Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 3772 for “"Inhibitor"”.
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INHIBITOR RESISTANCE MECHANISMS AND INHIBITOR DESIGN IN ¿¿-LACTAMASES
… design of new and highly effective ¿¿-lactamase inhibitors. This in turn will prolong the efficacy of existing ¿¿-lactams. Likewise, because ¿¿-lactamase inhibitors have high structural similarity to ¿¿-lactams, information gleaned from the study of the former will inform on the design of the …
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Calpain inhibitor design inspired by the natural inhibitor calpastatin
… great interest and medical relevance to design inhibitors that can specifically target calpain without interfering with the other numerous cellular cysteine proteases. The cytosolic and ubiquitous calpains-1 and -2 have a naturally occurring and specific inhibitor, calpastatin, which binds with …
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Bax-Inhibitor-1-vermittelte Neuroprotektion
BI-1 (Bax-Inhibitor-1) konnte in Hefen, Pflanzen und verschiedenen Säugetierzellen vorwiegend als anti-apoptotisches Protein charakterisiert werden.Um die Funktion von BI-1 in Neuronen zu untersuchen, wurde sowohl HA- als auch GFP-getaggtes BI-1 transient und stabil in CSM14.1- (nigro-striatale …
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SCRIBBLE: A POTENTIAL DUAL KINASE INHIBITOR
Extracellular signal-regulated kinases (ERKs) modulate cellular activities in response to extracellular stimuli and play important biological roles. Thus, perturbed kinase pathways induce pathological conditions, such as tumor development. Rit, a novel member of the Ras family GTPases, activase …
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Corrosion Inhibitor for Potash Solution Mining
… cost, this work proposed to apply a corrosion inhibitor that is compatible to potash brine environments, less toxic than the base substrate potash, commercially available, and provides sufficiently high corrosion inhibition performance. To identify such inhibitor, three sets of chemicals …
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Variation in Kunitz Soybean Trypsin Inhibitor Properties
Made available in DSpace on 2014-12-12T00:51:23Z (GMT). No. of bitstreams: 1 7121093.pdf: 2498589 bytes, checksum: 3c446ff5ca63467b060ac33a06a1f21b (MD5) Previous issue date: 1971
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Inhibitor studies on para-aminobenzoic acid synthase.
… assay system used and the organic synthesis of inhibitors of ADC synthase. The purification and characterisation was carried out of newly cloned 6-His tagged PABA synthase enzymes from E. coli. engineered to overexpress these proteins. The assay system used was refined and substrate kinetic data …
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Hv1 novel peptide inhibitor extracted from tarantula venom
This thesis investigates the interaction between GsAF-I, a peptide from the venom of the tarantula Grammostola rosea, and human voltage-gated proton (Hv1) channels, critical in pH regulation and cellular signaling. Utilizing patch clamp techniques on genetically modified Chinese Hamster Ovary cells …
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Serotonin Reuptake Inhibitor Use During Pregnancy: Perinatal Outcomes
… syndrome (NBS) in infants of serotonin reuptake inhibitor (SRI)-treated pregnancies, compared with infants of women with psychiatric illness not treated with medication. METHODS: Retrospective cohort study of pregnancies followed in a prenatal clinic for women with psychiatric illness. Infants of …
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Existence of Inhibitor of Apoptosis in Tumor Exosomes
… of the characteristics of cancer, of which the inhibitor of apoptosis (IAP) family of proteins plays an important role. It has also been shown that cancer cells secrete vesicles called tumor exosomes (TEX) which are loaded with bioactive molecules which strongly influences the tumor …
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Molecular characterization of the Drosophila mitotic inhibitor Frühstart
… bereits gezeigt werden, daß Frs als mitotischer Inhibitor wirkt, der spezifisch der Funktion der Protein-Phosphatase String entgegenwirkt, dadurch die Mitosen in den Zellen der Ventralfurche verzögert und so diesen Zellen erlaubt, die für die Ventralfurchenbildung erforderlichen morphogenetischen …
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Folding Studies on Mutants of Chymotrypsin Inhibitor 2
… N-terminus and hydrophobic core of Chymotrypsin Inhibitor 2 (CI2) have been studied. All mutants adhere to a two-state model for protein folding , and are destabilised relative to wild-type. Mutation of N-cap residue S31 to Ala or Gly destabilises CI2 by nearly 1 kcal mol-1, with respect to both …
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Funktionelle Charakterisierung des Komplexes aus Ornithin-Decarboxylase, Antizym und Antizym-Inhibitor sowie Identifikation einer Antizym-Inhibitor-Spleißvariante durch Bindung an FK506
… C-terminal verkürzte Spleißvariante von Antizym- Inhibitor als neuer Interaktor für FK506 identifiziert. Die Interaktion war FK506-spezifisch, da keine Interaktion mit anderen an Dexamethason gekoppelten Liganden nachzuweisen war. Die im 3-Hybrid-Screen isolierte Spleißvariante wurde zusätzlich …
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In search of: a membrane sialoglycoprotein cell growth inhibitor
Call number: LD2668 .T4 BIOL 1989 G55
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In search of human cytochrome P450 1A1 enzyme inhibitor
… benefits. Until now, no potent CYP1A1-specific inhibitor has been identified. Compounds that inhibit CYP1A1 can potentially act as chemo-preventive agents in the treatment of cancer. In this thesis, at first, a yeast strain that co-expresses CYP1A1 with a genetically engineered variant of human …
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Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor
… binding of MS-275, a novel histone deacetylase inhibitor, in patients with solid tumors and lymphomas. A validated LC/MS assay was developed to quantitate MS-275 in plasma, human liver microsomes and urine. The pharmacokinetic (PK) evaluation was done using a non-compartmental approach. In-vitro …
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Biochemical Context Drives Inhibitor Selectivity in Aurora A Kinase
… of human cancers that have driven a wealth of inhibitor development targeting Aurora activity, but no compounds have been FDA approved. Recently, Aurora A was shown to provide a non-catalytic stabilizing scaffold for N-Myc, the protein product of the MYCN gene, which is heavily amplified in …
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An improved synthesis of the HDAC inhibitor trichostatin A
<p>Histone deacetylase inhibitors (HDIs) have found a wide variety of medicinal uses and are most noted for their specific apoptotic action towards cancer cells. Several hydroxamate HDIs have since been moved on to phase 1 and 2 clinical drug trials, with one having already been approved for …
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