Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Innate Immunology"”.
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The Role of HOIL 1 Ubiquitin Ligase Activity in MDA5 Antiviral Signaling
… RIG-I-like receptors (RLRs), RIG-I and MDA5, are innate sensors of RNA virus infections that are critical for mounting a robust immune response. RIG-I and MDA5 both signal to MAVS to induce antiviral cytokine induction but respond to different viruses and are activated by distinct mechanisms. The …
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Identification and characterisation of Group 3 Innate Lymphoid Cells in the renal tract
Innate lymphoid cells (ILCs) bear similarities to T-helper (Th) cells, but lack T cell receptors. The three groups mirror the effector functions of Th1, Th2 and Th17 cells and share the same transcription factors and cytokine profiles. This project focussed on type 3 ILCs (ILC3s) found primarily at …
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Effect of Advanced Age on the Innate Immune Response to Cutaneous Wound Infection
… adaptive immune response. Specific innate immune deficits have been tied to an elevated risk of S. aureus wound infection, including decreased neutrophil counts and function, reduced expression of cutaneous antimicrobial peptides and aberrant toll-like receptor 2 (TLR2)</p> …
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Genotypic and Molecular Determinants in the Continued Evolution of West Nile Virus in the United States
… and domain-dependent dysregulation of host innate antiviral responses. Overall, the studies in this dissertation support continued evolution of WNV with evidence of genetic and phenotypic changes over time.
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Alternative Carbon Utilization As A Virulence Determinant For Candida Albicans
<p><em>Candida albicans </em>is a polymorphic unicellular fungus that has evolved to proficiently colonize and infect mammals. A common constituent of the microbiome in the GI tract, mouth, vagina, and skin, <em>C. albicans </em>is also an opportunistic pathogen capable of causing a variety of …
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Innate Immunity in Chickens: In Vivo Responses to Different Pathogen Associated Molecular Patterns
… PAMP recognition by and stimulation of the innate immune system is crucial to an individual’s ability to quickly limit microbial growth and stimulate the adaptive immune system. Characterization of the in vivo immune responses initiated by PAMPs has not been directly addressed. Using growing …
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Investigations into the vaccinia virus immunomodulatory proteins C4 and C16
Vaccinia virus (VACV) is the most intensively studied orthopoxvirus and acts as an excellent model to investigate host-pathogen interactions. VACV encodes about 200 proteins, many of which modulate the immune response. This study focusses on two of these: C16 and C4, that share 43.7 % amino acid …