Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Innate immune sensors"”.
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Leveraging Innate Immune Sensors to Generate Durable Anti-Glioma Adaptive Immune Responses
… T cell effector infiltration but is dominated by immune suppressive microglia, macrophages, and myeloid-derived suppresser cells. These innate immune cells display impaired phagocytosis and antigen presentation and are inadequate for triggering the subsequent immune activating signals needed for …
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Understanding the Host Cellular Response to Astrovirus Infection
… and to protect viral RNAs from detection by innate immune sensors. In these studies, we provide the first evidence that astrovirus exploits some, but not all autophagy machinery to assist in viral replication at DMVs. Astrovirus replication and DMV formation relies upon induction of PI3KC3 …
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Induction and Regulation of CXCL10 in Hepatocytes During Hepatitis C Virus Infection
… liver disease, this work sought to evaluate how innate immune sensors of HCV infection (Toll-like receptor 3 [TLR3] and retinoic acid inducible gene I [RIG-I]) contribute to CXCL10 induction in hepatocytes. CXCL10 mRNA and protein were measured in primary human hepatocytes (PHH) and hepatocyte …
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Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection
<p>Pattern recognition receptors are innate immune sensors that recognize pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) with crucial roles in host defense against microbial infection, autoimmune diseases and cancer. Cytosolic nucleic acids including …