Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Inhibitory Receptor"”.
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Role Of Il-27 And Tcr Stimulation In Inhibitory Receptor Expression
… on the ability of IL-27 to promote expression of inhibitory receptors on T cells. The studies presented here establish that TCR and cytokines have distinct and complementary roles in promoting inhibitory receptor expression. In vitro, IL-27, type I IFN, and IFN-g induced expression of PD-L1 and …
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Studies on the Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway in T Lymphocytes
… a delicate balance between stimulatory and inhibitory mechanisms is essential for the proper functioning of the immune system. Immuno-receptor Tyrosine-based Inhibitory Motif (ITIM)-bearing receptors in immune cells, including T lymphocytes, play a major role in preventing autoimmune …
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Influence of Anti-CD44 on Murine B Cell Activation
… prominent. Soluble anti-CD44 had no effect. The inhibitory effect of RK3G9 was not influenced by addition of anti-FCγRII, indicating no role for the inhibitory receptor. The effects of delayed addition of immobilized anti-CD44 mAbs were studied, and the results indicated no inhibition after 96 …
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Delineating the Role of CD244 in NK Cell Cytotoxicity and the Contribution of Ly108 to Thymocyte Development
… implicated polymorphisms in the SLAM family of receptors (CD244 (2B4), CD229 (Ly9), CS-1 (CRACC), CD48 CD150 (SLAM), CD84, and Ly108 (NTB-A)) as causative for a breach in tolerance of both T and B cells leading to the production of self reactive antibodies. Analysis of common strains of …
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The novel roles of BCL6 and BATF3 in regulating human CD8⁺ T cell dysfunction
Reduced effector function and elevated inhibitory receptor expression are hallmarks of exhausted CD8⁺ T cells, yet the underlying molecular and epigenetic drivers remain incompletely defined. Here, we developed an in vitro repeated stimulation model to recapitulate features of human CD8⁺ T cell …
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The transcription factor Zfx is required for tumorigenesis caused by Hedgehog pathway activation
… in the skin following deletion of the inhibitory receptor Ptch1. Co-deletion of Zfx also delayed development of Hh-dependent MB caused by Ptch1 deletion in vivo. In contrast, Zfx was dispensable for the development of the PTEN-dependent brain tumor glioblastoma, showing that a …
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Transcriptional Regulation of Clr-b (Clec2d) in Health and Disease
… is facilitated by germline-encoded NK cell receptors, including the NKR-P1B inhibitory receptor. The NKR-P1B-ligand, Clr-b, is broadly expressed by normal healthy cells, yet rapidly downregulated during pathological alterations, resulting in NK cell disinhibition via NKR-P1B. This thesis …
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Memory Potential, Molecular Characterization, and Translational Applications of The Novel Theo/Tceo T Cell Phenotype
… suppression, in part by targeting T cell co-receptors on the cell surface with either agonist or antagonist antibodies. Targeting the T cell co-stimulatory receptor 4-1BB with agonist antibodies engenders strong antitumor responses in multiple murine tumor models, in part by expanding the …
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Novel Imaging-Based Techniques Reveal A Role For Pd-1/Pd-L1 In Tumor Immune Surveillance In The Lung
<p>The binding of immune inhibitory receptor Programmed Death 1 (PD-1) on T cells to its ligand PD-L1 has been implicated as a major contributor to tumor induced immune suppression. Clinical trials of PD-L1 blockade have proven effective in unleashing therapeutic anti-tumor immune responses in a …
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Engineering aglycosylated antibody variants with immune effector functions
… Fc regions of the antibody with the Fc gamma receptors (Fc[gamma]Rs) on immune cells - is critical to the efficacy of several. This thesis describes the engineering of antibody Fc domain interactions with Fc[gamma]Rs, using the' yeast S. cerevisiae. In an initial step, a microbial system for …
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Genetic Investigation of MHC-independent Missing-self Recognition by NK Cells
… and more specifically, the NKR-P1B:Clr-b receptor-ligand system and its role in bone marrow transplantation. In the first results chapter, we generated hybridoma clones producing monoclonal antibodies against another inhibitory receptor in the Nkrp1 receptor family, NKR-P1G via the CELLISA …
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IGE PRODUCTION REGULATION VIA CD23 STALK ENGAGEMENT AND CELL CYCLE STIMULATION
CD23, the low affinity receptor for IgE, is expressed mainly on B cells and has been shown to regulate IgE production. Previously, recombinant mouse and human CD23 were constructed with a trimerizing isoleucine zipper motif attached in frame to the N-terminus of the entire extracellular CD23 …
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Bhlhe40: Required For Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy
… such as anti-CTLA-4 or anti-PD-1 that block the receptors from binding with their ligands, thus allowing for CD4<sup>+</sup> and CD8<sup>+</sup> T cell priming and activation(Wei et al., 2017). However, the required epigenetic and transcriptional features that T cells must possess to …
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Targeting Pd-1/Pdl-1 Signaling In The Treatment of Osteosarcoma Lung Metastasis
… mechanisms such as binding of immune inhibitory receptor, PD-1 with PDL-1, which is upregulated in cancer cells, may cause disease relapse.</p> <p>The effect of PD-1 blockade on NK cells and macrophages has not been investigated till date. The aim of this study was to determine if PD-1 …
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Programmed death-1 regulates islet-specific lymphocytes in type 1 diabetes
Programmed death-1 (PD-1) is a T cell inhibitory receptor important for tolerance maintenance. PD-1 is highly expressed on chronically stimulated T cells, such as those specific for persistent viral or tumor antigens. PD-1 pathway blockade revolutionized cancer therapy in recent years. While …
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Using Hi-Spots to investigate in vitro network dysfunction in Cysteine String Protein ? knockout mice
… the emergence of a co-ordinated excitatory and inhibitory network, demonstrating a maturing pattern of activity involving single spikes developing into bursting behaviour driven by intrinsic synaptic activity. This activity can be represented as frequency or averaged amplitude (RMS), increases …
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Investigating the antibody-independent functions of B lymphocytes
… monocytes. The absence of Siglec-G, an inhibitory receptor expressed in innate B1a cells, exacerbates AKI in murine models. Conversely, concomitant administration of a Siglec-G agonist, sialic acid (Neu5AC), ameliorated AKI and reduced renal neutrophil infiltration. These data suggest …
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Maintenance and function of antigen-specific CD4 T cells within the lung during tuberculosis
… of these Mtb-specific CD4 T cells expressing the inhibitory receptor PD-1 exhibits hallmarks of memory T cells and their maintenance requires intrinsic expression of ICOS, the transcription factor Bcl6, and the chemokine receptor CXCR5. Furthermore we find that a majority of KLRG1+ IFN-γ producing …
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Role of Siglec-7 in ganglioside recognition and modulating NK cell biology
… cancers. Siglec-7 is classified as<br/> an inhibitory receptor as it contains immunoreceptor tyrosine based inhibitory<br/> motifs. It has been shown to inhibit NK cytotoxicity in cellular assays thereby<br/> implying a role for it in NK cell mediated tumour surveillance.<br/> The aim of …
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Identification and Knockout of Immunodominant Endogenous Retroviral Antigen in Murine Tumor Models
… surface display to develop antibodies against an inhibitory receptor CD161, which was overexpressed in clonal CD8+ T cells found in primary human glioma samples. Inactivation of KLRB1, the gene encoding for CD161, in T cells was previously found to result in higher activation and improved T-cell …
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