Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 3419 for “"Inhibitors"”.
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Discovery of Inhibitors of Inhibitors of Apoptosis Proteins and Novel Tubulin Polymerization Inhibitors as Potential Anticancer Agents
… our discovery of a series of novel survivin inhibitors based on the hydroxyquinoline scaffold from our previously reported lead compound, MX-106. MX-106 selectively downregulated survivin protein levels and induced apoptosis in melanoma A375 and prostate PC3 cancer cells. A new series of …
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Baculovirus inhibitors of apoptosis
A putative inhibitor of apoptosis gene was located in the Heliothis zea nucleopolyhedrovirus (HzSNPV) genome, at map units 76 to 77. Alignment of the predicted amino sequence encoded by this gene with reported inhibitor of apoptosis (iap) sequences identifted a RING finger and baculovirus IAP …
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Development of Rational Combination Therapy With Parp Inhibitors and Kinase Inhibitors In Tnbc
<p>Poly (ADP-ribose) polymerase inhibitors (PARPi) emerge as potential targeting drugs for BRCA-deficient cancers including triple negative breast cancer (TNBC). However, it has been reported that a subgroup of patients even with BRCA mutation fails to respond to PARPi in multiple clinical trials. …
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Discovery of Novel Tubulin Polymerization Inhibitors and Survivin Inhibitors as Potential Anticancer Agents
… of a series of novel tubulin polymerization inhibitors. Our lab previously reported a set of 2-aryl-4-benzoyl- imidazoles (ABI) derivatives with potent anti-proliferative activity against melanoma cells and xenografts. A new series of 4-aryl-2-benzoyl-imidazoles were designed and synthesized …
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Designing Allosteric Inhibitors of Thrombin
… potent, small, aromatic molecules as allosteric inhibitors of thrombin. Of the 28 potential inhibitors, 11 molecules inhibited thrombin with reasonable potency. Structure activity relationship studies showed that sulfation at the 5-position of the benzofuran scaffold was essential for targeting …
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Potential Natural Product Phosphodiesterase Inhibitors
… the role of phosphodiesterase (PDE) enzyme inhibitors in sexual dysfunction and mood regulation. First, naturalproducts were screened by computer modeling of PDE5A1. Second, compounds were isolated from a plant traditionally used as an aphrodisiac. Third, a new synthesis of psychoactive PDE4 …
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Surfactant properties of corrosion inhibitors
… the popularity of surfactants as corrosion inhibitors, their actual behaviour inside a pipeline is not well understood. The homologous alkylbenzyldimethylammonium chlorides CnBDMAC series is one of the most common corrosion inhibitors used in the oil industry. This thesis addresses some of …
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Sephadex G-25 and Charcoal Separation of Mouse Growth Inhibitors in Soybeans from Trypsin Inhibitors
<p>Rising costs have changes man’s ideals and eating habits. Plant ingredients, because of their relatively low costs, have been increasingly used as a substitute for animal proteins. If these plant ingredients could be directly utilized by man, this would be a more efficient use of energy and …
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Met inhibitors στον μη μικροκυτταρικό καρκίνο του πνεύμονα / Met inhibitors in non–small cell lung cancer
… Τα ευρήματα υποστηρίζουν τη χρήση των MET inhibitors ως αποτελεσματικών και κλινικά ανεκτών θεραπευτικών επιλογών πρώτης γραμμής για ασθενείς με MET exon 14 skipping NSCLC, σε συμφωνία με τις κατευθυντήριες οδηγίες NCCN και ESMO. Παρά την αναπόφευκτη εμφάνιση επίκτητης αντίστασης, νέες …
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Characterizing resistance of Erysiphe necator to fungicides belonging to the quinone outside inhibitors and demethylation inhibitors
… of Erysiphe necator to quinone outside inhibitors (QoIs) is now widespread, and resistance to demethylation inhibitors (DMIs) has also developed. The goal of this research was to characterize fungicide resistance by elucidating resistance mechanisms and determining its stability. QoI …
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Lariat peptide inhibitors of Abl kinase
A majority of kinase inhibitors predominantly occupy the highly conserved adenine-binding pocket located in the kinase catalytic cleft, and therefore the target selectivity of these molecules is a major concern. In order to design highly specific next-generation drugs, it is essential to exploit …
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Small Molecule Inhibitors of HPV16 E6
<p>High-risk human papillomaviruses (HR-HPVs) cause nearly all cases of cervical cancer. HPV 16 E6, one of two viral oncogenes, protects cells from apoptosis by binding to and accelerating the degradation of several apoptotic proteins, including caspase 8 and p53. We proposed that blocking the …
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Thieves of thankfulness: inhibitors of gratitude
… 2010). This study investigated four possible inhibitors of trait gratitude: cynicism, materialism/envy, indebtedness, and narcissism. The study sample consisted of upper-level undergraduate psychology college students from a university in eastern Washington. These potential inhibitors were …
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Small molecule inhibitors of parasitic enzymes
… is threefold:-(i) development of potential novel inhibitors of cysteine proteases from the causative agents of Malaria, African sleeping sickness and Chagas disease, (ii) development of potential new and novel anti-trypanosomal inhibitors of trypanosome alternative oxidase, and (ii) synthetic and …
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PRMT5 Inhibitors in Merkel Cell Carcinoma
… arginine methyltransferase 5 (PRMT5). PRMT5 inhibitors are already being tested in a variety of other solid and liquid tumors to good effect. Our data suggest that PRMT5 inhibitors may be effective in treating a specific subtype of MCC defined by a viral driver and wildtype p53. Treatment …
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Effect of inhibitors on hydrocarbon oxidation
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1961.
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