Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Inosine"”.
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Inosine-containing mRNA induces an innate immune response and is translated with lower efficiency
Inosine is a nucleoside formed by deamination of adenosine by adenosine deaminases acting on RNA (ADAR). ADAR editing activity is known to play a key role in modulating the host cell’s immune response to RNA. Here, we specifically study the effect of the presence of inosine in RNA by generating an …
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The Effect of Allopurinol and Inosine Administration on Xanthine Oxidoreductase Gene Expression, Mitochondrial Respiration, and Inflammation in Broiler Chickens
… oxiodreductase (XOR). In the first study, inosine, a purine precursor, was fed to 3 groups of 5 birds: Group 1 was fed 0 (control), Group 2, 0.6 mols inosine/kg feed (INO) and Group 3, INO treatment plus 50 mg allopurinol/kg BM (INOAL). Allopurinol is a known inhibitor of XOR and thereby …
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INVESTIGATION OF INOSINE AND HYPOXANTHINE AS BIOMARKERS OF CARDIAC ISCHEMIA IN PLASMA OF NON-TRAUMATIC CHEST PAIN PATIENTS AND A RAPID ANALYTICAL SYSTEM FOR ASSESSMENT
… detection method was developed and utilized for inosine, hypoxanthine and other adenosine triphosphate (ATP) catabolic by-products in Krebs-Henseleit (Krebs) buffer solution, with analysis on perfusate samples from isolated mouse hearts undergoing 20 min acute global ischemia. The HPLC-UV method …
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The Effects of 3-Phosphoglycerate and Other Metabolites on the Activation of AMP-Activated Protein Kinase by LKB1/STRAD/MO25
… carnitine (Carn), acetyl-carnitine (Acarn), inosine monophosphate (IMP), inosine, and ammonia for allosteric regulation. We found that 3PG stimulated LKB1-STRAD-MO25 activity and allowed for increased AMPK phosphorylation. 3PG did not stimulate LKB1-STRAD-MO25 activity toward the peptide …
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Identification of RNA editing in the human exome and development of DARNED DatabaseSF
… developed central nervous system is Adenosine to Inosine deamination. Inosine is recognized as Guanosine by the translational machinery and reverse-transcriptase. In primates, RNA editing occurs frequently in transcripts from repetitive regions of the genome. In humans, more than 500,000 editing …
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Purine Degradation and Ureide Catabolism by Soybean (Glycine Max (L.) Merrill); Cell Suspension Cultures
… acid, and their purine precursors uric acid and inosine-5$\sp\prime$-mono- phosphate (IMP), as sole nitrogen sources. The inhibitors of purine degradation, allantoxanamide and allopurinol, caused accumulation of uric acid and hypoxanthine, respectively, in cell suspensions fed radiolabelled IMP …
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Studies on the mechanism of action of thyroid hormones
Inosine monophosphate (IMP) is a precursor of the two purine nucleotides, adenosine monophosphate (AMP) and guanosine monophosphate (GMP)e through DEAE-Scphacex, and the reaction IMP~ XMP is catalyzed by: IMP dehydrogenase which was purified in a manner similar to adenylosuccinate synthetase. …
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The purification and characterization of phosphoenolpyruvate carboxykinase
… P-enolpyruvate carboxykinase catalyzes the inosine diphosphate- and Mn⁺⁺ - dependent carboxylation of 664 moles of phosphoenolpyruvate per min per mole of enzyme at pH 7.0 and the ITP- and Mn⁺⁺ - dependent decarboxylation of 4650 moles of oxalacetate per min per mole of enzyme at pH 7.5. The …
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Metabolism in Vascular Endothelial Cells: Effects of Hyperglycaemia, Pro-Inflammatory Cytokines and Polyphenols
… that of the resting cells and also increase inosine concentrations, which is in keeping with an anti-inflammatory action. Quercetin treatments alone were shown to reduce concentrations of the pro-inflammatory metabolites ATP and ADP and, in parallel, increase concentrations of the …
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Structural and functional insights to Bacillus spore germination and toxin engineering for sustainable agriculture
… GerQ GR in triggering a germination response to inosine in B. cereus spores, whereas GerQ appears to have an essential requirement for GerI to cooperatively enable more efficient spore germinative responses. Amino acid residues critical to the recognition of the inosine, alanine and sodium …
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Biomarkers identification in fibromyalgia syndrome
… considerably higher serum concentration of inosine, hypoxanthine and xanthine levels (p<0.001) and lower serum adenosine (p<0.05) were detected in the FMS patients when compared to healthy controls. Our data show a negative correlation between adenosine and the Fibromyalgia Impact …
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Chemoreceptors From the Hawk Moth Manduca Sexta L
… MsOr2, was discovered using fully degenerate inosine primers designed to conserved motifs of a unique group of highly conserved odorant receptors. Comparison of RT-PCR, quantitative real-time PCR and in situ hybridization results with those of previously described odorant receptors in the …
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Molecular analysis of GerP and spore-associated proteins of Bacillus cereus
… which are both shown to have an involvement in inosine mediated spore germination in this strain. However, hypothetical interactions between antiporter proteins and the ‘linker-like’ N-terminal domain of the GerIA inosine-responsive germinant receptor protein appear unlikely since spores …
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Screening for purine transporters in S. aureus
… and 6-mercaptopurine and supplementing inosine monophosphate and/or guanine as an exogenous purine source. I identified an ATP-Binding Cassette transporter mutant that failed to grow under the selective purine transport conditions. Further growth characterization of the mutant revealed …
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THE ROLE OF ADARS-INTERACTING RNA HELICASES IN SHAPING THE RNA EDITOME IN CANCER
Adenosine-to-inosine (A-to-I) RNA editing, primarily catalysed by the ADAR family of proteins, is oftentimes dysregulated in cancers. However, the regulatory mechanisms controlling editing frequency in cancer cells remain largely elusive. Besides factors affecting the expression and activity of …
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RNA EDITING INDEPENDENT FUNCTIONS OF ADENOSINE DEAMINASES ACTING ON DOUBLE-STRANDED RNA IN HEPATOCELLULAR CARCINOMA
… IS A FAMILY OF ENZYMES CATALYSING ADENOSINE TO INOSINE CONVERSION (A-TO-I EDITING). IF HAPPENED IN CODING REGIONS, A-TO-I EDITING CAN CAUSE PROTEIN RECODING. RECODING EDITING HAS BEEN REPORTED TO CONTRIBUTE TO HEPATOCELLULAR CARCINOMA (HCC) DEVELOPMENT. HOWEVER A-TO-I EDITING IS MOSTLY ENRICHED …
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Analisi Molecolare del Melanoma
… lines as compared with melanocytes: galectin-1, inosine-5'-monophosphate dehydrogenase 2, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A ¿ isoform, protein DJ-1, cyclophilin A and cofilin-1. We show, for the first time, that only specific isoforms of these molecules are …
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The Adar-Mavs Pathway Is A Critical Mediator of The Innate Immune System In Pancreatic Development and Cancer
… protein that deaminates adenosine (A) to inosine (I). A-to-I editing is an important post-transcriptional mechanism to prevent recognition of endogenous RNA by MDA5, a cytosolic RNA sensor. Activation of MDA5 by viral RNA can stimulate the innate immune system. Thus, ADAR-mediated RNA …
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Nutrient and Stress-Induced Mitochondrial Hyperfusion Regulates Cell Death Pathways
… response. Furthermore, enzymatic inhibition of inosine monophosphate dehydrogenase further blocked this hyperfusion response, indicating a key role of purine biosynthesis in mitochondrial remodelling. The functional role of mitochondrial hyperfusion has been linked to a pro-survival response and …
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Synthesis of 3'-deoxy- and 2',3'-dideoxy-4'-C-alkyl-D-nucleosides: potential antiviral agents
… cytidine, 5-fluorocytidine, adenine and inosine; as well as, 3'-deoxy- and 2' ,3'-dideoxy-5-methyl-4' -C-phenyluridine.
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