Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Innate signalling"”.
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Visualisation of innate immune signalling complexes in cells by cryo-electron tomography
Innate immune signalling is a vital immune response to various infections and cell damage. A common feature of innate signalling complexes is forming a signalling platform through oligomerisation in cells. RIG-I-like receptors (RLRs), RIG-I, MDA5 and LGP2 sense cytosolic viral dsRNA and then …
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DEVELOPMENT OF AN IN VIVO MULTITASKING BIOLUMINESCENT REPORTER GENE PLATFORM FOR THE PRECLINICAL EVALUATION OF RNA THERAPEUTICS
… cell-cycle regulation, and immunoregulatory signalling. Firstly, in vitro reporter-based screening platform was established to assess off-target effects of the allele-specific siRNA siRyR2-U10, developed for the treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT). Using …
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Investigating TLR-4 signalling in response to protein ligands
… 4 and four IRAK1/2 molecules. This triggers a signalling cascade which results in nuclear factor (NF)-κB transcription factor activation and production of pro-inflammatory effector molecules such as the cytokine Tumour Necrosis Factor (TNF)-α. Upon activation TLR-4 is also endocytosed where it …