Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 85 for “"Innate immune cells"”.
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Immunomodulatory effects exerted by Lactobacillus salivarius strains on innate immune cells
… health status of their consumers. Modulation of immune responses is a plausible mechanism underlying these beneficial effects. The aim of this thesis was to investigate the effect of 33 Lactobacillus salivarius strains on the production of inflammatory cytokines from a variety of human and mouse …
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Innate Immune Cells may be Involved in Prepubertal Bovine Mammary Development
… In mice, this process is impacted by presence of innate immune cells. Whether or not such immune cells are present or involved in bovine mammary development is unknown. We studied the presence, location and changes in numbers of eosinophils, mast cells and macrophages in pre-pubertal bovine …
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HIGH-THROUGHPUT PROFILING OF INNATE IMMUNE CELLS TO UNVEIL TUMOR ESCAPE MECHANISMS IN MATCHED COLORECTAL CANCER AND LIVER METASTASES
… tumor types largely unresponsive to immune checkpoint (IC) therapies. Indeed, MSS/MSI-L tumors display "immune cold" microenvironments dominated by immunosuppressive mechanisms, which severely constrain treatment options. This unmet clinical need highlights the importance of …
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Imaging innate immune cell behaviour in lymphoid organs
Innate immune cells generate the early host response to infection and tissue injury. Neutrophils are rapidly recruited from circulation to inflammatory tissues for pathogen killing. Type 2 innate lymphoid cells (ILC2s) mediate early responses to helminths and allergens via cytokine production. …
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Neutrophil localization during C. rodentium-induced colitis
… such as the mucus layer, intestinal epithelial cells, and innate immune cells. Neutrophils are innate immune cells that are well recognized as first responders during infections, and they are armed with granules that contain toxic agents such as reactive oxygen species, proteases, and …
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Elevated temperature alters cytokine output and c-Jun N-terminal kinase signaling downstream of toll-like receptor activation
… in temperature can alter the phenotype of innate immune cells, such as phagocytic ability, but the effects of elevated temperature on the molecular mechanisms that underlie these differences remain poorly understood. Here, we describe alterations in cytokine production following stimulation …
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Recruitment and positioning of regulatory T cells and Th17/Tc17 in inflamed human liver
… in the normal and inflamed liver along with innate immune cells. The balance between these two subsets of lymphocyte is crucial in maintaining immune homeostasis by adjusting either hepatic tolerance or mounting immunity against invading pathogens. Thus, it is important to understand the …
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Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy
… the IAPs results in the sensitization of cancer cells to apoptosis in the presence of death ligands, such as tumour necrosis factor alpha (TNFα). I hypothesize that type I interferon (IFN) stimulation in cancer cells and in immune cells leads to the production of TNFα, which can then synergize …
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Defining interactions between Mycobacterium leprae and Langerhans cells
… knowledge of the intricate interactions with innate immune cells has made advances in some cell subsets but is limited in others leaving an incomplete picture of the disease. These gaps limit advances in disease management. M. leprae is an obligate, intracellular pathogen that grows …
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Exploring the role of Leucine Rich Repeat Kinase 2 within the innate immune system
… and cell types, including neuronal tissue and innate immune cells. Mutations in LRRK2 have been linked to inflammatory diseases, most notably Crohn’s disease and Parkinson’s disease. Further to this, LRRK2 expression is induced by innate immune stimuli, and can be phosphorylated by Myd88 …
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Sulforaphane as a potential nutritional intervention to reduce neuroinflammation associated with aging and sickness behavior
Innate immune cells provide critical protection against pathogens and produce immune factors that drive adaptive sickness behaviors to facilitate recovery from acute illness and injury. Microglia, the resident innate immune cells in brain, recognize pathogens and danger associated molecular …
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Optimization of an Immune Assay to Detect Binding of NOD2 to Staphylococcus Aureus
… <em>S. aureus</em> has evolved ways to escape innate immune responses in the host, the mechanisms are not fully understood. One area of active research involves mechanisms by which <em>S. aureus</em> avoids detection by Pattern Recognition Receptors (PRRs), such as Nuclear Oligomerization …
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Macrophage-hitchhiking Anisotropic Microparticles for Therapeutic and Diagnostic Applications
… previously incurable diseases. A variety of cells have been applied for cell therapies, including stem cells, tissue-specific cells, and hematopoietic cells. Particularly, immune cells, a subset of blood cells, have gained significant attention owing to their inflammation-homing ability as …
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Role of Neuraminidase-mediated Desialylation in Microglial Activation
Microglia are the innate immune cells of the central nervous system (CNS) and play key roles in mediating the removal of dead or dying neurons, neurotoxic aggregates or neuronal debris, thus contributing to CNS health. Research in the recent years however has linked microglial activity to …
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The effects of calorie restriction and aging on natural killer cells in c57bl/6 mice
… even though it may be detrimental to the innate immune response. This research focuses on natural killer (NK) cells in aged (22 mo) calorie restricted (CR) C57Bl/6 mice. NK cells are innate immune cells capable of killing tumor or virus-infected cells. We used flow cytometry to analyze NK …
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Establishing in vitro models of neuroinflammation to investigate neuroimmune responses in neurocysticercosis
… disease remain grossly understudied, and how innate immune cells respond to this infection is still debated. One of the reasons for this is that there is a lack of reliable experimental models of inflammation at the level of the brain that allow for cell-type specific tracking of inflammation …
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Heterogeneity, Origins, and Role of Omental Macrophages in Health and Early Tumor Seeding
The host immune system is essential to maintaining tissue homeostasis and clearing pathogens. Tissue-resident macrophages (TRM) are innate immune cells that first appear at primitive hematopoiesis to facilitate fetal organ growth. After birth and depending on environmental cues, monocytes may …
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Super Low Dose Endotoxin Exacerbates Low Grade Inflammation through Modulating Cell Stress and Decreasing Cellular Homeostatic Protein Expression
… that SLD endotoxin may potentiate non-resolving innate immune cell inflammation through disrupting cellular endoplasmic reticulum (ER) homeostasis. We chose to study the dynamics of ER homeostasis in macrophages stimulated with SLD endotoxin. In naïve cells, ER stressor such as tunicamycin (TM) …
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Doxorubicin-Induced Cardiotoxicity Is Mediated By Neutrophils Through Release of Neutrophil Elastase
… is the contribution of inflammation and innate immune cells, in particular neutrophils. Recognizing that neutrophils have been implicated in a number of heart diseases, we evaluated the role of neutrophils in Dox-induced cardiotoxicity. Here, using echocardiography, flow cytometry and …
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TLR3 Signaling in Human BDCA-3 Dendritic Cells Results in the Formation of Several ILT3 and ILT4 Populations
<p>Dendritic cells (DCs) represent a population of innate immune cells that are highly efficient at promoting immune responses. DCs are capable of presenting antigens to both CD4 and CD8 T cells. DC presentation and interaction with T cells can result in either immune stimulation or tolerance. This …
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