Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Innate lymphocytes"”.
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Immune Control of Hepatitis B Virus infection by innate lymphocytes
… and effective therapies are required. Innate lymphocytes include NK, NT, NKT and T cells and comprise a group of MHC-unrestricted lymphocytes that can elicit potent cytokine production and cytotoxicity at a very early stage of virus infection. We proposed that a better understanding …
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The transcriptional programme of natural killer (NK) cell functional maturation and maintenance
… adaptive immune system but its function within innate lymphocytes has been unclear. The studies presented here show that BACH2 acts as an intrinsic negative regulator of NK cell maturation and function. BACH2 is expressed within developing and mature NK cells and promotes the maintenance of …
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Transcriptional Regulation of Clr-b (Clec2d) in Health and Disease
Innate immunity provides the first line of defense against infectious disease and cancer. Natural killer (NK) cells are innate lymphocytes that recognize and eliminate pathological cells. Target cell recognition is facilitated by germline-encoded NK cell receptors, including the NKR-P1B inhibitory …
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Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells
… towards natural killer T (NKT) cells of the innate immune system. Critical to the recognition of glycosylceramides by NKT cells are antigen presenting cells (APC), such as dendritic cells, which are responsible for binding, processing, and delivery of ligands to these lymphocytes. This event …
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Genetic Investigation of MHC-independent Missing-self Recognition by NK Cells
NK cells are innate lymphocytes involved in the elimination of transformed, infected, stressed, antibody-coated and transplanted cells. The goal of this thesis, as well as the interest of our laboratory is to explore the MHC-independent “missing-self” branch of NK recognition, and more …
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Investigating the role of innate lymphoid cells in targeted radiotherapy in lung cancer
… in lung cancer. In the lung, ILC2s are critical innate lymphocytes that modulate Type 2 immunopathology, but their role in modulating the immune response to lung cancer is not fully understood. Furthermore, it is unclear how ILC2s respond to targeted lung radiotherapy. In this thesis, I …
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Exploring the role and the function of Aryl Hydrocarbon Receptor (AhR) and Aryl Hydrocarbon Nuclear Translocator (ARNT) in T cells
… a mouse model that would fate mark single lymphocytes that have activated AhR signaling pathways. A third strategy was to examine the impact of deletion of AhR and ARNT on CD8 T-cell function. <br/>The data show that AhR and ARNT expression in CD8 T cells is limited to immune activated …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
T lymphocytes are critical components of an effective adaptive immune response, with different subsets performing proinflammatory and immuno-suppressive roles. In response to foreign antigens, naïve T cells activate expand and differentiate into effector T cells which mediate pathogen elimination. …