesis and catabolism are crucial in many multicellular eukaryotes for production of phosphatidylinositol and inositol phosphate signaling molecules. myo-inositol monophosphatase (IMP) is a major enzyme required for the synthesis of myo-inositol and breakdown of inositol …
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Molecular Characterization of Two myo-Inositol Oxygenases in Arabidopsis thaliana
… One stress-responsive system involves myo-inositol (Ins). Ins is a precursor for cell wall components, inositol trisphosphate (Ins(1,4,5)P3) and phosphatidylinositol phosphate signaling molecules, and an alternate ascorbic acid (AsA) synthesis pathway. The enzyme, myo-inositol oxygenase …
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Biochemical Characterization of Arabidopsis Enzymes Involved in Inositol Pyrophosphate Biosynthesis
… cues. One such signaling pathway is called inositol phosphate signaling. This research dissertation focuses on the inositol phosphate signaling pathway in plants, with emphasis on elucidating how a new class of signaling molecules collectively referred to inositol pyrophosphates are …
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Connections Between Inositol Phosphate Signaling and Energy Responses in Plants
… for survival. One mechanism for this is the inositol phosphate (InsP) signaling pathway. This work focuses on the role of InsP signaling in maintaining energy homeostasis in the plant. InsP signaling is connected to energy sensing in plants via a protein complex containing both the inositol …
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