Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Innovative drug"”.
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Innovative drug delivery systems for colon targeting
… als die vielversprechensten für diese Art von innovativen Arzneiformen identifiziert werden: Nutriose FB 06 (ein verzweigtes Dextrin mit nicht verdaulichen Glycosidbindungen: α-1,2 und α-1,3), Lycoat RS 780 (eine pregelatinierte, modifizierte Stärke), Glucidex 1 (ein Maltodextrin), Eurylon 7 …
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LIPID-BASED APPROACHES TO OPTIMIZE THE EFFECTIVENESS OF INNOVATIVE DRUG MODULATORS IN CYSTIC FIBROSIS
… a cumulative effect of this lipid to the triple drug combination on CFTR correction at the PM. Understanding the CFTR interactome, including its interactions with lipids, is important for unraveling the molecular mechanisms of cystic fibrosis and may provide insights into possible therapeutic …
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Computational Modeling of Intracapillary Bacteria Transport in Tumor Microvasculature
The delivery of drugs into solid tumors is not trivial due to obstructions in the tumor microenvironment. Innovative drug delivery vehicles are currently being designed to overcome this challenge. In this research, computational fluid dynamics (CFD) simulations were used to evaluate the behavior of …
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The discovery identification and characteristion of antimicrobial peptides from amphibian frogs and scorpion venom
… and these have become attractive targets for innovative drug development. In Chapter 3, an antimicrobial peptide (Phylloseptin-PHa) from the phylloseptin family was employed to investigate the structure-activity relationship, and the balance of hydrophobicity and charge determines the …
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Drug delivery strategies to overcome ocular hypertension
… these limitations, this thesis explores two innovative drug delivery strategies using anti-glaucoma drug-rich nanoparticles, called colloidal drug aggregates (CDAs). The first strategy involves a periocular hydrogel-nanoparticle composite designed for sustained, local delivery to the eye. …
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Broad-spectrum antivirals against coronavirus using natural products and drug repurposing strategies
… product-based discovery and host-targeted drug repurposing. Chapter three investigates natural product-based antiviral discovery, with a focus on Nigella sativa (black seed) oils. While direct contact assays revealed limited antiviral efficacy, vapour-phase diffusion of the oils …
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Exosomes and miRNAs in disease pathogenesis and opportunities for molecular targeting
… molecular diagnostic approaches, as well as innovative drug delivery modalities for small RNA-targeted therapy. My research resulted in a) the establishment of new methods and approaches to the study of exosomes/EVs, as well as comparative literature on the efficacy of several isolation and …
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Non-Neuroleptic Antitubercular and Anticancer Therapeutics through Rational Drug Remodelling of Phenothiazines and Related Antipsychotics
In light of shrinking pharmaceutical drug pipelines and drug resistance, innovative drug discovery strategies are of imperative need. Drug repurposing and related strategies such as drug rescue and drug remodelling have garnered significant research interest. Various clinically approved …
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Novel formulations of a poorly soluble drug using the extrusion process.
… the pharmaceutical industry and academia as an innovative drug delivery technology. This novel technique has been shown to be a viable and robust method for preparing different drug delivery systems including pellets, implants, tablets, capsules and granules. The aim of this research was to …
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Design, synthesis, and biological evaluation of dihydronaphthalene and chalcone-based anticancer agents inspired by the natural product combretastatin A-4.
… of its corresponding water-soluble phosphate prodrug salt CA4P has inspired the development of a myriad of analogues and derivatives. Two dihydronaphthalene-based agents (KGP03 and KGP413) and their corresponding phosphate prodrug salts (KGP04 and KGP152), previously discovered by the Pinney …
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Accesso ai medicinali innovativi per indicazioni neurologiche in Europa: allineamento delle valutazioni di Health Technology Assessment tra i Paesi Europei
Anche per i prodotti approvati a livello centrale, ogni paese europeo è responsabile dell'accesso al mercato nazionale dopo l'approvazione dell'Agenzia europea dei medicinali (EMA). Questo iter può comportare disuguaglianze in termini di accesso, a causa di pareri discordanti sul valore …