Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 361 for “"Innate immunity"”.
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Regulatory Mechanisms in Innate Immunity
Innate immunity is the frontline for the host to defend against infections. This process entails the cooperation among pathogen recognition receptors, adaptor proteins, kinases, and transcription factors that elicit the production of effector cytokines. As an important transcription factor, IRF5 …
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Human Cellular Genetics of Innate Immunity
… type I interferon response is a key part of the innate immune system, responding to infection and inducing an antiviral intracellular state. While there is known to be variability in this signalling pathway between individuals, alongside cell-to-cell heterogeneity in a genetically identical cell …
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Adipocytes and Innate Immunity In Systemic Sclerosis
<p>Systemic sclerosis (SSc; scleroderma) is a chronic systemic autoimmune and connective tissue disorder characterized by vasculopathy, autoimmune phenomena, and widespread fibrosis. Skin thickening and tightening is the cardinal feature of SSc and is responsible, in part, for the considerable …
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Ribonuclease H2, RNA:DNA hybrids and innate immunity
The activation of the innate immune system is the first line of host defence against infection. Nucleic acids can potently stimulate this response and trigger a series of signalling cascades leading to cytokine production and the establishment of an inflammatory state. Mutations in genes encoding …
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The Role of LIFR Signaling in Innate Immunity
… are an abundant and key population in the innate immune response that originates in the BM, and they circulate to monitor the periphery. Monocytes are composed of many subsets that have essential and specific functions, including swift egress from the BM, production of pro-inflammatory …
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Activation of innate immunity during systemic Candida infections
Contains fulltext : 144023.pdf (Publisher’s version ) (Open Access)
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Salmonella Suppress Innate Immunity by Targeting Mast Cells
… at the host-environment interface and their innate capacity to rapidly release modulators of immune cell trafficking which promotes the early recruitment of pathogen-clearing immune cells from the blood. However, host-adapted pathogens had been a critical threat to human for a long time …
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Genetic analysis of innate immunity in Caenorhabditis elegans
… Caenorhabditis elegans is a model for studying innate immunity. Several conserved activators in the p38 PMK-1 pathway have been identified and are required for pathogen resistance to the bacterium Pseudomonas aeroginosa. Thus far, screens have been performed to identify mutants that are …
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Innate immunity in Zika Virus infection and neurogenesis deficits
… to ZIKV. Microglia are the first and major innate immune defenders of the brain. They arise exclusively from the progenitor cells in the embryonic yolk sac (YS) and migrate to the fetal brain during a restricted time window. Microglia from the brain are able to transmit the virus to NS/PCs …
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Regulation of DHX16-mediated Innate Immunity by Unanchored Polyubiquitin
The innate immune system recognizes pathogens via unique signals present in the invading organism upon infection known as pathogen-associated molecular patterns (PAMPs). Recognition of PAMPs during viral infection requires host molecules capable of interpreting these foreign signals called pattern …
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Potential Roles of Peroxidases In Caenorhabditis Elegans Innate Immunity
… ROS serve as direct and indirect effectors of innate and adaptive immunity. In <em>Caenorhabditis elegans</em>, a ROS burst is observed during infection and is mediated by the dual oxidase BLI-3, which produces H<sub>2</sub>O<sub>2</sub>. RNAi (RNA interference) to reduce the amount of BLI-3 …
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Mucosal Barrier Injury, Innate Immunity, and Stem Cell Transplantation
Contains fulltext : 87189.pdf (Publisher’s version ) (Open Access)
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INNATE IMMUNITY IN ENCEPHALITIC BUNYAVIRUS INFECTION: OVERCOMING NEURONAL VULNERABILITY
… infect neurons due to dampened neuronal innate immune responses. Innate immunity, including the antiviral interferon (IFN) and inflammatory NF-κB pathways, coordinates host responses to pathogens. It is unclear whether neurons are able to detect RVFV and LACV and mount an effective …
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Evasion Of Innate Immunity By The Pathogen Coxiella Burnetii
… interactions is displayed by studies on the innate immune system, which is on a constant evolutionary arms race with invading microbes. In this dissertation, we explore the innate immune response to the bacterial pathogen Coxiella burnetii. This intracellular pathogen has an intimate …
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Epidermal Reactions to Injury with Implications for Innate Immunity
… left vulnerable to microbial invasion. Inducible innate immune response mechanisms exist to keep the wound site free from infection, thus allowing the wound to heal and the epidermis to re-establish its barrier function. The main focus of the present thesis has been to investigate the regulatory …
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Dynamic Programming of Innate Immunity in Health and Disease
Whether innate immune cells may be adapted into potential memory states has becoming an important question in the field of immunity. Although previous conceptual paradigm failed to acknowledge this important question, emerging clinical and basic observations have started to shed intriguing clues to …
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Dissecting the Novel Roles of TRIM56 in Antiviral Innate Immunity
… with several demonstrating roles in regulating innate antiviral responses. Of >70 known TRIMs, TRIM56 inhibits replication of bovine viral diarrhea virus, a ruminant pestivirus of the family <em>Flaviviridae</em>, but has no appreciable effect on VSV, a rhabdovirus. We have also shown that …
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Characterizing the Innate Immunity in the Hawaiian Coral Montipora capitata
… stressors, including disease. Corals possess innate immune responses that aid in protection against these stressors. In several coral species, immune responses are inducible in response to stress. Montipora capitata is a predominant coral in Kaneohe Bay, Oahu, Hawaii. This coral occurs in two …
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Genes and mechanisms in Arabidopsis innate immunity against Leptosphaeria maculans
Leptosphaeria maculans is a hemibiotrophic ascomycete that causes blackleg disease on Brassica oilcrops, which globally is a great threat for oilseed production. In order to obtain mechanistic understanding of this devastating pathogen, Arabidopsis thaliana was used as a model host. Susceptible …
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Gene expression and signaling in Rxo1 governed innate immunity in cereals
Many maize lines carry Rxo1, an NB-LRR gene that confers a rapid hypersensitive response (HR) after infiltration with the rice streak pathogen Xanthomonas oryzae pv. oryzicola (Xoc) or the maize stripe pathogen Burkholderia andropogonis (Ba) carrying the effector genes avrRxo1 or avrRba1 …
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