Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Inhaled corticosteroid"”.
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Personalising Inhaled Corticosteroid Dose Response in Persistent Asthma
This thesis examines the overarching theme of inhaled corticosteroid (ICS) dose response effects on a variety of asthma outcome measures; with further importance placed on the application of these findings to personalising ICS dosing for the individual asthmatic.<br/><br/>The introduction provides …
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Do Statins Improve Outcomes in Patients With Asthma on Inhaled Corticosteroid Therapy? A Retrospective Analysis of the Mississippi Medicaid Database 2002-2004.
… days prior to which the subject had at least 1 inhaled corticosteroid (ICS) prescription and at least an 80% adherence rate to statins. Medicaid beneficiaries identified as asthmatics and on ICS therapy, but not on statins were selected as the unexposed population. Each subject in the exposed …
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The Effect of Phosphodiesterase Inhibitors on the Induction of Gene Expression by Long-Acting beta2-Adrenoceptor Agonists and Glucocorticoids
… already taking long-acting β2-agonists (LABA)/inhaled corticosteroid (ICS) combination therapy. However, this benefit is seen only in patients of the severe, bronchitic, frequent exacerbator phenotype. Several strategies have been proposed to enhance the clinical efficacy of PDE4 inhibitors. …
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Analysis of treatment of respiratory disease in the United Kingdom and United States
… guideline recommendations, and appraisal of inhaled corticosteroid (ICS) prescribing. RESULTS: National medicine utilisation figures indicated an increasing preference over time for combination therapy with ICS and long-acting beta agonist (LABA) inhalers. Therapy for asthma demonstrated some …
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Immunopathological and Structural Alterations in Difficult to Control Asthma
… with bronchodilators and low to moderate dose inhaled corticosteroids. However, an estimated 5-10% of the population presents a more troublesome disease, often referred to as severe asthma. The aim of present thesis was to study the relationship between histopathological alterations and …
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A Proof-of-Concept Study to evaluate the benefit from add-on therapy with montelukast versus salmeterol in children with asthma carrying the Arg/Arg-16 β2-receptor genotype
… randomised controlled trial of add-on therapy to inhaled steroids, with either oral montelukast or inhaled salmeterol, on children carrying the susceptible Arg-16 genotype over a 1-year period.MethodsI have explored methodological issues of importance in the design of this complex study in …
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Non-invasive method of measuring airway inflammation : exhaled nitric oxide
… bronchodilator therapy only, or on regular inhaled corticosteroids. 6. To compare the levels of NO in a pilot group of asthmatic children before and after commencement of inhaled corticosteroids. Methods A Dasibi Environmental Corporation Model 2107 chemiluminescence analyser was adapted …
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Reduced corticosteroid sensitivity in smokers with asthma: potential mechanisms and treatment
… with asthma display reduced responses to both inhaled and oral corticosteroids with associated increased symptoms, accelerated decline in lung function and increased use of health care services. Little work has been undertaken to address the possible causes of this reduced response and to find …
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Analysis of the Repeated Measurement Data using the Hierarchical Clustering and Nonlinear Regression Methods in Asthma Pharmacogenetic Study
… (LABA) is the most powerful bronchodilator and inhaled corticosteroid (ICS) was the most effective anti-inflammatory drug currently available in asthma management. The combination treatment including LABA and ICS has been considered as an essential drug to achieve optimal asthma control. …
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The Role of Hydrocortisone on the Development and Maintenance of Ion Transport Pathways Essential to Mucociliary Clearance in Differentiated Normal Human Bronchial Epithelial Cells
… against potential injury and infection caused by inhaled particles, debris and microbial pathogens. In order to maintain the health of the lungs and surrounding tissues, the epithelium utilizes numerous defense mechanisms that complement the barrier function of the epithelium. These include the …
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Effect of Cigarette Smoke Exposure on Bronchial Hyperresponsiveness in Mice and Response to a Corticosteroid and/or a β2-Adrenergic Agonist and Effect of Cigarette Smoke Extract on Cytokines Release from U937 Cells.
… 126,000 US deaths were attributed to COPD. |Corticosteroids and/or β2 adrenergic agents are the main line of therapy for both asthma and COPD. However, some people with asthma, and the majority with COPD show diminished response to corticosteroid therapy. Various factors such as an increase …
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Effect of atorvastatin on asthma control and airway inflammation: a randomised controlled trial
… study. However, as all patients were receiving inhaled corticosteroid as part of their asthma therapy, it is possible that this may have masked any modest anti-inflammatory effects of the statin. Baseline asthma inflammation may also have been too low to show any significant improvement. Despite …
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The management of children's asthma in primary care : Are there ethnic differences in care?
… in completion rates. The overall use of inhaled corticosteroid medications had increased since previous New Zealand research was published. Multivariable modelling that adjusted for potential confounders did not identify ethnic differences in the use of inhaled corticosteroids or oral …