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Showing 1 to 3 of 3 for “"Inhibitors of tubulin polymerization."”.
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Design and synthesis of indole-based analogues of OXi8006 as inhibitors of tubulin polymerization and their incorporation as payloads in drug-linker constructs.
… Baylor University, exhibited potent inhibition of tubulin polymerization and strong cytotoxicity against human various cancer cell lines. In previous studies, OXi8007, the phosphate prodrug of OXi8006, demonstrated vascular disrupting activity within 2 hours of administration by targeting tumor …
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Synthesis and biological evaluation of structurally diverse indole-based analogues as inhibitors of tubulin polymerization and synthesis of drug-linker constructs cleavable by enzymes present in the tumor microenvironment.
A sub-set of inhibitors of tubulin polymerization that bind to the colchicine site demonstrate dual functionality as both potent cytotoxins (antiproliferative agents) and effective vascular disrupting agents (VDAs). Our previous studies led to the discovery of a potent inhibitor of tubulin …
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Design and synthesis of benzosuberene and tetracyclic-based molecules inspired by natural products as inhibitors of tubulin polymerization and preparation of drug-linker constructs to facilitate tumor selective targeted delivery.
One primary research interest of the Pinney Research Group centers on the design and synthesis (and biological evaluation through long-standing collaborations) of small-molecule inhibitors of tubulin polymerization and development of targeting strategies that facilitate selective delivery of …