Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Inhaler"”.
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Design and development of an automated metered dose inhaler (MDI) for asthmatic patient
… a doctor using a spacer device with metered dose inhaler (MDI) to allow the infant to breathe in the medication known as salbutamol. Current asthma spacer does not provide systematic way of monitoring and displaying the percentage value of the propellant. Furthermore, user non-compliance is found …
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A STUDY ON PARTICLE SURFACE ROUGHNESS AND ITS IMPACT ON TABLET AND INHALER TECHNOLOGY
… roughness of carrier particles for dry powder inhalers was also examined. Rougher carrier particles increased the fine particle fraction of the inhaler formulation. A new method of fine particle fraction collection was developed for the use in dissolution and permeability testing of …
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The relationship between clinical trial participation and inhaler technique errors in asthma and COPD patients
Background Incorrect inhaler use is associated with poorer health outcomes, reduced quality of life, and higher healthcare utilisation in patients with asthma and COPD. Method We performed an observational study of pressurized metered-dose inhaler technique in patients with asthma or COPD. Patients …
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Development of dry powder Inhaler and nebulised nanoparticles formulations of chrysin for the potential treatment of asthma. Development of dry powder inhaler of chrysin and nebulised nanoemulsion combination of chrysin and budesonide; Evaluating the anti-inflammatory activity of the combination formulation of chrysin and budesonide for asthma
… of chrysin and budesonide. Dry powder inhaler formulations were used first, where chrysin was processed using three different techniques, namely ball-milling, sonocrystallisation, and spray drying, to obtain a suitable particle size for inhalation. The highest fine particle fraction was …
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Development of a Dry Powder Inhaler and Nebulised Nanoparticle-Based Formulations of Curcuminoids for the Potential Treatment of Lung Cancer. Development of Drug Delivery Formulations of Curcuminoids to the Lungs using Air Jet Milling and Sonocrystallisation Techniques for Dry Powder Inhaler Preparations; and Nanoemulsion and Microsuspension for Nebuliser Formulations
Curcuminoids have strong anticancer activities but have low bioavailability. The highest rate of cancer deaths comes from lung tumours; therefore, inhaled curcuminoids could treat lung cancer locally. To date, there are no nebulised formulations of curcuminoids, and there are no inhalable …
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Analysis of the Repeated Measurement Data using the Hierarchical Clustering and Nonlinear Regression Methods in Asthma Pharmacogenetic Study
… patients were enrolled. With using combination inhaler (budesonide/formoterol 320μg/d) for 80 days, we monitored morning and evening peak expiratory flow daily and pulmonary function every 8 weeks. Twelve SNPs from 9 candidate genes including ADCY9 132007 T>C (Ile772Met), ALOX5 -1708 G>A, …
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Evaluation of novel tool to ensure asthma and COPD patients use the approved inhalation technique when they use an inhaler. Clinical pharmacy studies investigating the impact of novel inhalation technique training devices and spacers on the inspiratory characteristics, disease control and quality of life of patients when using their inhalers.
Many respiratory patients misuse their inhaler. Although training improves their inhaler technique, patients do forget the correct inhaler use with time. In the current work, three clinical studies investigated novel tools designed with feedback mechanisms to ensure patients use the correct …
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Investigation to Identify the Influence of Mannitol as a Carrier on the Ex-Vivo Dose Emission and the In-Vitro Aerodynamic Dose Emission Characteristics of Dry Powder Inhalers of Budesonide
… using the Easyhaler® multi-dose high resistance inhaler with reservoir was compared with the RS01® single dose capsule low resistance inhaler at two different inhalation rates. Aerodynamic characteristics, flow and surface energies were investigated together with in vitro and ex vivo assessment …
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In vitro methods to predict aerosol drug deposition in normal adults
… in vivo drug deposition from dry powder inhalers, DPIs, in lung-normal human adults. Three physical models of the mouth, throat and upper airways, MT-TB, were designed and validated using the anatomical literature. Small, medium and large versions were constructed to cover approximately …
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A cross-sectional survey on the effects of temperature and humidity on health outcomes in individuals with Chronic Obstructive Pulmonary Disease: a pilot study
… activity, higher exacerbations, increased rescue inhaler use and hospitalizations. Future prospective research should consider confounders, disease severity, individual geographical regions, and spectrums of temperature and humidity. Understanding the effects of temperature on COPD outcomes will …
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Novel Technology for Crystal Engineering of Pharmaceutical Solids
… pulmonary drug delivery system via dry powder inhaler (Foradil inhaler). The results demonstrate that the THF particles generated using MASCW process displayed greater aerodynamic performance compared to conventional spray-dried THF sample. In the final chapter, synthesis of inorganic …
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Application of data-driven technologies for asthma self-management
… peak flow measurements. Keeping track of relief inhaler usage can also help measure asthma control. However, patients may regard this level of monitoring as tedious because it involves high levels of active engagement on their part. Machine learning and mobile health (mHealth) have the potential …
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Investigation to Identify the Influence of the Surface Energetics of the Dry Powder Formulations of Budesonide and Theophylline on Their Aerodynamic Dose Emission Characteristics.
… play a key role in the delivery of a dry powder inhaler formulation into the lungs, as there must be a sufficient balance of adhesive and cohesive forces to allow optimal lung delivery. In this study, measuring the surface energies of a set of single drug and carrier (budesonide or theophylline …
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Comparison of Two Aerosolized Bronchodilators in the Treatment of Severe Equine Chronic Obstructive Pulmonary Disease
… placebo via an equine Aeromask and metered dose inhaler. Physiologic shunt fraction (QS/QT), alveolar dead space fraction (VD/VT) and alveolar to arterial oxygen tension difference (p(A-a)O₂) were calculated using standard formulas. At time zero, horses demonstrated severe respiratory compromise …
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Investigations to identify the influence of the inhalation manoeuvre on the ex-vivo dose emission and the in-vitro aerodynamic dose emission characteristics of dry powder inhalers: Studies to identify the influence of inhalation flow, inhalation volume and the number of inhalations per dose on the ex-vivo dose emission and the in-vitro aerodynamic dose emission characteristics of dry powder inhalers.
Currently available dry powder inhalers (DPIs) for drug delivery to the lungs require turbulent energy to generate and disperse aerosol particles in the respirable range ¿5¿m during inhalation. The patient's inspiratory effort together with the resistance inside the device creates this energy. …
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The Effectiveness of Pharmacist Interventions in Improving Asthma Control and Quality of Life in Patients with Difficult Asthma
… 58.8%, 46.9% and 17.6% of patients had optimal inhaler technique using Accuhalers, Turbohalers or pMDIs; education improved technique but this was not maintained at six-months. Adherence rates <80% were observed in 57.5% of patients at baseline, and was improved in the PI group at six-months …
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Media and Memory: The Impact of Presentation Style on Middle Aged and Older Adults' Recall of Health Information
… triggers of asthma symptoms and questions about inhaler usage. Participants in the print condition and half of the participants in the video condition then received print materials to take home, and approximately one week later all participants completed the knowledge assessments a second time. …
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Evaluation of clinical methods of pulmonary gas exchange assessment in the standing horse
… seven of the Group 2 horses from a metered-dose inhaler through an equine facemask at a dose of 90 μg per 100 kg. Blood samples and tidal gas samples were obtained 15 minutes post-treatment, and Q<sub>S</sub>/Q<sub>T</sub> and (V<sub>DB</sub>/V<sub>T</sub>) were calculated. Albuterol caused …
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Development of an inhaled liposomal-loaded azithromycin formulation for the treatment of chronic respiratory infection
… that could be delivered via dry powder inhaler for use in chronic lung infection. By delivering the antibiotic directly to the site of action in the lungs, higher local concentrations could be achieved whilst overcoming issues with oral therapy such as systemic side effects and the …
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Stable submicron protein particles : formation, properties, and pulmonary applications
… (HFA) for pressurized metered dose inhaler (pMDI) delivery. The flocculated rods are templated by atomized HFA droplets that evaporate and shrink to form particles with optimal aerodynamic diameters for deep lung delivery. Fine particle fractions of 38-48% were achieved. This novel …
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