Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Inhibitor of differentiation"”.
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The role of Id2 (inhibitor of differentiation, DNA binding) in dendritic cell development in steady state and inflammation
Dendritic cells are professional antigen presenting cells that capture antigens and migrate to lymphoid tissues where they elicit specific immune responses. Several DC subtypes have previously been characterised, depending on their function and location. Each subtype appears to have a specialised …
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Regulation of RNA polymerase III transcription by the ID1, ID2, ID3 and E47 proteins
… (pol III) is responsible for transcribing a set of genes that are involved in protein synthesis, including transfer (tRNA) and 5S ribosomal RNA (5S rRNA). Pol III transcription levels are increased in many cancers, as increased protein synthesis is required for tumour growth. Furthermore, it has …
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TGF-beta,Smad signaling in hepatic stellate cells and during liver fibrogenesis
… growth factor (TGF)-beta is a key mediator of hepatic stellate cell (HSC) activation and extracellular matrix accumulation leading to fibrosis. Aim of the present study was to perturb the TGF-beta pathway in this process by overexpression of Smad7, an intracellular antagonist of TGF-beta …
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The role of Inhibitors of Differentiation proteins ID1 and ID3 in breast cancer metastasis
Breast cancer is a leading cause of cancer death in women. While locally-confined breast cancer is generally curable, the survival of patients with metastatic breast cancer is very poor. Treatment for metastatic breast cancer is palliative not curative due to the lack of targeted therapies. …
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The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer
Breast cancer is the second leading cause of death in women globally. This is in part due to poor therapy response, cancer cell drug resistance and the debilitating side effects associated with most therapies. There is therefore a need to improve current breast cancer therapy and/or to develop new …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… excessive proliferation and apoptosis resistance of pulmonary arterial smooth muscle (PASMCs) and endothelial cells (ECs) has been attributed to the pathogenesis of pulmonary arterial hypertension (PAH). It is an incurable cardiovascular disorder, which leads to right heart failure and death, if …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… excessive proliferation and apoptosis resistance of pulmonary arterial smooth muscle (PASMCs) and endothelial cells (ECs) has been attributed to the pathogenesis of pulmonary arterial hypertension (PAH). It is an incurable cardiovascular disorder, which leads to right heart failure and death, if …