Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Ink4A/ARF"”.
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THE ROLE OF DMP1 IN HUMAN BREAST CANCER PROGNOSIS AND CYCLIN D1-INDUCED BREAST CANCER
… factor that directly binds and activates the Arf promoter. It is also a bona fide tumor suppressor that is activated by oncogenic Ras and HER2 signalings and in turn stimulates the Arf-p53 tumor suppression pathway. Dmp1 physically interacts with cyclin D1 that is frequently overexpressed in …
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Differential effects of epidermal growth factor receptor inhibitors on glioblastoma multiforme
… is the loss of crucial tumor suppressor genes Ink4A/ARF and PTEN, which contribute to the invasive nature and unregulated proliferation that underlie the GBM pathology. The high rate of tumor recurrence post treatment with surgical resection, chemotherapy, and radiation has driven the pursuit …
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BMI1 is a context-dependent tumor suppressor that is a barrier to dedifferentiation in non-small cell lung adenocarcinoma
… capacity primarily through silencing of the Ink4a/Arf locus. Bmi1 has been proposed as a good therapeutic candidate in cancer because of its presumed role in maintaining tumor propagating cells (TPCs). This conclusion is based on the observed tumor suppressive effects of Bmi1 deletion in in …
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Defining the functions of a conserved hydrophobic domain in the ARF tumor suppressor
The INK4A-ARF locus encodes two tumor suppressors; p16 and p19Arf, both of which restrain cell growth by regulating the functions of Retinoblastoma (Rb) and p53 respectively. Throughout development, p19Arf is kept at minimal levels, but under conditions of oncogenic stress, p19Arf expression is …
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E2F6 in axial skeletal development and gliosis
… Bmi 1 also represses transcription of the Ink4a-Arf locus, and it is consequently required to maintain the proliferative and self-renewal properties of hematopoietic and neural stem cells. However, E2F6 does not participate in the repression of the Ink4a-Arflocus. These findings underscore …
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Dissecting Molecular Mechanisms of Radioresistance Using in Vitro and in Vivo Brain Tumor Model Systems
… amplification/activation, PTEN loss, p53 loss, Ink4a/Arf loss). How these genetic changes may modulate responses to radiation and chemotherapy is not well understood. To elucidate this relationship, genetically defined mouse models have been used for both in vitro and in vivo analysis. Work has …
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Tissue-specific interactions between oncogenic K-ras and the p19A̳r̳f̳_p53 pathway determine susceptibility to transformation
… Ras to induce the tumor suppressive p1 9 Arf-p5.3 pathway and cause irreversible cell cycle arrest typifies this phenomenon. Using this-well established interaction as model, we investigated the cell-type specificity of oncogene-induced tumor suppression. By combining K-rasL mice with a …