Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 211 for “"Innate immune system"”.
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Senescence and the Innate Immune System
… function. Senescent cells are removed by the innate immune system, including natural killer (NK) cells, during normal embryonic development and healthy wound healing. Since eradication of senescent cells in mice leads to resistance against age-related disorders and functional restoration, one …
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Exploring the role of Leucine Rich Repeat Kinase 2 within the innate immune system
… and cell types, including neuronal tissue and innate immune cells. Mutations in LRRK2 have been linked to inflammatory diseases, most notably Crohn’s disease and Parkinson’s disease. Further to this, LRRK2 expression is induced by innate immune stimuli, and can be phosphorylated by Myd88 …
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Effect of aging and lifelong exercise on the innate immune system in human skeletal muscle
Access to abstract permanently restricted to Ball State community only.
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Obesity as a Risk Factor for Preeclampsia: Role of Inflammation and the Innate Immune System
… by mechanisms involving inflammation and the innate immune system. First, we used immunohistochemical studies to identify neutrophil infiltration, NF-κB activation and COX-2 expression in vascular tissue of obese women. We then demonstrated similar neutrophil infiltration and vascular …
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Characterization of the role of the innate immune system in the pathogenesis of chikungunya virus in mice
… and to aid in elucidating the role of the immune system in CHIKV pathogenesis. Infecting young outbred mice resulted in an acute illness with severe myositis and inflammation in the skeletal muscle. This was used as a small animal model that aided in the study of the pathogenesis and the …
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Defining the role of the transcription factor T-bet in the innate immune system in intestinal inflammation.
… lacking the transcription factor T-bet in the innate immune system (Tbx21-/- x Rag2-/- Ulcerative Colitis, or TRUC) develop microbiota-dependent inflammatory bowel disease (IBD). The innate immune mechanisms responsible for causing disease are still to be resolved, yet potentially offer novel …
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Mycobacterium tuberculosis and trypanosoma brucei as models for the TLR-dependent activation of the innate immune system
Includes bibliographical references.
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The Adar-Mavs Pathway Is A Critical Mediator of The Innate Immune System In Pancreatic Development and Cancer
… of MDA5 by viral RNA can stimulate the innate immune system. Thus, ADAR-mediated RNA editing is crucial to distinguish “self” from “non-self”. ADAR has an important role in gene regulation as A-to-I editing alters RNA processing affecting both RNA and protein abundance. Given its …
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Investigating the effect of yeast and mineral dietary supplements during the periparturient period on the production, physical health, and innate immune system of dairy cows
… cow disorders that result from compromised immune function and a lack of metabolite availability. Different dietary strategies through ration formulation or supplementing feed additives have been employed to mitigate these negative effects. The objectives of this dissertation were to: 1) …
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Neutrophil Responses to Mixed-Species Anaerobic Biofilms
… infections and chronic inflammation. Host immune cells have difficulties in clearing biofilm-related infections and this can result in unnecessary tissue damage due to the overproduction of proinflammatory mediators. The objective of this project was to generate mixed-species anaerobic …
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The Modulation of Innate Immunity by Cellular and Viral Noncoding RNAs
… non-coding RNAs possess the ability to alter innate immunity and inflammatory responses. For example, endogenous non-coding RNAs can be recognized by pattern recognition receptors to trigger innate immune activation and inflammation. Many positive sense RNA viruses also produce non-coding …
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Disruption of Dna Polymerase Zeta Promotes An Innate Immune Response
… that loss of pol ζ promotes activation of an innate immune response.</p> <p><em>Rev3l </em>knockout MEFs had over 1000 genes that were either upregulated or downregulated more than 4-fold. Importantly, this revealed that loss of <em>Rev3l</em>induced an increase in expression of known …
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TREX1 C-Terminus Regulates Oligosaccharyltransfererase to Prevent the Accumulation of an Endogenous Bioactive Disaccharide Associated with Autoimmune Disorders
The innate immune system is the first line of defense against infectious pathogens and serves a vital role in activating the adaptive immune system. Detection of viral and bacterial intracellular DNA by cytosolic DNA sensors (CDS) is crucial for the activation of the innate immune system and for …
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Novel innate immune functions of saliva
The innate immune system in humans has succeeded in developing numerous mechanisms against the injurious effects of bacteria, along with their toxins as a result of several thousand years of co-evolution. The oral mucosal surface represents such a unique environment, where despite being constantly …
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Development of a Novel Vaccine Adjuvant and Delivery System for Cancer and Influenza
… the potency and longevity of antigen specific immune responses. At present, there is a scarcity of safe vaccine adjuvants and delivery systems that can stimulate both cellular (Th1) and humoral (Th2) immune response. Such adjuvants are required for prevention or treatment of diseases like …
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COMPARISON OF E. COLI AND Y. PESTIS LPS TLR4 TIME COURSE ON P388D1 MACROPHAGES USING FLUORESCENT CONJUGATED ANTIBODIES
The innate immune system enables cellular response to infectious agents, and protein interactions are essential for this response. However, the protein interactions involved in cellular response to pathogens are not completely understood. Clarifying the manner in which proteins bind and respond to …
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Host modulation of excessive innate immune responses
A fundamental role of the innate immune system is to elicit a proper response against both invading pathogens and tissue damage or danger signals. Although the innate immune system often is successful in eliminating danger, an excessive host-response can result in severe tissue injury. Factors that …
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Psychoneuroimmune Implications of Non-Infectious Neuroimmune System Activation and the Impact of Type 2 Diabetes
… of infection, this brain-based response to innate immune system activation reflects a shift in an organism's motivational priorities to maximize immune efficiency in clearing the invading pathogen and facilitating recovery. However, in disease states that contain an element of chronic …
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Cellular Immune Changes in the Peripheral Blood of Subjects Chronically Infected with XMRV
… chronically alter the regulation of the innate immune system causing immunosuppression. Recently, evidence of a new human retrovirus, Xenotropic murine leukemia virus-related virus, XMRV, was detected in the blood of >67% of 101 Chronic Fatigue Syndrome (CFS) patients tested and shown to …
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