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Showing 1 to 1 of 1 for “"Inherited Cancer Syndromes"”.
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Omics Approaches to Uncover Germline and Somatic Variation Underlying Inherited Sarcomagenesis
… underlying sarcomagenesis, we leveraged two rare inherited cancer predisposition syndromes, Li-Fraumeni Syndrome (LFS), and LFS-like (LFSL), both with a high incidence of sarcomas. LFS is caused by mutations in the tumor suppressor gene <em>TP53 (p53)</em><em>, </em>but has variable and incomplete …