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Showing 1 to 12 of 12 for “"Inner hair cell"”.
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Supra-Characteristic-Frequency Response in Gerbil Auditory Nerve Frequency Tuning Curves
… (BM), inside the cochlea and, in turn, leads to inner hair cell excitation and auditory nerve fiber (ANF) responses. The goal of this study is to better understand the mechanics of inner hair cell excitation which leads to hearing. BM motion and ANF tuning are generally very similar, but the ANF …
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Design and Characterization of Biomimetic Artificial Hair Cells in an Artificial Cochlear Environment
… characterization of a new biomimetic artificial inner hair cell sensor in an artificial cochlear environment. Designed to mimic the fluid flows around the inner hair cells of the human cochlea, the artificial cochlear environment produces controlled, linear sinusoidal fluid flows with frequencies …
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Precision and reliability of cochlear nerve response in mice lacking functional synaptic ribbons
… membrane of photoreceptors, retinal bipolar cells and hair cells. Ribbon synapses are characterized by sustained exocytosis that is graded with stimulus intensity and can achieve high release rates. Leading hypotheses implicate the ribbon in maintenance of a large readily releasable pool …
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Sound-induced micromechanical motions in an isolated cochlea preparation
… to play a role in cochlear mechanics, including inner and outer hair cell bundles, the tectorial membrane, inner and outer pillar cells, and efferent fibers in the tunnel of Corti. In some preparations, individual stereocilia of inner hair cell bundles can be resolved.
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Auditory model comparison and optimization using dynamic time warping
… selectivity, compression, and a limited set of inner hair cell dynamics. We apply these techniques to related work and seek to identify the model that best describes the transduction of both naturally produced and spectrally reduced synthetic stop consonants. We produce and compare optimized …
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Cochlear hair cell regeneration from neonatal mouse supporting cells
Unlike lower vertebrates, capable of spontaneous hair cell regeneration, mammals experience permanent sensorineural hearing loss following hair cell damage. Although low levels of hair cell regeneration have been demonstrated in the immature mammalian vestibular system, the cochlea has been thought …
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The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse
… governing transmitter release at the cochlear inner hair cell (IHC)-spinal neuron synaptic junction compared to those at higher synapses along the auditory pathways. We characterized functional properties of calyx synapses in wildtype (wt) compared to those developing in CaV1.3 …
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ORAL ADMINISTRATION OF EPIGALLOCATECHIN-3-GALLATE (EGCG) IS A POTENTIAL THERAPEUTIC FOR CISPLATIN-INDUCED HEARING LOSS
… hearing loss results from damage to outer hair cells (OHCs) in basal turn of the cochlea, to spiral ganglion neurons (SGN), stria vascularis (SV) and fibrocytes of spiral ligament (SL). At the cellular level, cisplatin produces profound increases in reactive oxygen species (ROS) that …
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Primary neuronal degeneration in the guinea pig effects on spontaneous rate-type
… are reversible and even if there is no hair cell loss. We hypothesized that this primary neural degeneration does not raise cochlear thresholds because it is selective for cochlear neurons with high thresholds and low spontaneous rates (SRs). We tested this hypothesis by recording from …
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Low-frequency bias-tone effects on auditory-nerve responses to clicks and tones : investigating multiple outer-hair-cell actions on auditory-nerve firing
Active motility in outer hair cells (OHCs) amplifies basilar-membrane (BM) and auditory-nerve (AN) responses to low-level sounds. The recent finding that medial olivocochlear (MOC) efferents (which innervate OHCs) inhibit AN initial peak (ANIP) responses from mid-to-high-level clicks, but do not …
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Molecular Physiology of the Ribbon Synapse
… Ca2+-Einstrom hervorgerufene Exocytose in den inneren Haarzellen (IHZ) der Cochlea ist ein kritischer Schritt für die Wahrnehmung von Geräuschen. In dieser Arbeit wurde mit Hilfe von knock-out-Mäusen die Regulierung von Ca2+-Kanälen in IHZ der Maus durch die CaV(beta)2 Ca2+-Kanaluntereinheit …
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Struktur und Funktion der afferenten Synapse innerer Haarzellen der Cochlea
… zu den Bändersynapsen zählende afferente Synapse innerer Haarzellen (IHZ) spielt bei der präzisen Codierung akustischer Reize in neuronale Signale im afferenten Hörnerven eine zentrale Rolle. In dieser kumulativen Dissertation werden anhand von zwei Publikationen (Meyer et al., Nature …