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Showing 1 to 1 of 1 for “"Inhibition of tubulin polyermization."”.
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Design and synthesis of indole-based analogues of OXi8006 as inhibitors of tubulin polymerization and their incorporation as payloads in drug-linker constructs.
… Group at Baylor University, exhibited potent inhibition of tubulin polymerization and strong cytotoxicity against human various cancer cell lines. In previous studies, OXi8007, the phosphate prodrug of OXi8006, demonstrated vascular disrupting activity within 2 hours of administration by …